Results 51 to 60 of about 738,282 (345)

Novel anti-tumour necrosis factor receptor-1 (TNFR1) domain antibody prevents pulmonary inflammation in experimental acute lung injury. [PDF]

, 2018
BACKGROUND: Tumour necrosis factor alpha (TNF-α) is a pleiotropic cytokine with both injurious and protective functions, which are thought to diverge at the level of its two cell surface receptors, TNFR1 and TNFR2.

core   +2 more sources

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

The rs11684747 and rs55790676 SNPs of ADAM17 influence tuberculosis susceptibility and plasma levels of TNF, TNFR1, and TNFR2

Frontiers in Microbiology
IntroductionThe proteolytic activity of A Disintegrin and Metalloproteinase 17 (ADAM17) regulates the release of tumor necrosis factor (TNF) and TNF receptors (TNFRs) from cell surfaces.
José Alberto Choreño-Parra, José Alberto Choreño-Parra, Lucero A. Ramon-Luing, Manuel Castillejos, Emmanuel Ortega-Martínez, Emmanuel Ortega-Martínez, Emmanuel Ortega-Martínez, Alan Rodrigo Tapia-García, Alan Rodrigo Tapia-García, Melvin Barish Matías-Martínez, Melvin Barish Matías-Martínez, Alfredo Cruz-Lagunas, Gustavo Ramírez-Martínez, Itzel Alejandra Gómez-García, Itzel Alejandra Gómez-García, Jazmín Ariadna Ramírez-Noyola, Jazmín Ariadna Ramírez-Noyola, Beatriz Garcia-Padrón, Beatriz Garcia-Padrón, Karen Gabriel López-Salinas, Karen Gabriel López-Salinas, Fabiola Jiménez-Juárez, Fabiola Jiménez-Juárez, Parménides Guadarrama-Ortiz, Citlaltepetl Salinas-Lara, Citlaltepetl Salinas-Lara, Karolina Bozena-Piekarska, Marcela Muñóz-Torrico, Leslie Chávez-Galán, Joaquín Zúñiga, Joaquín Zúñiga   +30 more
doaj   +1 more source

Peptidoglycan and Bacterial DNA Induce Inflammation and Coagulation Markers in Synergy

Mediators of Inflammation, 2005
Bacterial compounds signal the presence of foreign pathogens in the innate immune system. These microbial components are key players in infectious diseases and implicate toll-like receptors in the activation of inflammation and coagulation. Nevertheless,
Marie-Claude Amoureux, Nandani Rajapakse, Lazlo Stipkovits, Susan Szathmary   +3 more
doaj   +1 more source

Prognostic significance of TRAIL-R3 and CCR-2 expression in tumor epithelial cells of patients with early breast cancer [PDF]

, 2017
Tumor epithelial cells (TEpCs) and spindle-shaped stromal cells, not associated with the vasculature, of patients with early breast cancer express osteoprotegerin (OPG), tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), receptor activator ...
Borzone, Francisco Raúl, Chasseing, Norma Alejandra, Choi, Hosoon, Davies, Kevin Mauro, de Luján Calcagno, María, Feldman, Leonardo, García Rivello, Hernán, Giorello, María Belén, Howard, Scott C., Labovsky, Vivian, Martinez, Leandro Marcelo, Matas, Ayelen, Wernicke, Alejandra   +12 more
core   +2 more sources

Tumor Necrosis Factor Induces Tumor Necrosis via Tumor Necrosis Factor Receptor Type 1-Expressing Endothelial Cells of the Tumor Vasculature [PDF]

The American Journal of Pathology, 2000
Activation of endothelial cells, fibrin deposition, and coagulation within the tumor vasculature has been shown in vivo to correlate with the occurrence of tumor necrosis factor (TNF)-induced tumor necrosis in mice. In the present study we investigated which target cells mediate the TNF-induced necrosis in fibrosarcomas grown in wild type (wt), TNF ...
B, Stoelcker, B, Ruhland, T, Hehlgans, H, Bluethmann, T, Luther, D N, Männel   +5 more
openaire   +2 more sources

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Targeting of Tumor Necrosis Factor Alpha Receptors as a Therapeutic Strategy for Neurodegenerative Disorders

Antibodies, 2015
Numerous studies have revealed the pleiotropic functions of tumor necrosis factor alpha (TNF-α), and have linked it with several neurodegenerative disorders.
Yun Dong, Doortje W. Dekens, Peter Paul De Deyn, Petrus J. W. Naudé, Ulrich L. M. Eisel   +4 more
doaj   +1 more source

β2-adrenergic agonists modulate TNF-α induced astrocytic inflammatory gene expression and brain inflammatory cell populations [PDF]

, 2014
Background: The NF-kappa B signaling pathway orchestrates many of the intricate aspects of neuroinflammation. Astrocytic beta(2)-adrenergic receptors have emerged as potential regulators in central nervous system inflammation and are potential targets ...
Aerts, Joeri L, De Keyser, Jacques, Demol, Frauke, Gerlo, Sarah, Laureys, Guy, Spooren, Anneleen   +5 more
core   +3 more sources

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source