Results 11 to 20 of about 48,638 (261)

RELATIONSHIP OF CHANGES IN HEMATOLOGICAL AND BIOCHEMICAL INDICATORS OF PERIPHERAL BLOOD WITH THE TRANSFERRIN CONCENTRATION AND CD71+ LYMPHOCYTE COUNT

Siberian Journal of Life Sciences and Agriculture, 2022
Transferrin is an essential component of cell growth and metabolic processes that require iron. An increase in the expression of transferrin receptors on lymphocytes ensures their differentiation, maturation and activation of proliferation.
Veronika V. Patrakeeva, Liliya K. Dobrodeeva, Natal’ya P. Geshavec   +2 more
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A method to selectively internalise submicrometer boron carbide particles into cancer cells using surface transferrin conjugation for developing a new boron neutron capture therapy agent

Journal of Experimental Nanoscience, 2020
With the goal of developing a new type of boron neutron capture therapy (BNCT) agent, selective internalisation of submicrometer boron carbide spherical particles into cancer cells via surface transferrin conjugation is demonstrated and confirmed in ...
Takuma Tsuji, Hiroshi Yoshitomi, Yoshie Ishikawa, Naoto Koshizaki, Motoshi Suzuki, Jiro Usukura   +5 more
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Endosomal LC3C-pathway selectively targets plasma membrane cargo for autophagic degradation

Nature Communications, 2022
Autophagy can selectively target cargo for degradation. Here the authors map the proximal interactome of ATG8-paralogs LC3B and LC3C uncovering an LC3C-Endocytic-Associated-Pathway that selectively recruits internalized plasma membrane cargo, Met and ...
Paula P. Coelho, Geoffrey G. Hesketh, Annika Pedersen, Elena Kuzmin, Anne-Marie N. Fortier, Emily S. Bell, Colin D. H. Ratcliffe, Anne-Claude Gingras, Morag Park   +8 more
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Magnetic and Fluorescent Dual-Labeled Genetically Encoded Targeted Nanoparticles for Malignant Glioma Cell Tracking and Drug Delivery

Pharmaceutics, 2023
Human glioblastoma multiforme (GBM) is a primary malignant brain tumor, a radically incurable disease characterized by rapid growth resistance to classical therapies, with a median patient survival of about 15 months.
Anna N. Gabashvili, Nelly S. Chmelyuk, Vera V. Oda, Maria K. Leonova, Viktoria A. Sarkisova, Polina A. Lazareva, Alevtina S. Semkina, Nikolai A. Belyakov, Timur R. Nizamov, Petr I. Nikitin   +9 more
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Insights from targeting transferrin receptors to develop vaccines for pathogens of humans and food production animals

Frontiers in Cellular and Infection Microbiology, 2023
While developing vaccines targeting surface transferrin receptor proteins in Gram-negative pathogens of humans and food production animals, the common features derived from their evolutionary origins has provided us with insights on how improvements ...
Nikolas F. Ewasechko, Somshukla Chaudhuri, Anthony B. Schryvers, Anthony B. Schryvers   +3 more
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Investigation into the Antigenic Properties and Contributions to Growth in Blood of the Meningococcal Haemoglobin Receptors, HpuAB and HmbR. [PDF]

PLoS ONE, 2015
Acquisition of iron from host complexes is mediated by four surface-located receptors of Neisseria meningitidis. The HmbR protein and heterodimeric HpuAB complex bind to haemoglobin whilst TbpBA and LbpBA bind iron-loaded transferrin and lactoferrin ...
Fadil A Bidmos, Hannah Chan, Uta Praekelt, Isfahan Tauseef, Youssif M Ali, Edward B Kaczmarski, Ian Feavers, Christopher D Bayliss   +7 more
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Structure of the Human Transferrin Receptor-Transferrin Complex [PDF]

Cell, 2004
Iron, insoluble as free Fe(3+) and toxic as free Fe(2+), is distributed through the body as Fe(3+) bound to transferrin (Tf) for delivery to cells by endocytosis of its complex with transferrin receptor (TfR). Although much is understood of the transferrin endocytotic cycle, little has been uncovered of the molecular details underlying the formation of
Cheng, Yifan, Zak, Olga, Aisen, Philip, Harrison, Stephen C, Walz, Thomas   +4 more
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Influence of the genetic makeup of common carp on the expression of iron-related genes during Trypanoplasma borreli infection

Journal of Veterinary Research, 2018
Genes related to iron metabolism play an important role in inflammatory response. The objective of this study was to investigate the role of ferritin, transferrin receptors 1a and 1b, and transferrin genes in the response to blood parasite infection in ...
Kamińska-Gibas Teresa, Irnazarow Ilgiz, Szczygieł Joanna, Jurecka Patrycja   +3 more
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Regulation of cell surface transferrin receptor-2 by iron-dependent cleavage and release of a soluble form

Haematologica, 2015
Transferrin receptor-2 is a transmembrane protein whose expression is restricted to hepatocytes and erythroid cells. Transferrin receptor-2 has a regulatory function in iron homeostasis, since its inactivation causes systemic iron overload.
Alessia Pagani, Maud Vieillevoye, Antonella Nai, Marco Rausa, Meriem Ladli, Catherine Lacombe, Patrick Mayeux, Frédérique Verdier, Clara Camaschella, Laura Silvestri   +9 more
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Factors associated with iron deficiency in heart failure

Кардиоваскулярная терапия и профилактика, 2023
Aim. To establish the factors associated with iron deficiency (ID) in pa- tients with heart failure (HF).Material and methods. We examined 294 patients with NYHA class II-IV HF as follows: 213 — with ID, 81 — without ID. All patients underwent a clinical
M. P. Smirnova, P. A. Chizhov
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