Results 71 to 80 of about 11,645 (259)

18F‑FAPI‑04 PET/CT imaging of fibroblast activating protein reveals myocardial injury beyond cancer staging

Precision Radiation Oncology, EarlyView.
Early detection of myocardial injury in cancer patients remains challenging with conventional diagnostic tools. 18F‐FAPI‐04 PET/CT revealed abnormal myocardial uptake associated with cardiovascular risk factors and biomarkers. 18F‐FAPI‐04 PET/CT enables early, noninvasive detection of myocardial injury, providing additional clinical value beyond cancer
Jing Jia, Chuan Zhou, Shuzhen Yi, Jinsong Zheng, Chengqiang Li, Jingjie Qin, Yuchun Wei   +6 more
wiley   +1 more source

Herbal Therapeutics in Osteoporosis: Mechanisms, Evidence, and Translational Potential

Phytotherapy Research, EarlyView.
Schematic overview of bone remodeling dysregulation in osteoporosis and the multi‐target protective role of herbal therapeutics. ABSTRACT Osteoporosis is a chronic bone disease marked by reduced density and increased fracture risk. Current treatments face limitations in safety, efficacy, and long‐term adherence, prompting interest in alternative ...
Elnaz Vafadar Moradi, Sina Vossoughinia, Zahra Yazdanpanah, Hossein Sobhani, Jalileh Jalali, Mahboobeh Ghasemzadeh Rahbardar   +5 more
wiley   +1 more source

TRH-induced secretion of adrenocorticotropin and cortisol in dogs with pituitary-dependent hypercortisolism

Veterinary Quarterly, 2018
Background: In dogs, spontaneous Cushing’s syndrome is most often pituitary-dependent and caused by hypersecretion of adrenocorticotropic hormone (ACTH), resulting in increased adrenocortical glucocorticoid secretion similar to horses.
Tera Pijnacker, Marieke Knies, Sara Galac, Karin Sanders, Jan A Mol, Hans S Kooistra   +5 more
doaj   +1 more source

Marine flatworms as windows into the evolution of bilaterian neuropeptide signalling. [PDF]

J Neuroendocrinol
Abstract The evolutionary origin(s) of neuropeptide signalling is still largely unknown. It has been hypothesised that signal transmission via neuropeptides played a crucial role in the regulation of nervous systems in the bilaterian ancestor. Identification, expression and functional analyses of neuropeptides and their receptors across different ...
Nakamura R, Hamada M, Bailly X, Sakamoto H, Sakamoto T.   +4 more
europepmc   +2 more sources

Intersection of systemic lupus erythematosus and autoimmune thyroid disease: Shared pathophysiology, epidemiology, diagnosis, and management

Rheumatology &Autoimmunity, EarlyView.
A proposed mechanistic framework of systemic lupus erythematosus (SLE) and autoimmune thyroid disease (AITD) pathogenesis. In Stage 1, genetically susceptible individuals harbor risk variants within major histocompatibility complex (HLA) and non‐HLA loci that impair central and peripheral immune tolerance mechanisms within the thymic and peripheral ...
Elisa Elisa, Awalia Awalia, Deasy Ardiany, Henry Sutanto   +3 more
wiley   +1 more source

Gold‐Modified Mesoporous Carbon Enables Serum Metabolic Fingerprinting for Papillary Thyroid Carcinoma Diagnosis

Small Methods, EarlyView.
A novel MCHS‑Au‑LA substrate is developed for carbon‑gold nanostructure‐initiator mass spectrometry (C‑Au‑NIMS), which acquires metabolic fingerprints of serum samples from papillary thyroid carcinoma (PTC), benign thyroid nodules (BTN), and healthy controls (HC).
Wanwan Yi, Yida Huang, Jiayou Feng, Xiaowen Zhang, Yuheng Zhu, Kun Qian, Chang Lei, Zhongwei Lv, Chengzhong Yu   +8 more
wiley   +1 more source

Thyrotropin receptors in thyroid plasma membranes. Characteristics of thyrotropin binding and solubilization of thyrotropin receptor activity by tryptic digestion

Journal of Biological Chemistry, 1975
Biologically active bovine 125I-thyrotropin preparations have been prepared, characterized, and used to evaluate the optimal conditions for thyrotropin binding to bovine thyroid plasma membranes in vitro. Binding of 125I-TSH has a pH optimum around 6.0 and is sensitive to the choice and concentration of buffer. Binding is inhibited by salts, especially
R L, Tate, H I, Schwartz, J M, Holmes, L D, Kohn   +3 more
openaire   +2 more sources

Microplastics and the Endocrine–Metabolic Interface: Novel Diagnostic Tools Targeting Thyroid–Adipose Axis

Environmental Toxicology, EarlyView.
ABSTRACT Microplastics (MPs) have been identified as major environmental contaminants that can affect organisms directly and act as carriers of particles and chemical additives, thereby aggravating endocrine networks that coordinate metabolic homeostasis.
Sunday Amos Onikanni, Babasola Aiyeku, Marjorie Dardis Murucci, Temitope Aribigbola, Kenia Bispo, Oluwatosin Stella Olayinka, Rômulo Sperduto Dezonne, Sara Gemini Piperni, Paula Soares, Denise Pires de Carvalho, Leandro Miranda‐Alves   +10 more
wiley   +1 more source

Structural–Functional Features of the Thyrotropin Receptor: A Class A G-Protein-Coupled Receptor at Work

Frontiers in Endocrinology, 2017
The thyroid-stimulating hormone receptor (TSHR) is a member of the glycoprotein hormone receptors, a sub-group of class A G-protein-coupled receptors (GPCRs).
Gerd Krause, Gunnar Kleinau, Gunnar Kleinau, Catherine L. Worth, Annika Kreuchwig, Heike Biebermann, Patrick Marcinkowski, Patrick Scheerer   +7 more
doaj   +1 more source

From Consumer Plastics to Aquatic Toxicants: Oxidative and Endocrine Effects of Microplastics on Fathead Minnow (Pimephales promelas) Larvae

Environmental Toxicology, EarlyView.
ABSTRACT Secondary microplastics (MPs) from single‐use consumer products are rapidly becoming one of the most persistent and widespread pollutants of our time. Freshwater systems act as early sinks for MPs where fragmentation and additive leaching expose aquatic life to a broad spectrum of toxic compounds.
Alisha M. Janiga‐MacNelly, Andrew Barrick, Tham C. Hoang, Ramon Lavado   +3 more
wiley   +1 more source