Results 61 to 70 of about 608,655 (310)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Flavivirus Entry Receptors: An Update

Viruses, 2013
Flaviviruses enter host cells by endocytosis initiated when the virus particles interact with cell surface receptors. The current model suggests that flaviviruses use at least two different sets of molecules for infectious entry: attachment factors that ...
Manuel Perera-Lecoin, Laurent Meertens, Xavier Carnec, Ali Amara   +3 more
doaj   +1 more source

The role of cellular adhesion molecules in virus attachment and entry [PDF]

, 2015
As obligate intracellular parasites, viruses must traverse the host-cell plasma membrane to initiate infection. This presents a formidable barrier, which they have evolved diverse strategies to overcome.
Bhella, David
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Receptor specificity and transmission of H2N2 subtype viruses isolated from the pandemic of 1957. [PDF]

PLoS ONE, 2010
Influenza viruses of the H2N2 subtype have not circulated among humans in over 40 years. The occasional isolation of avian H2 strains from swine and avian species coupled with waning population immunity to H2 hemagglutinin (HA) warrants investigation of ...
Claudia Pappas, Karthik Viswanathan, Aarthi Chandrasekaran, Rahul Raman, Jacqueline M Katz, Ram Sasisekharan, Terrence M Tumpey   +6 more
doaj   +1 more source

Human metapneumovirus: Mechanisms and molecular targets used by the virus to avoid the immune system [PDF]

, 2018
Indexación: Scopus.This work was supported by Comisión Nacional de Investigación Científica y Tecnolígica (CONICYT) N◦21151028 and FONDECYT (N◦1070352 and N◦1170964) and the Millennium Institute on Immunology and Immunotherapy (P09/016-F).Human ...
Benavente, F.M., Bueno, S.M., Gonzalez, P.A., Gálvez, N.M.S., Kalergis, A.M., Lay, M.K., Pizarro-Ortega, M.S., Riedel, C., Soto, J.A.   +8 more
core   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Cellular receptors for mammalian viruses.

PLoS Pathogens
The interaction of viral surface components with cellular receptors and other entry factors determines key features of viral infection such as host range, tropism and virulence.
Ana Valero-Rello, Carlos Baeza-Delgado, Iván Andreu-Moreno, Rafael Sanjuán   +3 more
doaj   +1 more source

Identification of novel subgroup a variants with enhanced receptor binding and replicative capacity in primary isolates of anaemogenic strains of feline leukaemia virus [PDF]

, 2012
<b>BACKGROUND:</b> The development of anaemia in feline leukaemia virus (FeLV)-infected cats is associated with the emergence of a novel viral subgroup, FeLV-C.
A Manrique, AJ Phipps, AS McDougall, Brian J Willett, C Chandhasin, C Munk, CP Geret, CS Tailor, D Onions, EA Hoover, Elizabeth L McMonagle, ES Svarovskaia, FL Graham, G Towers, GA Dean, H Chen, Hazel Stewart, J Brojatsch, J Hartikka, JG Quigley, JG Quigley, JI Mullins, JK Brown, Karen W Adema, KS Levesque, L Mackey, LL Bolin, M Gouy, M Reinacher, MA Rey, MA Rigby, MA Stewart, Margaret J Hosie, MM Anderson, N Hussain, N Riedel, N Riedel, NC Pedersen, O Jarrett, O Jarrett, O Jarrett, O Jarrett, O Jarrett, O Jarrett, OB Spiller, PH Russell, PM Rwambo, PR Donahue, PS Sarma, R Mendoza, R Pandey, RL Sheets, S Boomer, S Nakowitsch, T Ohashi, WD Hardy, WD Hardy, WD Hardy, Z Shalev   +58 more
core   +3 more sources

Specificity switching in virus–receptor complexes [PDF]

Current Opinion in Structural Biology, 2009
Several structures of complexes between viral attachment proteins and their cellular receptors have been determined recently, enhancing our understanding of the molecular recognition processes that guide formation of virus-receptor complexes. Moreover, these structures also highlight strategies by which highly similar viral proteins within a single ...
Stehle, Thilo, Casasnovas, José M
openaire   +2 more sources