Results 131 to 140 of about 89,614 (169)
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A System of Transforming Growth Factor-β Receptors
American Journal of Respiratory Cell and Molecular Biology, 1991The initial interaction of polypeptide growth factors with a target cell is the binding to specific receptors present on the plasma membrane. The study, definition, and characterization of these receptors is essential for understanding the mechanism by which growth factors elicit their biologic effects. The identification of receptors that bind members
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Transforming Growth Factor-β: Latent Forms, Binding Proteins and Receptors
Growth Factors, 1993(1993). Transforming Growth Factor-β: Latent Forms, Binding Proteins and Receptors. Growth Factors: Vol. 8, No. 1, pp. 11-22.
K, Miyazono, H, Ichijo, C H, Heldin
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Transforming Growth Factor Beta-Receptor Type II (TGFβR2)
2016Transforming growth factor beta-receptor type II (TGFβR2) is a human tumour-suppressor gene consisting of seven exons and with a locus at chromosome 3p22. The TGFβR2 gene encodes transforming growth factor beta-receptor Type II (TβR-II), a transmembrane protein that contains serine-threonine protein kinases in its intracellular domain.
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Clinical cancer research : an official journal of the American Association for Cancer Research, 1999
Several humoral growth factors may contribute to the development and growth of AIDS-associated Kaposi's sarcoma (KS). They are either provided by chronically activated cells of the immune system or in an autocrine/paracrine manner by the neoplastic cells themselves.
I F, Ciernik +5 more
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Several humoral growth factors may contribute to the development and growth of AIDS-associated Kaposi's sarcoma (KS). They are either provided by chronically activated cells of the immune system or in an autocrine/paracrine manner by the neoplastic cells themselves.
I F, Ciernik +5 more
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The soluble transforming growth factor-β receptor: Advantages and applications
The International Journal of Biochemistry & Cell Biology, 2009Transforming growth factor-beta (TGF-beta) is a cytokine that plays a pivotal role in growth, differentiation, development, immune response and wound healing. TGF-beta is upregulated following wound infliction and inflammation, and plays an important role in the production of extracellular matrix proteins that contribute to tissue repair.
Leileata M, Russo +2 more
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Differential expression of transforming growth factor-beta receptors in rat kidney development
American Journal of Physiology-Renal Physiology, 1997Transforming growth factor-beta 1 (TGF-beta 1) is strongly expressed during embryogenesis and in sites undergoing intense development and morphogenesis. Two receptor serine/threonine kinases (types I and II) have been identified as signal-transducing TGF-beta receptors.
M E, Choi, A, Liu, B J, Ballermann
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Effects of transforming growth factor β (TGF-β) receptor on lung carcinogenesis
Lung Cancer, 2002Transforming growth factor beta (TGF-beta) type-II receptor mutations have been reported in several epithelial-type human malignancies. To elucidate the role of TGF-beta RII in lung cancer progression, we prepared gene-modified clones of the human lung cancer cell line NCI-H23.
Chaehwa, Park +4 more
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[Transforming growth factor-beta and its receptors].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1996Transforming growth factor-beta (TGF-beta) is a family of multifunctional proteins that inhibit the growth of most cell types, and these proteins induce the deposition of extracellular matrix. TGF-beta inhibits the growth and migration of endothelial cells in vitro, but induces angiogenesis in vivo. TGF-beta belongs to a larger superfamily known as the
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[Transforming growth factor-beta and its receptors in scleroderma].
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2010The hallmark of scleroderma is fibrosis by excessive extracellular matrix (ECM) deposition in the skin, lung, and other organs. Increasing evidence suggests that overexpression of transforming growth factor-beta (TGF-beta) and its receptors play a key pathogenic role in the development of tissue fibrosis in scleroderma.
Huan, QIAN, Min, ZHENG
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The American journal of pathology, 1997
Transforming growth factor (TGF)-beta has been implicated in the regulation of normal and neoplastic anterior pituitary cell function. TGF-beta regulates the expression of various proteins, including p27Kip1 (p27), a cell cycle inhibitory protein. We examined TGF-beta, TGF-beta type II receptor (TGF-beta-RII), and p27 expression in normal pituitaries ...
L, Jin +7 more
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Transforming growth factor (TGF)-beta has been implicated in the regulation of normal and neoplastic anterior pituitary cell function. TGF-beta regulates the expression of various proteins, including p27Kip1 (p27), a cell cycle inhibitory protein. We examined TGF-beta, TGF-beta type II receptor (TGF-beta-RII), and p27 expression in normal pituitaries ...
L, Jin +7 more
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