Results 91 to 100 of about 594,054 (285)

Genetic Etiologies of Dystonia with Anarthria/Aphonia

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Dystonia with anarthria and/or aphonia (DAnAp) represents a distinctive phenotype manifesting across lifespan. Frequently associated with genetic disorders, early recognition is critical for diagnosis and management. Objectives To provide practical recommendations for the clinical evaluation of patients with DAnAp, enhancing ...
Anika Ménétrey, Eriberto Rayco, Maziar Emamikhah Abarghouei, Susan H. Fox, Anthony E. Lang, George M. Ibrahim, Carolina Gorodetsky, Christos Ganos   +7 more
wiley   +1 more source

Plasma Lipid Remodeling across Preclinical Burden, Disease Onset, and Early Motor Severity in Huntington's Disease

Movement Disorders, EarlyView.
Abstract Background and Objectives Huntington's disease (HD) evolves silently for years before motor onset, yet the systemic metabolic alterations accompanying cumulative exposure to mutant huntingtin and disease progression remain poorly understood.
Mohamed Bendimerad, Dominique Bonneau, Clarisse Scherer‐Gagou, Adriana Prundean, Karim Chikh, Oriane Vitalis, Audrey Olivier, Odile Blanchet, Judith Nzoughet‐Kouassi, Christophe Verny, Pascal Reynier, Juan Manuel Chao de la Barca   +11 more
wiley   +1 more source

Tracking conformational transitions of the gonadotropin hormone receptors in a bilayer of (SDPC) poly-unsaturated lipids from all-atom molecular dynamics simulations.

PLoS Computational Biology
Glycoprotein hormone receptors [thyrotropin (TSHR), luteinizing hormone/chorionic gonadotropin (LHCGR), and follicle stimulating hormone (FSHR) receptors] are rhodopsin-like G protein-coupled receptors.
Eduardo Jardón-Valadez, Alfredo Ulloa-Aguirre   +1 more
doaj   +1 more source

Hepatic hemangioendothelioma associated with production of humoral thyrotropin-like factor

, 2001
We report on 7 patients referred for treatment of hepatic hemangioendothelioma with increased thyrotropin levels. The serum thyroxine level was decreased in 4 and increased in 2.
Metcalfe, R, Davenport, M, Mark Davenport, Mieli-Vergani, G, Howard, E R, Russell Metcalfe, Ayling, R M, Charles R. Buchanan, Buchanan, C R, Hadzic, N, Giorgina Mieli-Vergani, Ruth M. Ayling, Nedim Hadzic, Edward R. Howard   +13 more
core   +1 more source

Bibliometric Analysis of Research on Pituitary Adenomas: Recent Progress in Pathogenesis and Clinical Management

Medicine Advances, EarlyView.
A bibliometric analysis of 15,418 publications mapped global research on pituitary adenomas and identified 6 major research themes. Keyword trends highlighted the growing prominence of artificial intelligence‐related research. ABSTRACT Background Pituitary adenomas (PAs) comprise most of the tumors that originate from the sellar region.
Zhengyang Shen, Kan Deng, Lin Lu, Jifang Liu, Zhang Ye, Yi Zhang, Yong Yao   +6 more
wiley   +1 more source

Thyrotropin receptors in thyroid plasma membranes. Characteristics of thyrotropin binding and solubilization of thyrotropin receptor activity by tryptic digestion

Journal of Biological Chemistry, 1975
Biologically active bovine 125I-thyrotropin preparations have been prepared, characterized, and used to evaluate the optimal conditions for thyrotropin binding to bovine thyroid plasma membranes in vitro. Binding of 125I-TSH has a pH optimum around 6.0 and is sensitive to the choice and concentration of buffer. Binding is inhibited by salts, especially
R L, Tate, H I, Schwartz, J M, Holmes, L D, Kohn   +3 more
openaire   +2 more sources

Incretin‐Based Therapies: A Testable Hypothesis Linking Incretin Signaling, Mitochondrial Redox, and OXPHOS Efficiency

Obesity, EarlyView.
ABSTRACT Objective Incretin‐based obesity therapies (IBTs), especially GLP‐1 receptor agonists (GLP‐1 RAs), effectively treat obesity and improve comorbidities. However, their impact on energy metabolism is unclear. A recent case of acute generalized muscle weakness in a patient with mitochondrial myopathy after tirzepatide exposure raises concerns ...
Bryn Falahee, Caroline M. Apovian, Nawfal Istfan   +2 more
wiley   +1 more source

TRH-induced secretion of adrenocorticotropin and cortisol in dogs with pituitary-dependent hypercortisolism

Veterinary Quarterly, 2018
Background: In dogs, spontaneous Cushing’s syndrome is most often pituitary-dependent and caused by hypersecretion of adrenocorticotropic hormone (ACTH), resulting in increased adrenocortical glucocorticoid secretion similar to horses.
Tera Pijnacker, Marieke Knies, Sara Galac, Karin Sanders, Jan A Mol, Hans S Kooistra   +5 more
doaj   +1 more source

From Isolated to Complex: Diagnostic Yield of Chromosomal Microarray and Exome Sequencing in Fetal Growth Restriction

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective To characterize the overall diagnostic yield of sequential chromosomal microarray (CMA) and exome sequencing (ES) across the phenotypic spectrum of fetal growth restriction (FGR). Methods A retrospective cohort of 320 consecutive FGR pregnancies presenting at ≥ 20 weeks to a tertiary fetal medicine unit (2020–2025).
Hadas Miremberg, May Shabat, Maya Stok, Vered Offer Glasner, Adi Botvinik, Mordechai Shohat, Michal Levy, Yuval Yaron, Roee Birnbaum, Sharon Perlman, Gustavo Malinger, Karina Krajden Haratz   +11 more
wiley   +1 more source

Herbal Therapeutics in Osteoporosis: Mechanisms, Evidence, and Translational Potential

Phytotherapy Research, EarlyView.
Schematic overview of bone remodeling dysregulation in osteoporosis and the multi‐target protective role of herbal therapeutics. ABSTRACT Osteoporosis is a chronic bone disease marked by reduced density and increased fracture risk. Current treatments face limitations in safety, efficacy, and long‐term adherence, prompting interest in alternative ...
Elnaz Vafadar Moradi, Sina Vossoughinia, Zahra Yazdanpanah, Hossein Sobhani, Jalileh Jalali, Mahboobeh Ghasemzadeh Rahbardar   +5 more
wiley   +1 more source