Results 131 to 140 of about 6,474 (167)
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Endocrinology, 1977
The effect of estradiol and thyroid hormone treatment on pituitary TRH binding and TSH and PRL responses to the neurohormone was studied. A significant increase in the number of pituitary TRH binding sites was observed between 2 and 4 days after daily administration of estradiol benzoate with a plateau at 300% of control being reached at 7 days. Plasma
A D, Léan +4 more
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The effect of estradiol and thyroid hormone treatment on pituitary TRH binding and TSH and PRL responses to the neurohormone was studied. A significant increase in the number of pituitary TRH binding sites was observed between 2 and 4 days after daily administration of estradiol benzoate with a plateau at 300% of control being reached at 7 days. Plasma
A D, Léan +4 more
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Endocrinology, 1987
The present study was undertaken to test the effects of TRH on thyroid hormone receptors and responses in GH4C1 rat pituitary tumor cells. TRH caused a loss of up to 32% of specific nuclear thyroid hormone binding sites with an ED50 of approximately 1 nM, and this loss was additive to the receptor down-regulation caused by T3 itself. Scatchard analysis
H, Kaji, P M, Hinkle
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The present study was undertaken to test the effects of TRH on thyroid hormone receptors and responses in GH4C1 rat pituitary tumor cells. TRH caused a loss of up to 32% of specific nuclear thyroid hormone binding sites with an ED50 of approximately 1 nM, and this loss was additive to the receptor down-regulation caused by T3 itself. Scatchard analysis
H, Kaji, P M, Hinkle
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Nihon rinsho. Japanese journal of clinical medicine, 1994
1) We successfully cloned a human thyrotropin-releasing hormone receptor (TRH-R) gene. The human TRH-R consists of 398 amino acids and is a member of the G protein-coupled receptor family. The gene has a single intron in the coding sequence. Although highly homologous to the rat and mouse TRH-Rs, the human TRH-R has several differences in the carboxyl ...
M, Yamada, M, Mori
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1) We successfully cloned a human thyrotropin-releasing hormone receptor (TRH-R) gene. The human TRH-R consists of 398 amino acids and is a member of the G protein-coupled receptor family. The gene has a single intron in the coding sequence. Although highly homologous to the rat and mouse TRH-Rs, the human TRH-R has several differences in the carboxyl ...
M, Yamada, M, Mori
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Solubilization and characterization of pituitary thyrotropin-releasing hormone receptors.
Molecular Pharmacology, 1989Thyrotropin-releasing hormone (TRH) receptors were solubilized from a rat pituitary tumor cell line, GH4C1, with digitonin. Convenient assays were developed based on the ability of hydroxylapatite and polyethyleneimine-soaked glass fiber filters to adsorb the solubilized [3H]methyl-TRH-receptor complex but not free [3H]methyl-TRH.
W J, Phillips, P M, Hinkle
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Dopaminergic Receptors in Bovine Retina and Their Interaction with Thyrotropin‐Releasing Hormone
Journal of Neurochemistry, 1983Abstract: A superfusion technique was employed to study the release of [3H]dopamine from isolated bovine retina. Only K+‐stimulated release was observed from both light‐ and dark‐adapted retina; release by other stimuli was from dark‐adapted retina only. Light‐evoked release of [3H]dopamine from dark‐adapted retina was blocked by thyrotropin‐releasing
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Effect of Cell Type on the Subcellular Localization of the Thyrotropin-Releasing Hormone Receptor
Molecular Pharmacology, 1997The localization of an epitope-tagged receptor for thyrotropin-releasing hormone (TRH) expressed in different cell contexts was studied with immunofluorescence microscopy. In pituitary lactotrophs, which normally express TRH receptors, and in AtT20 pituitary corticotrophs, TRH receptor immunoreactivity was primarily confined to the plasma membrane.
R, Yu, P M, Hinkle
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Thyrotropin-Releasing Hormone Receptor: Cloning and Regulation of Its Expression
1993Publisher Summary This chapter provides an overview of thyrotropin-releasing hormone receptor, its cloning, and the regulation of its action. The number of receptors on the surface membrane of cells may be decreased by the action of the receptor ligand or by the action of other extracellular regulatory factors that interact with other cell receptors.
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Thyrotropin-releasing hormone receptors
Trends in Pharmacological Sciences, 2001openaire +1 more source
The structure and function of the thyrotropin-releasing hormone receptor
Current Opinion in Endocrinology and Diabetes, 1995Daniel R. Nussenzveig +1 more
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