Results 21 to 30 of about 201,272 (268)

Pigment Epithelial‐Derived Factor Deficiency Accelerates Atherosclerosis Development via Promoting Endothelial Fatty Acid Uptake in Mice With Hyperlipidemia

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Endothelial cell injury, induced by dyslipidemia, is the initiation of atherosclerosis, resulting in an imbalance in endothelial fatty acid (FA) transport. Pigment epithelial‐derived factor (PEDF) is an important regulator in lipid metabolism.
Haiping Wang, Yanfang Yang, Ming Yang, Xinghui Li, Jing Tan, Yandi Wu, Yuling Zhang, Yuanlong Li, Bo Hu, Shijie Deng, Fengmin Yang, Saifei Gao, Hui Li, Zhenyu Yang, Hui Chen, Weibin Cai   +15 more
doaj   +1 more source

Human Herpesvirus-8-Transformed Endothelial Cells Have Functionally Activated Vascular Endothelial Growth Factor/Vascular Endothelial Growth Factor Receptor [PDF]

The American Journal of Pathology, 2002
Kaposi's sarcoma is a vascular tumor commonly associated with human immunodeficiency virus (HIV)-1 and human herpesvirus (HHV-8) also known as Kaposi's sarcoma-associated herpesvirus. The principal features of this tumor are abnormal proliferation of vascular structures lined with spindle-shaped endothelial cells. HHV-8 may transform a subpopulation of
Rizwan, Masood, Ethel, Cesarman, D Lynne, Smith, Parkash S, Gill, Ornella, Flore   +4 more
openaire   +2 more sources

Proliferative effects of metamizole sodium on U-87 MG glioblastoma cell line: a pain killer or a killer? [PDF]

World Cancer Research Journal, 2021
OBJECTIVE: During cancer treatment, painkillers are often used to alleviate patient pain. Metamizole is a pyrazolone derivative and a non-opioid pain reliever.
O. Koçak, E. Şimşek
doaj   +1 more source

Influence of hypoxia and neoangiogenesis on the growth of pancreatic cancer

Molecular Cancer, 2003
As with other solid tumors, the growth and metastasis of pancreatic cancer is critically dependent on tumor angiogenesis. A major stimulus for a tumor's recruitment of additional blood vessels is cellular hypoxia, a condition which is especially ...
Reber Howard A, Eibl Guido, Duffy John P, Hines Oscar J   +3 more
doaj   +1 more source

Anlotinib: A Novel Targeted Drug for Bone and Soft Tissue Sarcoma

Frontiers in Oncology, 2021
Bone and soft tissue sarcomas account for approximately 15% of pediatric solid malignant tumors and 1% of adult solid malignant tumors. There are over 50 subtypes of sarcomas, each of which is notably heterogeneous and manifested by remarkable phenotypic
Shenglong Li, Shenglong Li
doaj   +1 more source

Serum vascular endothelial growth factor levels and tumor molecular marker expression in patients with secondary-edematous breast cancer during treatment dynamics

Journal of V. N. Karazin Kharkiv National University: Series Medicine
Background. Secondary-edematous breast cancer is characterized by high aggressiveness and a lack of clear prognostic markers. Studying the role of Vascular Endothelial Growth Factor in relation to the expression of steroid hormone receptors, HER2/neu ...
O.M. Bilyі, N.A. Mitrіaіeva, L.V. Grebinyk, O.V. Slobodianiuk, S.O. Pylypenko   +4 more
doaj   +1 more source

Activity of cabozantinib in radioresistant brain metastases from renal cell carcinoma: two case reports

Journal of Medical Case Reports, 2018
Background Renal cell carcinoma represents 3–5% of adult malignant tumors. Metastases are found in 30–40% of patients and brain metastases occurred in more than 10% of them.
Sylvie Négrier, Guillaume Moriceau, Valéry Attignon, Véronique Haddad, Daniel Pissaloux, Nicole Guerin, Christian Carrie   +6 more
doaj   +1 more source

Abl family kinases regulate endothelial barrier function in vitro and in mice. [PDF]

PLoS ONE, 2013
The maintenance of endothelial barrier function is essential for normal physiology, and increased vascular permeability is a feature of a wide variety of pathological conditions, leading to complications including edema and tissue damage.
Elizabeth M Chislock, Ann Marie Pendergast   +1 more
doaj   +1 more source

Anti-angiogenic and antioxidant effects of axitinib in human retinal endothelial cells: implications in diabetic retinopathy

Frontiers in Pharmacology
Diabetic retinopathy is a secondary microvascular complication of diabetes mellitus. This disease progresses from two stages, non-proliferative and proliferative diabetic retinopathy, the latter characterized by retinal abnormal angiogenesis ...
Francesca Lazzara, Federica Conti, Pradip K. Sasmal, Shanavas Alikunju, Settimio Rossi, Filippo Drago, Filippo Drago, Chiara Bianca Maria Platania, Chiara Bianca Maria Platania, Claudio Bucolo, Claudio Bucolo   +10 more
doaj   +1 more source

Factors of angiogenesis in the development of physiological and pathological processes of the female gonads

Бюллетень сибирской медицины, 2016
The literature review focuses on the role of various growth factors in the developing vasculature of the ovary. Vascularization plays an important role in physiological processes such as development and atresia of a follicle, the formation of the yellow ...
V. G. Zenkina
doaj   +1 more source