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Inhibitors of Vascular Endothelial Growth Factor Receptor
2017Angiogenesis-targeting agents, predominantly inhibitors of vascular endothelial growth factor and its receptors, have become a mainstay in oncology practice over the last decade. The approved drugs, which include two antibodies and seven small molecule inhibitors, represent strong validation for the field of anti-angiogenesis in the treatment of cancer.
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A receptor for vascular endothelial growth factor that stimulates endothelial apoptosis.
Cancer research, 2002Vascular endothelial growth factor (VEGF) is a dimeric angiogenic factor that is overexpressed by many tumors and stimulates tumor angiogenesis. VEGF initiates signaling by dimerizing the receptors VEGFR-1 and VEGFR-2. The Fas receptor stimulates apoptosis, and artificial dimerization of the Fas cytoplasmic domain has been shown to induce apoptosis. We
T P, Quinn +4 more
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Vascular endothelial growth factors and angiogenesis in eye disease
Progress in Retinal and Eye Research, 2003G F J M Vrensen +2 more
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Vascular-endothelial-growth-factor-receptor-antagonists
Reactions Weekly, 2022openaire +1 more source
Distinct vascular endothelial growth factor signals for lymphatic vessel enlargement and sprouting
Journal of Experimental Medicine, 2007Seppo Ylä-Herttuala +2 more
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