Results 121 to 130 of about 89,614 (169)
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Transforming growth factor -beta receptor signaling in cancer
Frontiers in Bioscience, 2005Transforming growth factor-beta (TGF-beta) is an ubiquitous cytokine that affects various biological processes, such as regulation of cell proliferation, immune responses, growth, differentiation, angiogenesis, and apoptosis of various cell types.
Satya, Narayan +2 more
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The Journal of Immunology, 1991
Abstract Participation of human polymorphonuclear neutrophils in the inflammatory response is mediated, in part, by soluble factors such as chemotactic peptides and cytokines. Although the cytokine, transforming growth factor beta (TGF-beta), has been shown to recruit monocytes and promote the inflammatory process, its effects on ...
M E, Brandes +3 more
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Abstract Participation of human polymorphonuclear neutrophils in the inflammatory response is mediated, in part, by soluble factors such as chemotactic peptides and cytokines. Although the cytokine, transforming growth factor beta (TGF-beta), has been shown to recruit monocytes and promote the inflammatory process, its effects on ...
M E, Brandes +3 more
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Transforming growth factor-β receptors and binding proteoglycans
Journal of Cell Science, 1990ABSTRACT Transforming growth factors-beta (TGFs-β) are representative of a superfamily whose members were first identified as regulators of morphogenesis and differentiation, and subsequently found to be structurally related. Other members of the family include the activins and inhibins, BMPs, MIS, the DPP-C gene product and Vg-1.
F T, Boyd +4 more
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Heterobicyclic inhibitors of transforming growth factor beta receptor I (TGFβRI)
Bioorganic & Medicinal Chemistry, 2018The TGFβ-TGFβR signaling pathway has been reported to play a protective role in the later stages of tumorigenesis via increasing immunosuppressive Treg cells and facilitating the epithelial to mesenchymal transition (EMT). Therefore, inhibition of TGFβR has the potential to enhance antitumor immunity.
Lalgudi S. Harikrishnan +20 more
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Multiple type-? transforming growth factors and their receptors
Journal of Cellular Physiology, 1987Type beta transforming growth factors are a group of homologous structurally related polypeptides that act on a wide variety of cell types to alter their proliferative and phenotypic properties. TGF-beta s form a group within a larger family of polypeptides that control developmental processes in organisms from humans to Drosophila.
J, Massagué +3 more
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The transforming growth factor-β superfamily of receptors
Cytokine & Growth Factor Reviews, 2004The transforming growth factor-beta (TGF-beta) superfamily of receptors comprises two groups of transmembrane serine-threonine kinase receptors, so called type I, and type II receptors, that are activated following engagement by members of the TGF-beta superfamily of ligands.
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Transforming growth factor betas and their receptors in human liver cirrhosis
European Journal of Gastroenterology & Hepatology, 1998Transforming growth factor betas (TGF-betas) are a group of homologous polypeptides that exert pleiotropic effects on various cell types and stimulate the formation of extracellular matrix and fibrosis. To evaluate whether TGF-beta isoforms (TGF-beta1, TGF-beta2 and TGF-beta3) and their receptors (types I-III) are also of importance in the ...
H U, Baer +7 more
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Journal of Molecular Medicine, 2002
Numerous studies have demonstrated the involvement of the transforming growth factor (TGF) isoform beta(1) in the pathogenesis of renal fibroproliferative diseases. Although in vitro studies suggest that TGF-beta(2) is equally potent to TGF-beta(1) in terms of its antimitogenic and fibrogenic effects, much less is known about the regulation of TGF-beta(
Andrea, Hartner +4 more
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Numerous studies have demonstrated the involvement of the transforming growth factor (TGF) isoform beta(1) in the pathogenesis of renal fibroproliferative diseases. Although in vitro studies suggest that TGF-beta(2) is equally potent to TGF-beta(1) in terms of its antimitogenic and fibrogenic effects, much less is known about the regulation of TGF-beta(
Andrea, Hartner +4 more
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The American journal of pathology, 1992
The transforming growth factor-beta (TGF beta) family in mammals includes three closely related peptides that influence proliferation and numerous physiologic processes in most mesenchymal cells. In this study, Northern blots, immunohistochemistry, TGF beta radioreceptor assays, TGF beta receptor affinity labeling and [3H] thymidine incorporation were ...
M D, Johnson +3 more
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The transforming growth factor-beta (TGF beta) family in mammals includes three closely related peptides that influence proliferation and numerous physiologic processes in most mesenchymal cells. In this study, Northern blots, immunohistochemistry, TGF beta radioreceptor assays, TGF beta receptor affinity labeling and [3H] thymidine incorporation were ...
M D, Johnson +3 more
openaire +1 more source