Results 191 to 200 of about 10,411 (253)

Thyrotropin binding specificity for the thyrotropin receptor

Journal of Endocrinological Investigation, 1995
Recently, highly purified bovine thyrotropin (bTSH) of pituitary origin, as well as recombinant human (h) TSH free of lutropin (LH) contamination, has been reported to activate the LH/choriogonadotropin receptor (LH/CGR). These data challenge the concept of TSH specificity for its own receptor.
Y, Nagayama, H, Yamasaki, A, Takeshita, H, Kimura, K, Ashizawa, N, Yokoyama, S, Yamashita, B, Rapoport, S, Nagataki   +8 more
openaire   +2 more sources

Thyrotropin receptor processing and interaction with thyrotropin

Biochemical and Biophysical Research Communications, 1990
In vitro transcription/translation, using rat thyrotropin receptor cDNA, results in the formation of nonglycosylated proteins able to bind thyrotropin, one of which approximates the 87 Kd size predicted for the receptor. In the presence of canine pancreatic microsomal membranes, putative glycosylation sites are modified as evidenced by digestion with ...
T, Akamizu, S, Kosugi, L D, Kohn
openaire   +2 more sources

Comparison of Recombinant Human Thyrotropin Receptors Versus Porcine Thyrotropin Receptors in the Thyrotropin Binding Inhibition Assay for Thyrotropin Receptor Autoantibodies

Thyroid, 1999
Thyrotropin receptor autoantibodies (TRAb) are most commonly measured in a thyrotropin-binding inhibition (TBI) assay using solubilized porcine thyrotropin receptors (pTSHR). Recently, we reported modifications in recombinant human thyrotropin receptor (hTSHR) production and extraction that made substitution of this antigen for the pTSHR practical.
A, Kakinuma, I, Morimoto, T, Kuroda, T, Fujihira, S, Eto, S M, McLachlan, B, Rapoport   +6 more
openaire   +2 more sources

The Thyrotropin Receptor

1995
This chapter has outlined the complex process required for thyroid growth and function. Both events are regulated by TSHR via a multiplicity of signals, with the aid of and requirement for a multiplicity of hormones that regulate the TSHR via receptor cross-talk: insulin, IGF-I, adrenergic receptors, and purinergic receptors.
L. D. Kohn, H. Shimura, Y. Shimura, A. Hidaka, GIULIANI, Cesidio, NAPOLITANO, Giorgio, M. Ohmori, G. Laglia, M. Saji   +8 more
openaire   +3 more sources

Thyrotropin receptor mutations as a tool to understand thyrotropin receptor action

Journal of Molecular Medicine, 2001
A large number of mutations have been identified in the thyrotropin (TSH) receptor (TSHR) gene causing human diseases. Toxic thyroid nodules are frequently associated with somatic constitutively activating TSHR mutations. Autosomal dominant non-autoimmune hyperthyroidism is caused by activating TSHR germline mutations.
P, Wonerow, S, Neumann, T, Gudermann, R, Paschke   +3 more
openaire   +2 more sources

Thyrotropin Receptor Antibodies in Early Pregnancy

The Journal of Clinical Endocrinology & Metabolism, 2022
Abstract Context Thyrotropin (TSH) receptor antibodies (TRAb) are important when distinguishing between Graves’ and gestational hyperthyroidism, but sparse evidence exists on the recommended cutoff during pregnancy.
Nanna Maria Uldall Torp, Niels Henrik Bruun, Peter Astrup Christensen, Aase Handberg, Stig Andersen, Stine Linding Andersen   +5 more
openaire   +3 more sources

Thyrotropin Receptor

1990
This paper deals with the isolation, purification and functional characterization of the TSH receptor.
Akamizu T., DE LUCA, Michele, Kohn L. D.
openaire   +2 more sources

Thyrotropin Receptors and Gangliosides

1980
Recent studies (1, 2, 28–30, 33–35) have implicated ganglio-sides in the receptor recognition process for thyrotropin (TSH) and have led to the hypothesis (15–17, 19) that the TSH receptor is structurally and functionally related to receptors for other ligands which interact with gangliosides in vitro, i.e., cholera toxin, tetanus toxin, and interferon.
L D, Kohn, E, Consiglio, M J, DeWolf, E F, Grollman, F D, Ledley, G, Lee, N P, Morris   +6 more
openaire   +2 more sources

Thyrotropin Receptor Antibodies—An Overview

Ophthalmic Plastic & Reconstructive Surgery, 2018
Purpose: Thyroid autoimmunity affects approximately 5% of the population, and its investigation relies heavily on the use of autoantibodies. Thyroid stimulating hormone receptor (TSHR) autoantibodies (TRAb) play a central role in the evaluation of Graves disease (GD), Graves ophthalmopathy (GO) and pretibial myxedema (PTM ...
Anupam, Kotwal, Marius, Stan
openaire   +2 more sources

Bioassays for thyrotropin receptor autoantibodies

Best Practice & Research Clinical Endocrinology & Metabolism, 2023
Bioassays using animal models were essential tools in the discovery of thyrotropin and in enhancing our understanding of the physiology of the pituitary-thyroid axis. These same bioassays were also instrumental in the discovery of autoantibodies to the thyrotropin receptor (TSH-R-Ab) and in identifying their role in the pathophysiology of Graves ...
openaire   +2 more sources