Results 101 to 110 of about 10,411 (253)

Evaluating the Link Between Thyroid Function Test Results and Levothyroxine Dose in the Management of Hypothyroidism: Can We Improve Dosing Regimes?

Clinical Endocrinology, Volume 104, Issue 4, Page 372-385, April 2026.
ABSTRACT Introduction Over 10 million thyroid function tests (TFTs) are carried out in England each year, most requests coming from primary care. Our previous work showed that only 25% of results for patients being treated with Levothyroxine fell within the TSH/FT4 boundary circumscribing 75% of untreated individuals.
Adrian H. Heald, Lakdasa D. Premawardhana, Peter N. Taylor, Suhani Bahl, Onyebuchi E. Okosieme, Anthony A. Fryer, Antonio Bianco, Colin M. Dayan, Michael P. Stedman   +8 more
wiley   +1 more source

Delivering Effective Hepatitis C Virus Treatment in an Embedded Primary Care Setting Within a Tertiary Care Hospital in Karachi, Pakistan

Journal of Viral Hepatitis, Volume 33, Issue 4, April 2026.
ABSTRACT Hepatitis C virus (HCV) endemic regions require accessible treatment interventions. Effectiveness and costs of a pilot HCV treatment programme were evaluated at an embedded primary care service within a tertiary care centre at Indus Hospital and Health Network in Karachi, Pakistan.
Sabeen Shah, Nyashadzaishe Mafirakureva, Adam Trickey, Aliya Hasnain, Uzma Khan, Saira Khowaja, Hiba Ashraf, Naila Baig‐Ansari, Matthew Hickman, Peter Vickerman, Josephine G. Walker, Aaron G. Lim   +11 more
wiley   +1 more source

Lack of GPNMB Is Associated With Altered Lipid and Glucose Metabolism and Disrupted Diurnal Hepatic Glycogen Regulation

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
Loss of GPNMB function in mice fed a high‐fat/high‐fructose diet aggravated adiposity and dyslipidemia while preserving systemic glucose tolerance. This phenotype was associated with impaired hepatic AKT–FOXO1 signaling, increased NF‐κB activation, altered glycogen metabolism, and rhythmic disturbances in energy expenditure and clock gene expression ...
Eliz Maria de Oliveira Furtado, Lina Jegodzinski, Juliano Jefferson da Silva, Ana Flávia Tostes, Lucas dos Santos, Pietra Souza Barsanele, Beatriz Santana‐Lima, Luciana Chagas Caperuto, Mery Natali Silva Abreu, Darko Castven, Andrea Schenk, Danusa Soares Dias, Jens U. Marquardt, Maristela Oliveira Poletini, Leonardo Vinícius Monteiro de Assis, Maria Nathália Moraes   +15 more
wiley   +1 more source

Hyperleukocytosis and Access to Minimal Residual Disease Testing Impact Outcomes in Children With Newly Diagnosed Acute Myeloid Leukemia in Thailand

Pediatric Blood &Cancer, Volume 73, Issue 3, March 2026.
ABSTRACT Background The survival outcomes among children with acute myeloid leukemia (AML) in low‐ and middle‐income countries are still poor despite adopting modern treatment regimens from developed countries. The study aimed to identify additional potential determinant factors for relapse and death among children with AML in Thailand. Methods In all,
Piya Rujkijyanont, Supak Ukritchon, Angkana Winaichatsak, Pitchayanan Kuwatjanakul, Thirachit Chotsampancharoen, Piti Techavichit, Su‐on Chainansamit, Lalita Sathitsamitphong, Kittima Kanchanakamhaeng, Usanarat Anurathapan, Napat Laoaroon, Chonthida Wangkittikal, Chalinee Monsereenusorn, Watinee Sanpote, Nattaporntira Phalakornkul, Pariwan Sripattanatadasakul, Daranee Isaranimitkul, Pokpong Na Songkhla, Phakatip Sinlapamongkolkul, Jassada Buaboonnam, Samart Pakakasama   +20 more
wiley   +1 more source

Connexin 26 Functions as a Direct Transcriptional Regulator During the Cochlea Development

Advanced Science, Volume 13, Issue 14, 9 March 2026.
Connexin26 can not only form intercellular channels that mediate rapid communication on the cell membrane, but also enter the nucleus as a transcription factor to directly regulate the transcription of nuclear genes. In the developing cochlea, Cx26 can control the maturation of the molecular scissor ADAM10 by regulating the transcription of TspanC8 ...
Xiaozhou Liu, Le Xie, Yuan Jin, Sen Chen, Xinyu Shi, Yanjun Zong, Zhengdong Zhao, Wei‐Jia Kong, Yu Sun   +8 more
wiley   +1 more source

Neuropsychiatric symptoms in preclinical and clinically manifest dementia: clusters and their health determinants

Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.
Abstract INTRODUCTION Neuropsychiatric symptoms (NPSs) are common in dementia, but their patterns in preclinical stages remain unclear. This study identified NPS clusters and associated health factors in a geriatric clinical population. METHODS We analyzed 1234 participants from the Italian GERIatric COgnitive evaluation memory clinic cohort with ...
Anna Giulia Guazzarini, Evangelos Galaris, Virginia Boccardi, Francesca Mancinetti, Carmelinda Ruggiero, J‐Sebastian Muehlboeck, Patrizia Mecocci, Eric Westman, Anna Marseglia   +8 more
wiley   +1 more source

Hypothyroidism as Prognostic Factor in Cutaneous Melanoma: A 1553‐Patient Single‐Center Study

Cancer Medicine, Volume 15, Issue 3, March 2026.
ABSTRACT Background Cutaneous melanoma is a rising global health concern and identifying modifiable or associated risk factors remains essential for improving prognostic stratification. Hypothyroidism, affecting approximately 5.1% of the general population in Germany, has been associated with various malignancies. This study investigates the prevalence
Julie Klose, Filipa Almeida Oliveira, Charalampos Varnava, Philipp Wiebringhaus, Grit Sophie Herter‐Sprie, Hans‐Joachim Schulze, Tobias Hirsch, Sascha Wellenbrock, Maximilian Kueckelhaus   +8 more
wiley   +1 more source

Identification of a novel THRB mutation causing thyroid hormone resistance syndrome. [PDF]

Arch Endocrinol Metab
Yang J, Wang C, Quan L, Jiang S.
europepmc   +1 more source

The Differential Diagnosis of Coma in the ICU: Hyperacute Postoperative Guillain‐Barré Syndrome—A Case Report

Clinical Case Reports, Volume 14, Issue 3, March 2026.
ABSTRACT Guillain‐Barré syndrome (GBS) is a rare, immune‐mediated neurological disorder that can be challenging to diagnose in postoperative patients due to atypical manifestations and overlapping conditions. This case report highlights the diagnostic and therapeutic challenges of GBS following vascular surgery. We present the case of a 56‐year‐old man
Miron Tiganas, Abdulrahman Ismaiel, Dan Sebastian Dirzu, Iris Aszalos   +3 more
wiley   +1 more source

JAK4D, a first-in-class thyrotropin-releasing hormone analogue, reverses scopolamine-induced memory deficits. [PDF]

Brain Commun
McMackin R, Price S, Slator GR, Hardiman O, Kelly JA.   +4 more
europepmc   +1 more source