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Inhibitors of Vascular Endothelial Growth Factor Receptor

2017
Angiogenesis-targeting agents, predominantly inhibitors of vascular endothelial growth factor and its receptors, have become a mainstay in oncology practice over the last decade. The approved drugs, which include two antibodies and seven small molecule inhibitors, represent strong validation for the field of anti-angiogenesis in the treatment of cancer.
openaire   +1 more source

A receptor for vascular endothelial growth factor that stimulates endothelial apoptosis.

Cancer research, 2002
Vascular endothelial growth factor (VEGF) is a dimeric angiogenic factor that is overexpressed by many tumors and stimulates tumor angiogenesis. VEGF initiates signaling by dimerizing the receptors VEGFR-1 and VEGFR-2. The Fas receptor stimulates apoptosis, and artificial dimerization of the Fas cytoplasmic domain has been shown to induce apoptosis. We
T P, Quinn   +4 more
openaire   +1 more source

Vascular Endothelial Growth Factors and Receptors

2010
Anna Dimberg   +3 more
openaire   +1 more source

Vascular endothelial growth factors and angiogenesis in eye disease

Progress in Retinal and Eye Research, 2003
G F J M Vrensen   +2 more
exaly  

Distinct vascular endothelial growth factor signals for lymphatic vessel enlargement and sprouting

Journal of Experimental Medicine, 2007
Seppo Ylä-Herttuala   +2 more
exaly  

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