Results 21 to 30 of about 48,638 (261)

CD71 (Transferrin Receptor) [PDF]

American Journal of Clinical Pathology, 2010
Abstract Accurate analysis of the erythroid lineage is essential in evaluating bone marrow biopsy specimens and can be particularly challenging in the setting of dyserythropoiesis. Transferrin receptor (CD71) mediates the uptake of transferrin-iron complexes and is highly expressed on the surface of cells of the erythroid lineage ...
Derek K. Marsee, Geraldine S. Pinkus, Hongbo Yu   +2 more
openaire   +1 more source

Macrophage colony-stimulating factor differentially regulates low density lipoprotein and transferrin receptors

Journal of Lipid Research, 2004
Endocytosis mediated by both LDL receptors (LDLRs) and transferrin receptors (TfRs) occurs in clathrin-coated pits and requires specific tyrosine-based internalization sequences located in the cytoplasmic domain of these receptors.
Liqin Du, Steven R. Post
doaj   +1 more source

Identification of Transferrin Receptor 1 (TfR1) Overexpressed in Lung Cancer Cells, and Internalization of Magnetic Au-CoFe₂O₄ Core-Shell Nanoparticles Functionalized with Its Ligand in a Cellular Model of Small Cell Lung Cancer (SCLC)

Pharmaceutics, 2022
Lung cancer is, currently, one of the main malignancies causing deaths worldwide. To date, early prognostic and diagnostic markers for small cell lung cancer (SCLC) have not been systematically and clearly identified, so most patients receive standard ...
Rocío Villalobos-Manzo, Emmanuel Ríos-Castro, José Manuel Hernández-Hernández, Goldie Oza, Mauricio A. Medina, José Tapia-Ramírez   +5 more
doaj   +1 more source

Some aspects of the transport system of iron metabolism depending on the degree of iron overload syndrome in children with chronic hepatitis B

Детские инфекции (Москва), 2019
Objective: to study the status of markers of the transport system of iron metabolism and the marker profile of HBV infection, depending on the degree of iron overload syndrome in children with chronic hepatitis B.The object of the study were 1 85 ...
F. I. Inoyatova, Kh. M. Kadyrkhodjaeva, G. Z. Inogamova, A. Kh. Akhmedova, N. K. Valieva, F. G. Abdullaeva, N. A. Ikramova   +6 more
doaj   +1 more source

Cell-Based, High-Content Screen for Receptor Internalization, Recycling and Intracellular Trafficking

BioTechniques, 2000
A variety of physiologically important receptors are internalized and then recycled back to the plasma membrane by the endocytic recycling compartment. These include the transferrin receptor and many G-protein coupled receptors (GPCRs).
R.N. Ghosh, Y.-T. Chen, R. DeBiasio, R.L. DeBiasio, B.R. Conway, L.K. Minor, K.T. Demarest   +6 more
doaj   +1 more source

Two Interconvertible Folds Modulate the Activity of a DNA Aptamer Against Transferrin Receptor

Molecular Therapy: Nucleic Acids, 2014
Thanks to their ability to recognize biomolecular targets with high affinity and specificity, nucleic acid aptamers are increasingly investigated as diagnostic and therapeutic tools, particularly when their targets are cell-surface receptors.
David Porciani, Giovanni Signore, Laura Marchetti, Paolo Mereghetti, Riccardo Nifosì, Fabio Beltram   +5 more
doaj   +1 more source

Contributions of HFE polymorphisms to brain and blood iron load, and their links to cognitive and motor function in healthy adults

Neuropsychopharmacology Reports, 2021
Background Brain iron overload is linked to brain deterioration, and cognitive and motor impairment in neurodegenerative disorders and normal aging. Mutations in the HFE gene are associated with iron dyshomeostasis and are risk factors for peripheral ...
Grégoria Kalpouzos, Francesca Mangialasche, Farshad Falahati, Erika J Laukka, Goran Papenberg   +4 more
doaj   +1 more source

Two peptides targeting endothelial receptors are internalized into murine brain endothelial cells.

PLoS ONE, 2021
The blood-brain barrier (BBB) is one of the main obstacles for therapies targeting brain diseases. Most macromolecules fail to pass the tight BBB, formed by brain endothelial cells interlinked by tight junctions.
Diána Hudecz, Sara Björk Sigurdardóttir, Sarah Christine Christensen, Casper Hempel, Andrew J Urquhart, Thomas Lars Andresen, Morten S Nielsen   +6 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Iron-loaded transferrin (Tf) is detrimental whereas iron-free Tf confers protection against brain ischemia by modifying blood Tf saturation and subsequent neuronal damage

Redox Biology, 2018
Despite transferrin being the main circulating carrier of iron in body fluids, and iron overload conditions being known to worsen stroke outcome through reactive oxygen species (ROS)-induced damage, the contribution of blood transferrin saturation (TSAT)
Nuria DeGregorio-Rocasolano, Octavi Martí-Sistac, Jovita Ponce, María Castelló-Ruiz, Mònica Millán, Verónica Guirao, Isaac García-Yébenes, Juan B. Salom, Pedro Ramos-Cabrer, Enrique Alborch, Ignacio Lizasoain, José Castillo, Antoni Dávalos, Teresa Gasull   +13 more
doaj   +1 more source