Results 171 to 180 of about 10,636 (238)

Hyperthyroidism, acromegaly, and hyperprolactinemia in a patient with a mature plurihormonal PIT-1 lineage adenoma. [PDF]

JCEM Case Rep
Ferreira de Carvalho J, Slack D, Shrivastava R, Richardson TE, Yokoda RT, Levine AC.   +5 more
europepmc   +1 more source

Comparative Transcriptomics Provides Insight into the Neuroendocrine Regulation of Spawning in the Black-Lip Rock Oyster (<i>Saccostrea echinata</i>). [PDF]

Int J Mol Sci
Zafar MA, Suwansa-Ard S, Mellor A, Wingfield M, Reiher K, Elizur A, Cummins SF.   +6 more
europepmc   +1 more source

The thyrotropin receptor structure and interactions with autoantibodies. [PDF]

Eur Thyroid J
Rees Smith B, Núñez Miguel R, Sanders J.   +2 more
europepmc   +1 more source

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Thyrotropin binding specificity for the thyrotropin receptor

Journal of Endocrinological Investigation, 1995
Recently, highly purified bovine thyrotropin (bTSH) of pituitary origin, as well as recombinant human (h) TSH free of lutropin (LH) contamination, has been reported to activate the LH/choriogonadotropin receptor (LH/CGR). These data challenge the concept of TSH specificity for its own receptor.
Y, Nagayama, H, Yamasaki, A, Takeshita, H, Kimura, K, Ashizawa, N, Yokoyama, S, Yamashita, B, Rapoport, S, Nagataki   +8 more
openaire   +2 more sources

Thyrotropin receptor processing and interaction with thyrotropin

Biochemical and Biophysical Research Communications, 1990
In vitro transcription/translation, using rat thyrotropin receptor cDNA, results in the formation of nonglycosylated proteins able to bind thyrotropin, one of which approximates the 87 Kd size predicted for the receptor. In the presence of canine pancreatic microsomal membranes, putative glycosylation sites are modified as evidenced by digestion with ...
T, Akamizu, S, Kosugi, L D, Kohn
openaire   +2 more sources

Autoantibodies to the Thyrotropin Receptor

Endocrine Reviews, 1988
This review considers recent developments in our understanding of the properties of TRAb, particularly measurement of the antibodies and their sites of action and synthesis. Two new assay methods have allowed considerable improvements in the sensitivity, specificity, precision, and ease of measuring TRAb.
B, Rees Smith, S M, McLachlan, J, Furmaniak   +2 more
openaire   +2 more sources

The Thyrotropin Receptor

1995
This chapter has outlined the complex process required for thyroid growth and function. Both events are regulated by TSHR via a multiplicity of signals, with the aid of and requirement for a multiplicity of hormones that regulate the TSHR via receptor cross-talk: insulin, IGF-I, adrenergic receptors, and purinergic receptors.
L. D. Kohn, H. Shimura, Y. Shimura, A. Hidaka, GIULIANI, Cesidio, NAPOLITANO, Giorgio, M. Ohmori, G. Laglia, M. Saji   +8 more
openaire   +3 more sources

Thyrotropin receptor mutations as a tool to understand thyrotropin receptor action

Journal of Molecular Medicine, 2001
A large number of mutations have been identified in the thyrotropin (TSH) receptor (TSHR) gene causing human diseases. Toxic thyroid nodules are frequently associated with somatic constitutively activating TSHR mutations. Autosomal dominant non-autoimmune hyperthyroidism is caused by activating TSHR germline mutations.
P, Wonerow, S, Neumann, T, Gudermann, R, Paschke   +3 more
openaire   +2 more sources

Reactivity of Thyrotropin Receptor Autoantibodies with the Thyrotropin Receptor on Western Blots

Thyroid, 2001
Affinity purified recombinant human thyrotropin receptor (TSHR) was run on sodium dodecyl sulfate (SDS) gels and subjected to a renaturing and blotting procedure. Twenty sera from thyrotropin receptor autoantibodies (TRAb)-positive patients with a history of hyperthyroidism and 20 sera with high levels of TSH blocking activity were analyzed. Four of 20
M, Maruyama, J, Sanders, Y, Oda, A, Kiddie, J, Furmaniak, B, Rees Smith   +5 more
openaire   +2 more sources

Comparison of Recombinant Human Thyrotropin Receptors Versus Porcine Thyrotropin Receptors in the Thyrotropin Binding Inhibition Assay for Thyrotropin Receptor Autoantibodies

Thyroid, 1999
Thyrotropin receptor autoantibodies (TRAb) are most commonly measured in a thyrotropin-binding inhibition (TBI) assay using solubilized porcine thyrotropin receptors (pTSHR). Recently, we reported modifications in recombinant human thyrotropin receptor (hTSHR) production and extraction that made substitution of this antigen for the pTSHR practical.
A, Kakinuma, I, Morimoto, T, Kuroda, T, Fujihira, S, Eto, S M, McLachlan, B, Rapoport   +6 more
openaire   +2 more sources