Results 21 to 30 of about 2,380,315 (334)

Crossing the Iron Gate: Why and How Transferrin Receptors Mediate Viral Entry.

Annual review of nutrition, 2018
Because both the host and pathogen require iron, the innate immune response carefully orchestrates control over iron metabolism to limit its availability during times of infection. Nutritional iron deficiency can impair host immunity, while iron overload
M. Wessling-Resnick
semanticscholar   +1 more source

DISTRIBUTION OF TRANSFERRIN AND TRANSFERRIN RECEPTORS IN THE RABBIT PLACENTA [PDF]

Quarterly Journal of Experimental Physiology, 1983
The quantity and distribution of transferrin and transferrin‐binding sites in the placenta were investigated in rabbits on the 28th‐29th days of pregnancy. The animals were injected intravenously with a mixture of 59Fe‐125I‐labelled rabbit diferric transferrin and 131I‐labelled rabbit albumin.
Erica Baker, F.M. van Bockxmeer, Evan H. Morgan   +2 more
openaire   +3 more sources

Magnetic and Fluorescent Dual-Labeled Genetically Encoded Targeted Nanoparticles for Malignant Glioma Cell Tracking and Drug Delivery

Pharmaceutics, 2023
Human glioblastoma multiforme (GBM) is a primary malignant brain tumor, a radically incurable disease characterized by rapid growth resistance to classical therapies, with a median patient survival of about 15 months.
Anna N. Gabashvili, Nelly S. Chmelyuk, Vera V. Oda, Maria K. Leonova, Viktoria A. Sarkisova, Polina A. Lazareva, Alevtina S. Semkina, Nikolai A. Belyakov, Timur R. Nizamov, Petr I. Nikitin   +9 more
doaj   +1 more source

Anticancer drug delivery with transferrin targeted polymeric chitosan vesicles [PDF]

, 2004
The study reports the initial biological evaluation of targeted polymeric glycol chitosan vesicles as carrier systems for doxorubicin (Dox). Transferrin (Tf) was covalently bound to the Dox-loaded palmitoylated glycol chitosan (GCP) vesicles using ...
Couet, William, Dufès, Christine, Muller, Jean-Marc, Olivier, Jean-Christophe, Schätzlein, Andreas G., Uchegbu, I.F.   +5 more
core   +1 more source

Transferrin Receptors TfR1 and TfR2 Bind Transferrin through Differing Mechanisms.

Biochemistry, 2018
Hereditary hemochromatosis (HH), a disease marked by chronic iron overload from insufficient expression of the hormone hepcidin, is one of the most common genetic diseases. One form of HH (type III) results from mutations in transferrin receptor-2 (TfR2).
M. Kleven, S. Jue, C. Enns
semanticscholar   +1 more source

Gene transfer into hepatocytes using asialoglycoprotein receptor mediated endocytosis of DNA complexed with an artificial tetra-antennary galactose ligand [PDF]

, 1992
We have constructed an artificial ligand for the hepatocyte-specific asialoglycoprotein receptor for the purpose of generating a synthetic delivery system for DNA.
Ashwell G., Atherton E., Atherton E., Baenziger J. U., Christian Plank, Connolly D. T., Corley Cain C., Curiel D. T., DeWet J., Ellman G. L., Ernst Wagner, Gotten M., Gotten M., Gotten M., Huckett B., Karl Mechtler, Kempen H. J. M., Knowles B. B., Kurt Zatloukal, Lee Y. C., Matt Cotten, Orrantia E., Patek P.Q., Rosenkranz A. A., Seifter S., Severne Y., Spiess M., Tam J. P., Wagner E., Wagner E., Wagner E., Wagner E., Wharton S. A., Wu C., Wu G. Y., Zatloukal K., Zenke M.   +36 more
core   +1 more source

Targeting transferrin receptors at the blood-brain barrier improves the uptake of immunoliposomes and subsequent cargo transport into the brain parenchyma

Scientific Reports, 2017
Drug delivery to the brain is hampered by the presence of the blood-brain barrier, which excludes most molecules from freely diffusing into the brain, and tightly regulates the active transport mechanisms that ensure sufficient delivery of nutrients to ...
K. B. Johnsen, A. Burkhart, Fredrik Melander, P. Kempen, Jonas Bruun Vejlebo, P. Siupka, M. Nielsen, T. Andresen, T. Moos   +8 more
semanticscholar   +1 more source

Chiral Surface of Nanoparticles Determines the Orientation of Adsorbed Transferrin and Its Interaction with Receptors.

ACS Nano, 2017
When nanoparticles are exposed to a physiological environment, a "protein corona" is formed that greatly determines their biological fate. Adsorption of proteins could be influenced by chiral surfaces of nanoparticles; however, very few quantitative ...
Xinyi Wang, Mingzhe Wang, Rong Lei, Shuifang Zhu, Yuliang Zhao, Chunying Chen   +5 more
semanticscholar   +1 more source

Investigation into the Antigenic Properties and Contributions to Growth in Blood of the Meningococcal Haemoglobin Receptors, HpuAB and HmbR. [PDF]

PLoS ONE, 2015
Acquisition of iron from host complexes is mediated by four surface-located receptors of Neisseria meningitidis. The HmbR protein and heterodimeric HpuAB complex bind to haemoglobin whilst TbpBA and LbpBA bind iron-loaded transferrin and lactoferrin ...
Fadil A Bidmos, Hannah Chan, Uta Praekelt, Isfahan Tauseef, Youssif M Ali, Edward B Kaczmarski, Ian Feavers, Christopher D Bayliss   +7 more
doaj   +1 more source

Insights from targeting transferrin receptors to develop vaccines for pathogens of humans and food production animals

Frontiers in Cellular and Infection Microbiology, 2023
While developing vaccines targeting surface transferrin receptor proteins in Gram-negative pathogens of humans and food production animals, the common features derived from their evolutionary origins has provided us with insights on how improvements ...
Nikolas F. Ewasechko, Somshukla Chaudhuri, Anthony B. Schryvers, Anthony B. Schryvers   +3 more
doaj   +1 more source