Results 51 to 60 of about 20,737 (301)

Dissecting the Relation between a nuclear receptor and GATA: binding affinity studies of thyroid hormone receptor and GATA2 on TSHβ promoter. [PDF]

PLoS ONE, 2010
Much is known about how genes regulated by nuclear receptors (NRs) are switched on in the presence of a ligand. However, the molecular mechanism for gene down-regulation by liganded NRs remains a conundrum.
Ana Carolina Migliorini Figueira, Igor Polikarpov, Dmitry Veprintsev, Guilherme Martins Santos   +3 more
doaj   +1 more source

TRH: Pathophysiologic and clinical implications [PDF]

Thyrotropin releasing hormone is thought to be a tonic stimulator of the pituitary TSH secretion regulating the setpoint of the thyrotrophs to the suppressive effect of thyroid hormones. The peptide stimulates the release of normal and elevated prolactin.
A. Enjalbert, A. H. Barnett, A. H. Tashjian, A. I. Faden, A. J. L. Clark, A. Mongioi, B. M. Arafah, C. Carr, C. Faglia, C. M. Feek, C. R. Pickardt, C. R. Pickardt, C. R. Pickardt, C. R. Pickardt, C. R. Pickardt, C. R. Pickardt, D. Evain-Brion, D. S. Cooper, E. Flückiger, E. Hefco, E. Montoya, E. Roti, F. Guignier, F. Labrie, F. Massara, G. E. Shambaugh III, G. F. F. Pieters, G. Faglia, G. Faglia, G. Faglia, G. Faglia, G. Faglia, G. N. Burrow, G. P. Ceda, H. J. Chen, H. M. Fraser, J. B. Martin, J. F. Wilber, J. Habermann, J. J. Staub, J. Klindt, J. Köbberling, J. R. Sowers, J. R. Sowers, J. Sack, J.-N. Hugues, K. Hiramatsu, K. Horn, K. O. Nillson, K. W. Wenzel, K. Werder von, L. S. Jacobs, L. Wartofsky, L. Ø. Dolva, L. Ø. Dolva, L. Ø. Dolva, M. F. Scanlon, M. F. Scanlon, M. F. Scanlon, M. L'Hermite, M. M. Rabello, M. Otsuki, M. Szabo, O. Benkert, P. C. Scriba, P. C. Scriba, P. C. Scriba, P. J. Snyder, R. A. Maurer, R. Hall, R. M. Lechan, S. Ahuja, S. F. Kuku, S. Refetoff, S. Urman, St. M. Foord, T. K. Mallik, T. Mitsuma, V. B. Petersen, W. E. Cobb, W. K. Engel, W. Vale, Y. Koch   +82 more
core   +1 more source

Exposure‐adjusted safety and efficacy of GLP‐I and GLP‐1/GIP receptor agonists compared with non‐GLP‐I for weight management and type 2 diabetes: Based on FDA medical and statistical reports of 34 280 safety and 36 312 efficacy subjects

British Journal of Clinical Pharmacology, EarlyView.
Aims This work aimed to contextualize glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) and glucose‐dependent insulinotropic polypeptide (GIP) receptor agonists safety and efficacy regarding weight management (WM); we analysed Food and Drug Administration (FDA) Medical Reviews to analyse 14 medications using patient‐exposure year normalization and ...
Aishwarya Prasad, Anshu Arora, Arun Arora, Jeena Vaid, Arif Khan   +4 more
wiley   +1 more source

Glycosylation in the thyroid gland : vital aspects of glycoprotein function in thyrocyte physiology and thyroid disorders [PDF]

The key proteins responsible for hormone synthesis in the thyroid are glycosylated. Oligosaccharides strongly affect the function of glycosylated proteins.
Ewa Pocheć, Kamila Kozłowska, Marta Ząbczyńska   +2 more
core   +1 more source

A pipeline crisis or a sustainability crisis? Local and national succession planning for headteachers in England

British Educational Research Journal, EarlyView.
Abstract Recruiting and retaining school leaders is a challenge in many systems worldwide. Previous research has identified three distinct ways in which succession planning can be conceptualised and approached: a ‘pipeline’ approach seeks to match supply and demand for the posts that need filling; a ‘pool’ strategy involves proactively identifying and ...
Toby Greany, Pat Thomson, Tom Perry, Mike Collins   +3 more
wiley   +1 more source

TR alpha 2 exerts dominant negative effects on hypothalamic Trh transcription in vivo. [PDF]

PLoS ONE, 2014
Mammalian thyroid hormone receptors (TRs) have multiple isoforms, including the bona fide receptors that bind T3 (TRα1, TRβ1 and TRβ2) and a non-hormone-binding variant, TRα2.
Hajer Guissouma, Rym Ghaddab-Zroud, Isabelle Seugnet, Stéphanie Decherf, Barbara Demeneix, Marie-Stéphanie Clerget-Froidevaux   +5 more
doaj   +1 more source

Micronutrient Status in Children Suffering From Anorexia Nervosa: A Cohort of 349 Patients in a Referral Center for Eating Disorders

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Anorexia nervosa (AN) is a serious illness in which more than half of all deaths are due to malnutrition. Critically low energy and protein intake are known causes of massive weight loss, whereas micronutrient deficiencies due to a low‐calorie food pattern remain poorly characterized in children with AN. Micronutrient deficiencies in
Zenaida Iordan, Diane Morfin, Marion Bernetiere, Marie Fauchet, Noël Peretti, Bérénice Segrestin, Pierre Poinsot   +6 more
wiley   +1 more source

The role of leptin resistance in the development of thyroid neoplasia

Mìžnarodnij Endokrinologìčnij Žurnal, 2023
Background. Leptin influences energy metabolism, as it is able to inform the central nervous system about adipose tissue reserves, and is also an important neuroendocrine regulator.
O.S. Miroshnichenko
doaj   +1 more source

Comprehensive exploration of unexplained dyspnoea in subjects with normal ejection fraction and low natriuretic peptides

ESC Heart Failure, Volume 12, Issue 2, Page 879-887, April 2025.
Abstract Background Unexplained exertional dyspnoea without significant elevation of natriuretic peptides is common. One of the causes might be early heart failure with preserved ejection fraction (HFpEF). Aims This study aimed to characterize patients with exertional dyspnoea and normal/near‐to‐normal N‐terminal pro‐brain natriuretic peptide (NT ...
Emmanuelle Berthelot, Tarek Laouar, Antoine Beurnier, Nataliya Hrynchynshyn, Jean Christophe Eicher, Jean‐Michel Tartière, Patrick Jourdain, Olivier Lairez, Barnabas Gellen   +8 more
wiley   +1 more source

Allylpyrocatechol, isolated from betel leaf ameliorates thyrotoxicosis in rats by altering thyroid peroxidase and thyrotropin receptors

Scientific Reports, 2019
Allylpyrocatechol (APC) was isolated from betel leaf and its possible role in L-thyroxin (L-T4)-induced thyrotoxic rats was evaluated. The disease condition, thyrotoxicosis was confirmed by higher levels of thyroid hormones and low thyrotropin (TSH) in ...
Sunanda Panda, Malabika Sikdar, Sagarika Biswas, Rajesh Sharma, Anand Kar   +4 more
doaj   +1 more source