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Tumor necrosis factor family ligand–receptor binding
Current Opinion in Structural Biology, 2004Ligands and receptors of the tumor necrosis factor (TNF) superfamily have pivotal roles in the development and function of the immune system. The growing pool of data on TNF from structural and biochemical studies suggests that the higher order clustering of TNF family ligands could play an essential role in signal transduction initiation for this ...
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Tumor Necrosis Factor Receptors Encoded by Poxviruses
Molecular Genetics and Metabolism, 1999Poxviruses encode several cytokine response modifying (Crm) proteins. The Crm proteins possess sequence homology to several human proteins important in immunity. This homology and the conservation of Crm proteins among poxvirus strains suggest an immunomodulatory function that provides a survival advantage to the virus.
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Tumor necrosis factor receptor superfamily.
Journal of inflammation, 1997Tumor necrosis factor (TNF) is a powerful cytokine which is involved in the immune and pro-inflammatory response. The TNF receptors (TNF-R1 and TNF-R2) are the sole mediators of TNF signaling. The receptors consist of a disulfide rich domain which recognizes TNF, a transmembrane helix, and a cytoplasmic domain.
J H, Naismith, S R, Sprang
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The p70 tumor necrosis factor receptor mediates cytotoxicity
Cell, 1992Tumor necrosis factor alpha (TNF) selectively kills tumor cells, but this specificity is not clearly understood. Two distinctly different cell surface receptors (TNFRs), proteins of 55 kd (p55) and 70-80 kd (p70), mediate TNF action. Mouse TA1 cells are not killed by human (h) TNF, but are killed by mouse (m) TNF alone.
R A, Heller, K, Song, N, Fan, D J, Chang
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TUMOR NECROSIS FACTOR RECEPTOR AND Fas SIGNALING MECHANISMS
Annual Review of Immunology, 1999▪ Abstract Four members of the tumor necrosis factor (TNF) ligand family, TNF-α, LT-α, LT-β, and LIGHT, interact with four receptors of the TNF/nerve growth factor family, the p55 TNF receptor (CD120a), the p75 TNF receptor (CD120b), the lymphotoxin beta receptor (LTβR), and herpes virus entry mediator (HVEM) to control a wide range of innate and ...
D, Wallach +5 more
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Tumor necrosis factor receptors in the pituitary cells
Brain Research, 1997To clarify the site and mode of action of tumor necrosis factor (TNF) in the pituitary, we studied the effects, binding sites of TNF and its receptor mRNA in the two types of mouse pituitary-derived cell lines, AtT-20, ACTH-producing cells and TtT/GF, folliculo-stellate (FS)-like cells.
H, Kobayashi +9 more
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Tumor Necrosis Factor Ligand-Receptor Superfamily and Arthritis
2005The current studies of apoptosis in rheumatoid arthritis (RA) suggest that the TNF ligand-receptor superfamily (TNFRsF) molecules, downstream pathways (activation of proapoptosis or anti-apoptosis pathway), cell types (lymphocytes and synovial fibroblast), and the mechanism that triggers apoptosis (tolerance induction-related, downmodulation of ...
Hui-Chen, Hsu, Yalei, Wu, John D, Mountz
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Tumor necrosis factor: receptors and inhibitors.
Cancer cells (Cold Spring Harbor, N.Y. : 1989), 1991Tumor necrosis factor (TNF) is a highly potent pleiotropic response modifier in inflammatory and immunologic host defense reactions. It can also be toxic to cells and elicit toxic systemic reactions, as evinced by certain pathophysiologic conditions that are initiated or aggravated by an excess of TNF.
H, Loetscher, M, Steinmetz, W, Lesslauer
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Circulating tumor DNA in advanced solid tumors: Clinical relevance and future directions
Ca-A Cancer Journal for Clinicians, 2021Michael L Cheng +2 more
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