Results 41 to 50 of about 594,054 (285)

Leptin increases sympathetic nerve activity via induction of its own receptor in the paraventricular nucleus

eLife, 2020
Whether leptin acts in the paraventricular nucleus (PVN) to increase sympathetic nerve activity (SNA) is unclear, since PVN leptin receptors (LepR) are sparse.
Zhigang Shi, Nicole E Pelletier, Jennifer Wong, Baoxin Li, Andrei D Sdrulla, Christopher J Madden, Daniel L Marks, Virginia L Brooks   +7 more
doaj   +1 more source

Desensitization, trafficking and resensitization of the pituitary thyrotropin-releasing hormone receptor

Frontiers in Neuroscience, 2012
The pituitary receptor for thyrotropin-releasing hormone (TRH) is a calcium-mobilizing G protein-coupled receptor (GPCR) that signals through Gq/11, elevating calcium and activating protein kinase C.
Patricia M Hinkle, Austin U Gehret, Brian W Jones   +2 more
doaj   +1 more source

The Role of Hormones and Trophic Factors as Components of Preservation Solutions in Protection of Renal Function before Transplantation: A Review of the Literature

Molecules, 2020
Transplantation is currently a routine method for treating end-stage organ failure. In recent years, there has been some progress in the development of an optimal composition of organ preservation solutions, improving the vital functions of the organ and
Aneta Ostróżka-Cieślik, Barbara Dolińska   +1 more
doaj   +1 more source

In Chinese hamster ovary K1 cells dog and human thyrotropin receptors activate both the cyclic AMP and the phosphatidylinositol 4,5-bisphosphate cascades in the presence of thyrotropin and the cyclic AMP cascade in its absence.

, 1995
Thyrotropic hormone, through its human thyrotropin receptor, activates both the cyclic AMP and the phosphatidylinositol 4,5-bisphosphate-phospholipase-C cascades in human thyroid cells and in Chinese hamster ovary cells (CHO-K1) expressing this receptor.
Swillens, Stéphane, Dumont, Jacques Emile, Gérard, C., Allgeier, Anouk, Vassart, Gilbert, Van Sande, Jacqueline, Massart, Claude, Claude Massart, Anouk Allgeier, Jacques E. Dumont, Catherine Gerard, Stephane Swillens, Jacqueline Sande, Gilbert Vassart   +13 more
core   +1 more source

Gastrointestinal neurotensin receptors: lack of modulation by thyrotropin releasing hormone

, 1985
To examine whether thyrotropin releasing hormone (TRH) antagonized gastrointestinal neurotensin receptors in isolated segments of the rat fundus, duodenum and ileum, tissues were superfused, mounted and the isometric tension recorded.
J Pablo Huidobro-Toro, M Veronica Donoso
core   +1 more source

Thyrotropin receptor gene expression in oncogene-transfected rat thyroid cells: correlation between transformation, loss of thyrotropin-dependent growth, and loss of thyrotropin receptor gene expression.

, 1990
Rat FRTL-5 and PC-Cl-3 thyroid cells are continuously cultured, clonal lines which require thyrotropin to grow and function. Both can be efficiently transformed when infected with RNA or DNA viruses carrying oncogenes or when directly transfected with ...
FUSCO A, COLLETTA G, KOHN LD, AKAMIZU T, CIRAFICI AM, IKUYAMA S, GRIECO, Michele, BERLINGIERI MT, VECCHIO G., Grieco M., Grieco M, Berlingieri M.T., FUSCO, ALFREDO, VECCHIO, GIANCARLO, Kohn L.D., Vecchio G, Ikuyama S., Colletta G., Cirafici A.M., Akamizu T.   +19 more
core   +2 more sources

Genetic and Population Analyses Implicate Thyroid‐Related Regulation of RNF144B in Chondrocalcinosis

Arthritis &Rheumatology, EarlyView.
Objective Chondrocalcinosis, characterized by calcium crystal deposition within articular cartilage, affects 5% to 15% of the general population and has recently been identified as an osteoarthritis risk factor. However, its biologic pathways remain unclear.
Yahong Wu, Yanning Xu, Paul C. Okoro, Sirine Saafi, Jard de Vries, Xiaoyi Qi, Edwin H. G. Oei, Sita Bierma‐Zeinstra, Trudy Voortman, David Felson, Joyce B. J. van Meurs, Layal Chaker, J. Mark Wilkinson, Michelle S. Yau, Jessica Bertrand, Cindy G. Boer   +15 more
wiley   +1 more source

Liver X receptor regulation of thyrotropin-releasing hormone transcription in mouse hypothalamus is dependent on thyroid status. [PDF]

PLoS ONE, 2014
Reversing the escalating rate of obesity requires increased knowledge of the molecular mechanisms controlling energy balance. Liver X receptors (LXRs) and thyroid hormone receptors (TRs) are key physiological regulators of energetic metabolism. Analysing
Rym Ghaddab-Zroud, Isabelle Seugnet, Knut R Steffensen, Barbara A Demeneix, Marie-Stéphanie Clerget-Froidevaux   +4 more
doaj   +1 more source

Thyroid hormone disrupting potentials of benzisothiazolinone in embryo-larval zebrafish and rat pituitary GH3 cell line

Ecotoxicology and Environmental Safety, 2023
Benzisothiazolinone (BIT), one of the most widely used antimicrobial agents in consumer products, has frequently been detected in the water environment. The present study was conducted to determine the adverse effects of BIT on the thyroid neuroendocrine
Sujin Lee, Bareum Kwon, Junhyeok Jeong, Younglim Kho, Kyunghee Ji   +4 more
doaj   +1 more source

Exposure‐adjusted safety and efficacy of GLP‐I and GLP‐1/GIP receptor agonists compared with non‐GLP‐I for weight management and type 2 diabetes: Based on FDA medical and statistical reports of 34 280 safety and 36 312 efficacy subjects

British Journal of Clinical Pharmacology, EarlyView.
Aims This work aimed to contextualize glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) and glucose‐dependent insulinotropic polypeptide (GIP) receptor agonists safety and efficacy regarding weight management (WM); we analysed Food and Drug Administration (FDA) Medical Reviews to analyse 14 medications using patient‐exposure year normalization and ...
Aishwarya Prasad, Anshu Arora, Arun Arora, Jeena Vaid, Arif Khan   +4 more
wiley   +1 more source