Results 41 to 50 of about 5,911,760 (307)

Stabilin Receptors: Role as Phosphatidylserine Receptors [PDF]

Biomolecules, 2019
Phosphatidylserine is a membrane phospholipid that is localized to the inner leaflet of the plasma membrane. Phosphatidylserine externalization to the outer leaflet of the plasma membrane is an important signal for various physiological processes, including apoptosis, platelet activation, cell fusion, lymphocyte activation, and regenerative axonal ...
Seung-Yoon Park, In-San Kim
openaire   +4 more sources

Exploring the Role of GLP-1 Receptor Agonists in Alzheimer’s Disease: A Review of Preclinical and Clinical Evidence

Receptors
Glucagon-like peptide-1 receptor agonists (GLP-1RAs), including dulaglutide, liraglutide, semaglutide, and exenatide, are effective treatments for type 2 diabetes mellitus (T2DM) and obesity.
Lívia C. R. Teixeira, Marcelo R. Luizon, Karina B. Gomes   +2 more
doaj   +1 more source

Constitutively active androgen receptor supports the metastatic phenotype of endocrine-resistant hormone receptor-positive breast cancer

Cell Communication and Signaling, 2020
Background Hormone receptor positive (HR+) breast cancer (BCa) is the most frequently diagnosed subtype. Acquired and intrinsic resistance to conventional endocrine therapy (ET) commonly occurs and prompts incurable metastatic disease.
Shaymaa Bahnassy, Hariprasad Thangavel, Maram Quttina, Ashfia Fatima Khan, Dhanya Dhanyalayam, Joan Ritho, Samaneh Karami, Jing Ren, Tasneem Bawa-Khalfe   +8 more
doaj   +1 more source

Mutational analysis to explore long-range allosteric couplings involved in a pentameric channel receptor pre-activation and activation

eLife, 2021
Pentameric ligand-gated ion channels (pLGICs) mediate chemical signaling through a succession of allosteric transitions that are yet not completely understood as intermediate states remain poorly characterized by structural approaches.
Solène N Lefebvre, Antoine Taly, Anaïs Menny, Karima Medjebeur, Pierre-Jean Corringer   +4 more
doaj   +1 more source

Machine Learning Classification of 3D Intracellular Trafficking Using Custom and Imaris-Derived Motion Features

Receptors
Background: Detecting intracellular diffusion dynamics with high spatiotemporal resolution is critical for understanding the complex molecular mechanisms that govern viral infection, drug delivery, and sustained receptor signaling within cellular ...
Oleg Kovtun
doaj   +1 more source

Physiopathological Implications of 7TM Receptors [PDF]

, 2010
Seven-transmembrane (7TM) receptors are one of the most important proteins involved in perception of extracellular stimuli and regulation of variety of intracellular signaling pathways.
Cygankiewicz, Adam
core   +1 more source

Bioelectric Membrane Potential and Breast Cancer: Advances in Neuroreceptor Pharmacology for Targeted Therapeutic Strategies

Receptors
Bioelectric membrane potentials regulate cellular growth, differentiation, and movement. Disruptions in bioelectric signaling are strongly linked to cancer development, as abnormal membrane potentials and ion channel activity can drive tumor progression.
Chitaranjan Mahapatra, Jineetkumar Gawad, Chandrakant Bonde, Mahesh B. Palkar   +3 more
doaj   +1 more source

Diagnostic and therapeutic strategies for non-alcoholic fatty liver disease

Frontiers in Pharmacology, 2022
The global incidence rate of non-alcoholic fatty liver disease (NAFLD) is approximately 25%. With the global increase in obesity and its associated metabolic syndromes, NAFLD has become an important cause of chronic liver disease in many countries ...
Yajie Fu, Yanzhi Zhou, Linhu Shen, Xuewen Li, Haorui Zhang, Yeqi Cui, Ke Zhang, Weiguo Li, Wei-dong Chen, Wei-dong Chen, Shizhen Zhao, Yunfu Li, Wenling Ye   +12 more
doaj   +1 more source

Single channel study of the spasmodic mutation α1A52S in recombinant rat glycine receptors [PDF]

, 2007
Inherited defects in glycine receptors lead to hyperekplexia, or startle disease. A mutant mouse, spasmodic, that has a startle phenotype, has a point mutation (A52S) in the glycine receptor α1 subunit.
Colquhoun, D., Groot-Kormelink, P., Plested, A.J.R., Sivilotti, L.G.   +3 more
core   +2 more sources

Bioinformatics and mathematical modelling in the study of receptor–receptor interactions and receptor oligomerization

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2011
The concept of intra-membrane receptor-receptor interactions (RRIs) between different types of G protein-coupled receptors (GPCRs) and evidence for their existence was introduced by Agnati and Fuxe in 1980/81 through the biochemical analysis of the effects of neuropeptides on the binding characteristics of monoamine receptors in membrane preparations ...
GUIDOLIN, DIEGO, Ciruela F, Genedani S, Guescini M, TORTORELLA, CINZIA, ALBERTIN, GIOVANNA, Fuxe K, Agnati LF   +7 more
openaire   +6 more sources