Results 111 to 120 of about 4,110,019 (315)

Evolving Intelligent Reflector Surface towards 6G for Public Health: Application in Airborne Virus Detection [PDF]

arXiv, 2020
While metasurface based intelligent reflecting surfaces (IRS) are an important emerging technology for future generations of wireless connectivity in its own right, the plans for the mass deployment of these surfaces motivate the question of their integration with other new and emerging technologies that would require mass proliferation.
arxiv  

Plant immunity against viruses: antiviral immune receptors in focus

Annals of Botany, 2016
Background Among the environmental limitations that affect plant growth, viruses cause major crop losses worldwide and represent serious threats to food security.
I. P. Calil, E. Fontes
semanticscholar   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Mathematical model of SARS-Cov-2 propagation versus ACE2 fits COVID-19 lethality across age and sex and predicts that of SARS, supporting possible therapy [PDF]

arXiv, 2020
The fatality rate of Covid-19 escalates with age and is larger in men than women. I show that these variations correlate strongly with the level of the viral receptor protein ACE2 in rat lungs, which is consistent with the still limited and apparently contradictory data on human ACE2.
arxiv  

The Interplay between the Host Receptor and Influenza Virus Hemagglutinin and Neuraminidase

International Journal of Molecular Sciences, 2017
The hemagglutinin (HA) and neuraminidase (NA) glycoproteins of influenza A virus are responsible for the surface interactions of the virion with the host.
Lauren Byrd-Leotis, R. Cummings, D. Steinhauer   +2 more
semanticscholar   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

SARS-CoV-2 mortality in blacks and temperature-sensitivity to an angiotensin-2 receptor blocker [PDF]

arXiv, 2020
Tropical climates provoke adaptations in skin pigmentation and in mechanisms controlling the volume, salt-content and pressure of body fluids. For many whose distant ancestors moved to temperate climes, these adaptations proved harmful: pigmentation decreased by natural selection and susceptibility to hypertension emerged.
arxiv  

Virus Infection and Death Receptor-Mediated Apoptosis

Viruses, 2017
Virus infection can trigger extrinsic apoptosis. Cell-surface death receptors of the tumor necrosis factor family mediate this process. They either assist persistent viral infection or elicit the elimination of infected cells by the host.
Xingchen Zhou, Wenbo Jiang, Zhongshun Liu, Shuai Liu, Xiaozhen Liang   +4 more
semanticscholar   +1 more source

Microglial reprogramming: a potential new frontier in enhancing immunotherapy for melanoma brain metastasis

Molecular Oncology, EarlyView.
Microglia act as tumor suppressors during brain metastasis colonization but shift to a tumor‐promoting role after melanoma brain metastases form. NF‐κB/RelA signaling emerges as a key driver of this phenotypic shift. Targeting this pathway reprograms microglia into a pro‐inflammatory state, enhancing antitumor immunity and immune checkpoint inhibitor ...
Noam Savion‐Gaiger, Dorin Bar‐Ziv, Harriet Kluger   +2 more
wiley   +1 more source

The virus–receptor interaction in the replication of feline immunodeficiency virus (FIV)

Current Opinion in Virology, 2013
The feline and human immunodeficiency viruses (FIV and HIV) target helper T cells selectively, and in doing so they induce a profound immune dysfunction. The primary determinant of HIV cell tropism is the expression pattern of the primary viral receptor CD4 and co-receptor(s), such as CXCR4 and CCR5.
Brian J. Willett, Margaret J Hosie
openaire   +3 more sources