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Tumor necrosis factor receptor-2 (TNFR2): an overview of an emerging drug target
Expert opinion on therapeutic targets, 2019Introduction: Tumor necrosis factor (TNF) receptor 2 (TNFR2) is one of two receptors of the cytokines, TNF and lymphotoxin-α. TNFR1 is a strong inducer of proinflammatory activities.
Juliane Medler, H. Wajant
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Veterinary Immunology and Immunopathology, 2004
Tumor necrosis factor (TNF) receptor-associated factors (TRAFs) were identified as signal transducers for the tumor necrosis factor receptor (TNFR) superfamily. In this study, we cloned and characterized two genes that encode chicken TNFR-II and TRAF5.
Sayed Abdalla, Abdalla +3 more
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Tumor necrosis factor (TNF) receptor-associated factors (TRAFs) were identified as signal transducers for the tumor necrosis factor receptor (TNFR) superfamily. In this study, we cloned and characterized two genes that encode chicken TNFR-II and TRAF5.
Sayed Abdalla, Abdalla +3 more
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International Journal of Hematology, 2006
The interactions between members of the tumor necrosis factor (TNF) family and their specific receptors (TNFRs) are influential in controlling cell division, life, and death. Recent evidence suggests that these interactions control the functionality and longevity of many types of cells involved in immune responses.
Takanori, So +2 more
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The interactions between members of the tumor necrosis factor (TNF) family and their specific receptors (TNFRs) are influential in controlling cell division, life, and death. Recent evidence suggests that these interactions control the functionality and longevity of many types of cells involved in immune responses.
Takanori, So +2 more
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Immunobiology of Tumor Necrosis Factor Receptor Superfamily
Immunologic Research, 2002The proteins of the tumor necrosis factor (TNF) receptor superfamily are a group of cell-surface receptors critically involved in the maintenance of homeostasis of the immune system. By interacting with their corresponding ligands, these receptors either induce cell death or promote cell survival of immune cells. The number of recognized members of the
Tong, Zhou +2 more
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Assay of Soluble Tumor Necrosis Factor Receptors
2003Over the last decade, numerous basic biological as well as experimental and clinical studies have firmly established the significance of tumor necrosis factor (TNF) as a principal proximal mediator of sepsis (1-4). One of the major insights that has emerged during recent years has been that under physiological circumstances, TNF activity is tightly ...
Boumaand, M.G., Buurman, W.A.
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Tumor necrosis factor receptors-structure and function
Immunologic Research, 1992Tumor necrosis factors (TNFs) have been a focus of research for well over a decade now. The identification and recent molecular cloning of two different types of cell-surface TNF receptors will shed further light on the mode of action of these pleiotropic cytokines.
J, Rothe +3 more
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3D Modeling of Tumor Necrosis Factor Receptor and Tumor Necrosis Factor‐bound Receptor Systems
Molecular Informatics, 2019AbstractThe interactions between the tumor necrosis factor (TNF) and its receptor molecule are responsible for various signaling networks that are central to the functioning of human immune homeostasis. The present work is a computational study of certain structural aspects of this cell‐signaling protein, specifically focusing on the molecular level ...
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Tumor necrosis factor-? and tumor necrosis factor receptors in human heart failure
Heart Failure Reviews, 1996The basic mechanisms that are responsible for the development and progression of congestive heart failure are not known. Although clinicians have traditionally viewed heart failure as a hemodynamic disorder related to left ventricular pump dysfunction, one of the more recent concepts that has emerged is that the development and progression of heart ...
Biykem Bozkurt +4 more
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The Tumor Necrosis Factor Ligand and Receptor Families
New England Journal of Medicine, 1996Tumor necrosis factor (TNF) and lymphotoxin-α were isolated more than 10 years ago, on the basis of their ability to kill tumor cells in vitro and to cause hemorrhagic necrosis of transplantable tumors in mice.1 The complementary DNAs and genes encoding each protein were cloned immediately thereafter.2,3 Concurrently, a factor known as cachectin was ...
BAZZONI, Flavia, BEUTLER B.
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The nerve growth factor/tumor necrosis factor receptor family
Journal of Leukocyte Biology, 1996Abstract Receptors in the nerve growth factor/tumor necrosis factor receptor family are characterized by the presence of cysteine-rich motifs of ~40 amino acids in the extracellular domain. The ligands are type II transmembrane proteins with β-strands that form a jelly-roll β-sandwich.
Lotz, Martin +3 more
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