Results 11 to 20 of about 2,380,315 (334)

Transferrin: Biology and Use in Receptor-Targeted Nanotherapy of Gliomas

ACS Omega, 2021
Gliomas constitute 80% of malignant brain tumors. The survival rate of patients diagnosed with malignant gliomas is only 34.4%, as seen in both adults as well as children.
Tejaswi Koneru, Eva McCord, S. Pawar, K. Tatiparti, S. Sau, A. Iyer   +5 more
semanticscholar   +1 more source

Subcellular trafficking and transcytosis efficacy of different receptor types for therapeutic antibody delivery at the blood‒brain barrier

Fluids and Barriers of the CNS, 2023
Here, we report an experimental setup to benchmark different receptors for targeted therapeutic antibody delivery at the blood–brain barrier. We used brain capillary endothelial-like cells derived from induced pluripotent stem cells (hiPSC-BECs) as a ...
Mikkel Roland Holst, Nienke Marije de Wit, Burak Ozgür, Andreas Brachner, Kathrine Hyldig, Antje Appelt-Menzel, Hannah Sleven, Zameel Cader, Helga Eveline de Vries, Winfried Neuhaus, Allan Jensen, Birger Brodin, Morten Schallburg Nielsen   +12 more
doaj   +1 more source

Quantum Dots Encapsulated with Canine Parvovirus-Like Particles Improving the Cellular Targeted Labeling. [PDF]

PLoS ONE, 2015
Quantum dots (QDs) have a promising prospect in live-cell imaging and sensing because of unique fluorescence features. QDs aroused significant interest in the bio-imaging field through integrating the fluorescence properties of QDs and the delivery ...
Dan Yan, Bin Wang, Shiqi Sun, Xia Feng, Ye Jin, Xueping Yao, Suizhong Cao, Huichen Guo   +7 more
doaj   +1 more source

RELATIONSHIP OF CHANGES IN HEMATOLOGICAL AND BIOCHEMICAL INDICATORS OF PERIPHERAL BLOOD WITH THE TRANSFERRIN CONCENTRATION AND CD71+ LYMPHOCYTE COUNT

Siberian Journal of Life Sciences and Agriculture, 2022
Transferrin is an essential component of cell growth and metabolic processes that require iron. An increase in the expression of transferrin receptors on lymphocytes ensures their differentiation, maturation and activation of proliferation.
Veronika V. Patrakeeva, Liliya K. Dobrodeeva, Natal’ya P. Geshavec   +2 more
doaj   +1 more source

Heterotypic interactions between transferrin receptor and transferrin receptor 2 [PDF]

Blood, 2003
Cellular iron uptake in most tissues occurs via endocytosis of diferric transferrin (Tf) bound to the transferrin receptor (TfR). Recently, a second transferrin receptor, transferrin receptor 2 (TfR2), has been identified and shown to play a critical role in iron metabolism.
Vogt, Todd M, Blackwell, Aaron D, Giannetti, Anthony M, Bjorkman, Pamela J, Enns, Caroline A   +4 more
openaire   +4 more sources

A method to selectively internalise submicrometer boron carbide particles into cancer cells using surface transferrin conjugation for developing a new boron neutron capture therapy agent

Journal of Experimental Nanoscience, 2020
With the goal of developing a new type of boron neutron capture therapy (BNCT) agent, selective internalisation of submicrometer boron carbide spherical particles into cancer cells via surface transferrin conjugation is demonstrated and confirmed in ...
Takuma Tsuji, Hiroshi Yoshitomi, Yoshie Ishikawa, Naoto Koshizaki, Motoshi Suzuki, Jiro Usukura   +5 more
doaj   +1 more source

Structure of the Human Transferrin Receptor-Transferrin Complex [PDF]

Cell, 2004
Iron, insoluble as free Fe(3+) and toxic as free Fe(2+), is distributed through the body as Fe(3+) bound to transferrin (Tf) for delivery to cells by endocytosis of its complex with transferrin receptor (TfR). Although much is understood of the transferrin endocytotic cycle, little has been uncovered of the molecular details underlying the formation of
Olga Zak, Stephen C. Harrison, Stephen C. Harrison, Thomas Walz, Philip Aisen, Yifan Cheng   +5 more
openaire   +3 more sources

Endosomal LC3C-pathway selectively targets plasma membrane cargo for autophagic degradation

Nature Communications, 2022
Autophagy can selectively target cargo for degradation. Here the authors map the proximal interactome of ATG8-paralogs LC3B and LC3C uncovering an LC3C-Endocytic-Associated-Pathway that selectively recruits internalized plasma membrane cargo, Met and ...
Paula P. Coelho, Geoffrey G. Hesketh, Annika Pedersen, Elena Kuzmin, Anne-Marie N. Fortier, Emily S. Bell, Colin D. H. Ratcliffe, Anne-Claude Gingras, Morag Park   +8 more
doaj   +1 more source

Transferrin receptor expression and the regulation of placental iron uptake [PDF]

, 1991
Placental transferrin receptors, located at the apical side of syncytiotrophoblast, mediate placental iron uptake. Regulation of transferrin receptors on the fetal-maternal exchange area could be a major determinant in the regulation of trans-placental ...
Baert, M.R.M. (Miranda), Bierings, M. (Marc), Dijk, J.P. (Johannes) van, Eijk, H.G. (Henk) van   +3 more
core   +1 more source

Transferrinfection. A Highly Efficient Way to Express Gene Constructs in Eukaryotic Cells [PDF]

, 1992
No abstract ...
Atherton, Atherton, Chardonnet, CHRISTIAN PLANK, Cotten, Cotten, Cotten, Curiel, Curiel, DAVID T. CURIEL, Davidson, Day, ERNST WAGNER, Folk, Jones, Krol, KURT ZATLOUKAL, Lim, MATT COTTEN, MAX L. BIRNSTIEL, Mol, Pastan, PETER STEINLEIN, Powell, Sambrook, Sipe, Spiess, STEPHEN PHILLIPS, Stout, Stryer, Wagner, Wagner, Wharton, Wu, Wu, Zenke   +35 more
core   +1 more source