Results 21 to 30 of about 5,911,760 (307)

Deciphering the Molecular Interaction Between the Adhesion G Protein-Coupled Receptor ADGRV1 and its PDZ-Containing Regulator PDZD7

Frontiers in Molecular Biosciences, 2022
Hearing relies on the transduction of sound-evoked vibrations into electrical signals, occurring in the stereocilia bundle of inner ear hair cells. The G protein-coupled receptor (GPCR) ADGRV1 and the multi-PDZ protein PDZD7 play a critical role in the ...
Baptiste Colcombet-Cazenave, Baptiste Colcombet-Cazenave, Florence Cordier, Florence Cordier, Yanlei Zhu, Guillaume Bouvier, Eleni Litsardaki, Louise Laserre, Marie S. Prevost, Bertrand Raynal, Célia Caillet-Saguy, Nicolas Wolff   +11 more
doaj   +1 more source

NUCLEAR RECEPTORS [PDF]

British Journal of Pharmacology, 2007
ALEXANDER, S.P.H., MATHIE, A. & PETERS, J.A. (2007). Guide to Receptors and Channels (GRAC), 2nd edition (2007 revision). Br. J. Pharmacol., 150 (Suppl. 1), S1–S168.
John A. Peters, S P H Alexander, Alistair Mathie   +2 more
openaire   +4 more sources

P2X receptor trafficking in neurons is subunit specific [PDF]

, 2002
P2X receptors within the CNS mediate excitatory synaptic transmission and also act presynaptically to modulate neurotransmitter release. We have studied the targeting and trafficking of P2X4 and P2X2 receptors heterologously expressed in cultured ...
Bobanovic, Laura K, Murrell-Lagnado, Ruth D, Royle, Stephen J   +2 more
core   +3 more sources

RNase P-Associated External Guide Sequences Inhibit HIV-1 Infection by Shutting Down Human CCR5 Expression

Receptors
Background: External guide sequences (EGSs) are small RNA molecules capable of hybridizing to a target mRNA and rendering the target RNA susceptible to degradation by ribonuclease P (RNase P), a tRNA processing enzyme.
Yujun Liu, Bin Yan, Isadora Zhang, Fenyong Liu   +3 more
doaj   +1 more source

The desensitization pathway of GABAA receptors, one subunit at a time

Nature Communications, 2020
GABAA receptors mediate most inhibitory synaptic transmission in the brain. Here authors used concatemeric α1β2γ2 GABAA receptors to introduce gain-of-desensitization mutations one subunit at a time, revealing non-concerted rearrangements with a key ...
Marc Gielen, Nathalie Barilone, Pierre-Jean Corringer   +2 more
doaj   +1 more source

Liver X Receptor Regulation of Glial Cell Functions in the CNS

Biomedicines, 2022
In this review, we discuss the role of liver X receptors (LXRs) in glial cells (microglia, oligodendrocytes and astrocytes) in the central nervous system (CNS).
Xiaoyu Song, Wanfu Wu, Margaret Warner, Jan-Åke Gustafsson   +3 more
doaj   +1 more source

Synthesis, biological evaluation, and SAR studies of 14β-phenylacetyl substituted 17-cyclopropylmethyl-7, 8-dihydronoroxymorphinones derivatives : Ligands with mixed NOP and opioid receptor profile [PDF]

, 2018
© 2018 Kumar, Polgar, Cami-Kobeci, Thomas, Khroyan, Toll and Husbands.A series of 14β-acyl substituted 17-cyclopropylmethyl-7,8-dihydronoroxymorphinone compounds has been synthesized and evaluated for affinity and efficacy for mu (MOP), kappa (KOP), and ...
Cami-Kobeci, Champion, Cheng, Christoph, Ding, Dooley, Greedy, Greiner, Gumusel, Günther, Hu, Huang, Jenck, Khroyan, Khroyan, Kiguchi, Ko, Lewis, Lewis, Lia, Manabe, Meunier, Meunier, Mogil, Mollereau, Moynihan, Pomonis, Raffa, Reinsceid, Rizzi, Rossi, Saccone, Sandin, Schmidhammer, Schmidhammer, Schmidhammer, Spagnolo, Sukhtankar, Thompson, Toll, Toll, Traynor, Ueda, Vanderah, Váradi, Woodcock, Yu, Zeilhofer   +47 more
core   +2 more sources

The insulin receptor [PDF]

The Journal of Pediatrics, 1981
Cells are endowed with specific cognitive molecules that function as receptors for hormones, neurotransmitters, and other intercellular messengers. The receptor molecules may be present in the plasma membrane, cytoplasm, or nucleus. When occupied by the messenger, the receptor is coupled to the cellular machinery that responds to the message-bearing ...
openaire   +4 more sources

Adenosine A1 receptor: Functional receptor-receptor interactions in the brain [PDF]

Purinergic Signalling, 2007
Over the past decade, many lines of investigation have shown that receptor-mediated signaling exhibits greater diversity than previously appreciated. Signal diversity arises from numerous factors, which include the formation of receptor dimers and interplay between different receptors.
Kathrin Sichardt, Karen Nieber
openaire   +3 more sources

LPA₃: Pharmacodynamic Differences Between Lysophosphatidic Acid and Oleoyl-Methoxy Glycerophosphothionate: Biased Agonism, Two Sites

Receptors
Background: Lysophosphatidic acid (LPA) receptor 3 (LPA3) is involved in many physiological and pathophysiological actions of this bioactive lipid, particularly in cancer.
K. Helivier Solís, M. Teresa Romero-Ávila, Ruth Rincón-Heredia, Juan Carlos Martínez-Morales, J. Adolfo García-Sáinz   +4 more
doaj   +1 more source