Results 261 to 270 of about 416,152 (310)

Tumor Necrosis Factor-α and Tumor Necrosis Factor Receptors in the Failing Human Heart

Circulation, 1996
Background Tumor necrosis factor-α (TNF-α) is a proinflammatory cytokine that produces negative inotropic effects in the heart. Recently, elevated levels of TNF-α have been reported in patients with advanced congestive heart failure.
G, Torre-Amione, S, Kapadia, J, Lee, J B, Durand, R D, Bies, J B, Young, D L, Mann   +6 more
openaire   +4 more sources

Molecular study on chicken tumor necrosis factor receptor-II and tumor necrosis factor receptor-associated factor-5

Veterinary Immunology and Immunopathology, 2004
Tumor necrosis factor (TNF) receptor-associated factors (TRAFs) were identified as signal transducers for the tumor necrosis factor receptor (TNFR) superfamily. In this study, we cloned and characterized two genes that encode chicken TNFR-II and TRAF5.
Sayed Abdalla, Abdalla, Hiroyuki, Horiuchi, Shuichi, Furusawa, Haruo, Matsuda   +3 more
openaire   +2 more sources

Tumor Necrosis Factor/Tumor Necrosis Factor Receptor Family Members That Positively Regulate Immunity

International Journal of Hematology, 2006
The interactions between members of the tumor necrosis factor (TNF) family and their specific receptors (TNFRs) are influential in controlling cell division, life, and death. Recent evidence suggests that these interactions control the functionality and longevity of many types of cells involved in immune responses.
Takanori, So, Seung-Woo, Lee, Michael, Croft   +2 more
openaire   +2 more sources

Immunobiology of Tumor Necrosis Factor Receptor Superfamily

Immunologic Research, 2002
The proteins of the tumor necrosis factor (TNF) receptor superfamily are a group of cell-surface receptors critically involved in the maintenance of homeostasis of the immune system. By interacting with their corresponding ligands, these receptors either induce cell death or promote cell survival of immune cells. The number of recognized members of the
Tong, Zhou, John D, Mountz, Robert P, Kimberly   +2 more
openaire   +2 more sources

Assay of Soluble Tumor Necrosis Factor Receptors

2003
Over the last decade, numerous basic biological as well as experimental and clinical studies have firmly established the significance of tumor necrosis factor (TNF) as a principal proximal mediator of sepsis (1-4). One of the major insights that has emerged during recent years has been that under physiological circumstances, TNF activity is tightly ...
Boumaand, M.G., Buurman, W.A.
openaire   +3 more sources

Tumor necrosis factor receptors-structure and function

Immunologic Research, 1992
Tumor necrosis factors (TNFs) have been a focus of research for well over a decade now. The identification and recent molecular cloning of two different types of cell-surface TNF receptors will shed further light on the mode of action of these pleiotropic cytokines.
J, Rothe, G, Gehr, H, Loetscher, W, Lesslauer   +3 more
openaire   +2 more sources

3D Modeling of Tumor Necrosis Factor Receptor and Tumor Necrosis Factor‐bound Receptor Systems

Molecular Informatics, 2019
AbstractThe interactions between the tumor necrosis factor (TNF) and its receptor molecule are responsible for various signaling networks that are central to the functioning of human immune homeostasis. The present work is a computational study of certain structural aspects of this cell‐signaling protein, specifically focusing on the molecular level ...
openaire   +2 more sources

Signal transduction by tumor necrosis factor receptors

Cellular Signalling, 2012
Tumor necrosis factor (TNF) is a key mediator in the inflammatory response which is implicated in the onset of a number of diseases. Research on TNF led to the characterization of the largest family of cytokines known until now, the TNF superfamily, which exert their biological effects through the interaction with transmembrane receptors of the TNFR ...
Lucía, Cabal-Hierro, Pedro S, Lazo
openaire   +2 more sources

Tumor necrosis factor-? and tumor necrosis factor receptors in human heart failure

Heart Failure Reviews, 1996
The basic mechanisms that are responsible for the development and progression of congestive heart failure are not known. Although clinicians have traditionally viewed heart failure as a hemodynamic disorder related to left ventricular pump dysfunction, one of the more recent concepts that has emerged is that the development and progression of heart ...
Biykem Bozkurt, Kesavan Shan, Yukihiro Seta, Hakan Oral, Douglas L. Mann   +4 more
openaire   +1 more source

The nerve growth factor/tumor necrosis factor receptor family

Journal of Leukocyte Biology, 1996
Abstract Receptors in the nerve growth factor/tumor necrosis factor receptor family are characterized by the presence of cysteine-rich motifs of ~40 amino acids in the extracellular domain. The ligands are type II transmembrane proteins with β-strands that form a jelly-roll β-sandwich.
Lotz, Martin, Setareh, Morey, Kempis, Johannes von, Schwarz, Herbert   +3 more
openaire   +3 more sources