Results 191 to 200 of about 10,636 (238)

The Thyrotropin Receptor in Graves' Disease

Thyroid, 2007
The application of molecular biology to the study of the thyrotropin receptor (TSHR) has led to major advances in our understanding of its structure, function, and relationship to the pathogenesis of Graves' disease. This review summarizes many of these features and also provides a personal perspective, questioning some assumptions and general concepts,
Basil, Rapoport, Sandra M, McLachlan
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Thyrotropin Receptor Antibodies—An Overview

Ophthalmic Plastic & Reconstructive Surgery, 2018
Purpose: Thyroid autoimmunity affects approximately 5% of the population, and its investigation relies heavily on the use of autoantibodies. Thyroid stimulating hormone receptor (TSHR) autoantibodies (TRAb) play a central role in the evaluation of Graves disease (GD), Graves ophthalmopathy (GO) and pretibial myxedema (PTM ...
Anupam, Kotwal, Marius, Stan
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Monoclonal Antibodies and the Thyrotropin Receptor

1984
Thyrotropin (TSH) is a pituitary glycoprotein hormone whose primary role is to regulate thyroid cell function (Dumont, 1971; Field, 1980; Robbins et al., 1980; Kohn et al., 1983). The interaction of TSH with a specific receptor on the thyroid cell surface induces changes in adenylate cylcase activity which result in the following tissue responses ...
Kohn, Ld, Tombaccini, D, DE LUCA, Michele, Bifulco, M, Grollman, EF, Valente, Wa   +5 more
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POSITIVE REGULATION OF HUMAN THYROTROPIN RECEPTOR mRNA BY THYROTROPIN

The Journal of Clinical Endocrinology & Metabolism, 1991
We have assessed the influence of natural and recombinant thyrotropin (TSH) on mRNA specific for the human TSH receptor (TSHR) in normal and abnormal adult human thyroid monolayer cells. Using physiological concentrations of TSH (less than 100 mU/L), a marked increase in the level of TSHR mRNA was observed within 12 hours and reached a greater than ...
G K, Huber, E S, Concepcion, P N, Graves, T F, Davies   +3 more
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Experimental autoimmunity to thyrotropin receptor

Experimental and Clinical Endocrinology & Diabetes, 2009
Since the cloning of a full length cDNA encoding the thyrotropin receptor (TSHr), several laboratories have been actively trying to develop an optimal animal model to understand the pathogenesis of TSHr mediated autoimmune diseases and have made considerable progress.
S A, Patibandla, N M, Wagle, G S, Seetharamaiah, J L, Fan, J S, Dallas, B S, Prabhakar   +5 more
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Mutations of thyrotropin receptor gene

Journal of Molecular Medicine, 1997
Thyrotropin is the primary pituitary hormone which stimulates the growth and differentiation of thyroid cells. TSH binds a specific receptor present in the plasma membrane of thyroid cells and signals the G protein transducers, which activate different effectors, mainly adenyl cyclase and phospholipase C.
PORCELLINI, ANTONIO, FENZI G, AVVEDIMNETO EV   +2 more
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Cleavage of the human thyrotropin receptor by ADAM10 is regulated by thyrotropin

Journal of Molecular Recognition, 2007
AbstractThe thyrotropin receptor (TSHR) has a unique 50 residue (317–366) ectodomain insertion that sets it apart from other glycoprotein hormone receptors (GPHRs). Other ancient members of the leucine‐rich repeat G protein‐coupled receptor (GPCR) (LGR) family do exhibit ectodomain insertions of variable lengths and sequences.
Viktoria, Kaczur, Laszlo G, Puskas, Zsuzsanna U, Nagy, Nabil, Miled, Ahmed, Rebai, Ferenc, Juhasz, Zoltan, Kupihar, Agnes, Zvara, Laszlo, Hackler, Nadir R, Farid   +9 more
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Thyrotropin Receptor Purification

1990
Thyroid stimulating hormone (thyrotropin, TSH) derived from the anterior pituitary gland exerts its action by binding to specific receptors on thyroid follicular cells (Moore and Wolff, 1974; Kotani et al., 1975; Amir et al., 1976; Rees Smith et al., 1977; Pekonen and Weintraub, 1979). Binding initiates a sequence of processes (including stimulation of
Petu J. Leedman, Leonard C. Harrison
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Cleavage of the thyrotropin receptor

Journal of Endocrinological Investigation, 2001
N M, Islam, C L, Hew, V, Kaczur, N R, Farid   +3 more
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Thyrotropin Receptor Antibodies

1981
The thyrotropin (TSH) receptor is an integral membrane protein which contains 2 subunits linked by a disulphide bridge. The A subunit (mol. wt. 50,000) is water soluble and forms the binding site for TSH, whereas the B subunit (mol. wt. 30,000) penetrates the lipid bilayer and probably forms the site for interaction with adenylate cyclase ...
openaire   +1 more source