Results 41 to 50 of about 3,677,585 (337)

Exploring the Role of GLP-1 Receptor Agonists in Alzheimer’s Disease: A Review of Preclinical and Clinical Evidence

Receptors
Glucagon-like peptide-1 receptor agonists (GLP-1RAs), including dulaglutide, liraglutide, semaglutide, and exenatide, are effective treatments for type 2 diabetes mellitus (T2DM) and obesity.
Lívia C. R. Teixeira, Marcelo R. Luizon, Karina B. Gomes   +2 more
doaj   +1 more source

Constitutively active androgen receptor supports the metastatic phenotype of endocrine-resistant hormone receptor-positive breast cancer

Cell Communication and Signaling, 2020
Background Hormone receptor positive (HR+) breast cancer (BCa) is the most frequently diagnosed subtype. Acquired and intrinsic resistance to conventional endocrine therapy (ET) commonly occurs and prompts incurable metastatic disease.
Shaymaa Bahnassy, Hariprasad Thangavel, Maram Quttina, Ashfia Fatima Khan, Dhanya Dhanyalayam, Joan Ritho, Samaneh Karami, Jing Ren, Tasneem Bawa-Khalfe   +8 more
doaj   +1 more source

Mutational analysis to explore long-range allosteric couplings involved in a pentameric channel receptor pre-activation and activation

eLife, 2021
Pentameric ligand-gated ion channels (pLGICs) mediate chemical signaling through a succession of allosteric transitions that are yet not completely understood as intermediate states remain poorly characterized by structural approaches.
Solène N Lefebvre, Antoine Taly, Anaïs Menny, Karima Medjebeur, Pierre-Jean Corringer   +4 more
doaj   +1 more source

Melatonin receptor expression in the zebra finch brain and peripheral tissues [PDF]

, 2012
The circadian endocrine hormone melatonin plays a significant role in many physiological processes such as modulating sleep/wake cycle and oxidative stress.
Brandstaetter, Roland, Helfer, Gisela, Jones, Catherine   +2 more
core   +1 more source

Infection Models for Pine Wilt Disease on the Basis of Vector Behaviors

Population Ecology, EarlyView.
Infection models for pine wilt disease without vector density were built to estimate the transmission coefficient of the pathogenic nematode. The models successfully simulated the annual change in the density of infected trees for four pine stands. ABSTRACT Pine wilt disease is caused by the pinewood nematode (Bursaphelenchus xylophilus Steiner et ...
Katsumi Togashi
wiley   +1 more source

Machine Learning Classification of 3D Intracellular Trafficking Using Custom and Imaris-Derived Motion Features

Receptors
Background: Detecting intracellular diffusion dynamics with high spatiotemporal resolution is critical for understanding the complex molecular mechanisms that govern viral infection, drug delivery, and sustained receptor signaling within cellular ...
Oleg Kovtun
doaj   +1 more source

Origin and diversification of steroids: Co-evolution of enzymes and nuclear receptors [PDF]

, 2010
Recent sequencing of amphioxus and sea urchin genomes has provided important data for understanding the origins of enzymes that synthesize adrenal and sex steroids and the receptors that mediate physiological response to these vertebrate steroids ...
Michael E. Baker
core   +1 more source

Conditional gene deletion reveals functional redundancy of GABAB receptors in peripheral nociceptors in vivo [PDF]

, 2009
Background Gamma-aminobutyric acid (GABA) is an important inhibitory neurotransmitter which mainly mediates its effects on neurons via ionotropic (GABAA) and metabotropic (GABAB) receptors.
Bernhard Bettler, Dirig DM, Hao JX, Hosny A, Imgard Tegeder, Martina Kurejova, Nitin Agarwal, Rohini Kuner, Stefan Brugger, Vijayan Gangadharan   +9 more
core   +3 more sources

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

Bioelectric Membrane Potential and Breast Cancer: Advances in Neuroreceptor Pharmacology for Targeted Therapeutic Strategies

Receptors
Bioelectric membrane potentials regulate cellular growth, differentiation, and movement. Disruptions in bioelectric signaling are strongly linked to cancer development, as abnormal membrane potentials and ion channel activity can drive tumor progression.
Chitaranjan Mahapatra, Jineetkumar Gawad, Chandrakant Bonde, Mahesh B. Palkar   +3 more
doaj   +1 more source