Results 41 to 50 of about 11,645 (259)
Biomedical Papers, 2016 Aims: Pituitary adenomas (PA) are non-invasive benign tumors with a high autopsy prevalence. They are classified according to the type of hormone secreted (prolactin, growth hormone, adrenocorticotropin, thyrotropin, folitropin, or luteinizing hormone ...
Monika Drastikova +8 more
doaj +1 more source
Functional Characteristics of a Variant Thyrotropin Receptor [PDF]
European Journal of Biochemistry, 1996 A claim has been made that a variant of the human thyrotropin receptor in which Pro52 is replaced by Thr([Thr52]thyrotropinreceptor) is associated with autoimmune thyroid diseases and displays increased responsiveness to thyrotropin. We have analysed the functional characteristics of this variant receptor.
TONACCHERA, MASSIMO +5 more
openaire +4 more sources
Clinical Pharmacology &Therapeutics, EarlyView.Healthy volunteers (HVs) are essential for phase I trials, yet their recruitment and screening remain resource‐intensive and ethically complex. High screening failure (SF) rates highlight the need to evaluate and understand all aspects of the enrolment processes. We analyzed SF patterns in a large German HV cohort and explored participants' motivations,
Evelyn Krohmer +10 more
wiley +1 more source
Khyber Medical University JournalOBJECTIVE: To determine the significance of etiological basis of thyrotoxicosis in guiding optimal treatment selection and its correlation with age and the presence of goiter.
Fasih Iqbal +3 more
doaj +1 more source
ESC Heart Failure, Volume 12, Issue 2, Page 879-887, April 2025.Abstract Background Unexplained exertional dyspnoea without significant elevation of natriuretic peptides is common. One of the causes might be early heart failure with preserved ejection fraction (HFpEF). Aims This study aimed to characterize patients with exertional dyspnoea and normal/near‐to‐normal N‐terminal pro‐brain natriuretic peptide (NT ...
Emmanuelle Berthelot +8 more
wiley +1 more source
Dissecting the Relation between a nuclear receptor and GATA: binding affinity studies of thyroid hormone receptor and GATA2 on TSHβ promoter. [PDF]
PLoS ONE, 2010 Much is known about how genes regulated by nuclear receptors (NRs) are switched on in the presence of a ligand. However, the molecular mechanism for gene down-regulation by liganded NRs remains a conundrum.
Ana Carolina Migliorini Figueira +3 more
doaj +1 more source
Epilepsia, EarlyView.Abstract Objective Elevated body temperature may increase seizure risk, yet the relationship between thermoregulation and seizures, as well as the underlying mechanisms, remains poorly understood. We investigated whether thermoregulatory control is altered in experimental temporal lobe epilepsy (TLE), as such impairment could reduce the ability of ...
Rossella Di Sapia +19 more
wiley +1 more source
Environmental Toxicology and Chemistry, EarlyView.Abstract There is increasing concern regarding pollutants disrupting the vertebrate thyroid hormone (TH) system, which is crucial for development. Thus, identification of TH system–disrupting chemicals (THSDCs) is an important requirement in the Organisation for Economic Co‐operation and Development (OECD) testing framework.
Lisa Gölz +9 more
wiley +1 more source
TR alpha 2 exerts dominant negative effects on hypothalamic Trh transcription in vivo. [PDF]
PLoS ONE, 2014 Mammalian thyroid hormone receptors (TRs) have multiple isoforms, including the bona fide receptors that bind T3 (TRα1, TRβ1 and TRβ2) and a non-hormone-binding variant, TRα2.
Hajer Guissouma +5 more
doaj +1 more source
Equine Veterinary Journal, EarlyView.Abstract Background Insulin dysregulation (ID) and pituitary pars intermedia dysfunction (PPID) are common equine endocrinopathies detected by measurement of circulating insulin and adrenocorticotrophic hormone (ACTH) concentrations. Different assays may yield variable results, limiting comparability.
Nicola J. Menzies‐Gow +2 more
wiley +1 more source