Results 51 to 60 of about 2,221,739 (262)

Receptor-Based Strategies for Overcoming Resistance in Cancer Therapy

Receptors
This review article explores the fundamental role of receptor targeting in overcoming drug resistance in cancer therapy, an area of critical concern given the persistently high rates of cancer morbidity and mortality globally.
Naresh Sah, Abdul Althaf Shaik, Ganesh Acharya, Manikantha Dunna, Ashok Silwal, Sejal Sharma, Sabiha Khan, Sounak Bagchi   +7 more
doaj   +1 more source

Referral Patterns and Diagnostic Timeliness in Pediatric Cancer: A Hospital‐Based Study in Indonesia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Timely diagnosis and treatment are critical for improving survival among children with cancer. In low‐ and middle‐income countries (LMICs), delays are common and may be influenced by fragmented referral pathways and diagnostic limitations.
Nur Melani Sari, Regina Hadi Putri, Fatimah Assyifa, Judith Spijkerman, Gertjan Johannes Kaspers, Susi Susanah   +5 more
wiley   +1 more source

Proxalutamide as Potential Inhibitor of ACE2 and TMPRSS2 Receptors?

Receptors
Background: The World Health Organization (WHO) declared a pandemic due to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the etiologic agent responsible for Coronavirus Disease 2019 (COVID-19).
Helyson Lucas Bezerra Braz, Aline Diogo Marinho, Antônio Marcelo Alves Lima, Raul Victor Magalhães Souza, João Alison de Moraes Silveira, Danilo Galvão Rocha, Mirna Marques Bezerra, Marcos Serrou do Amaral, Danilo da Silva Olivier, Geanne Matos de Andrade, Roberta Jeane Bezerra Jorge   +10 more
doaj   +1 more source

Exploring the kinetic selectivity of drugs targeting the β1‐adrenoceptor

Pharmacology Research & Perspectives, 2022
In this study, we report the β1‐adrenoceptor binding kinetics of several clinically relevant β1/2‐adrenoceptor (β1/2AR) agonists and antagonists. [3H]‐DHA was used to label CHO‐β1AR for binding studies. The kinetics of ligand binding was assessed using a
David A. Sykes, Mireia Jiménez‐Rosés, John Reilly, Robin A. Fairhurst, Steven J. Charlton, Dmitry B. Veprintsev   +5 more
doaj   +1 more source

Molecular pharmacological characterisation of recombinant and native NR2B- and NR3B- containing NMDA receptors [PDF]

, 2008
NMDA receptors are ionotropic, glutamate receptors which mediate fast excitatory transmissions within the central nervous system. They form tetrameric or pentameric heterologous complexes from seven NMDA receptor subunits NRl, NR2A-D and NR3A-B which ...
Chaffey, Heather Emily
core  

Venetoclax‐Based Therapy as a Bridge to Hematopoietic Stem Cell Transplantation in Relapsed or Refractory Pediatric Acute Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3‐mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials.
Katherine S. Colman, Deborah Meyran, Vajiranee Malalasekera, Heather Weerdenburg, Janine Campbell, Rachel Conyers, Stacie Wang, Hannah Walker, Seong Lin Khaw, Diane Hanna   +9 more
wiley   +1 more source

Astrocytic Receptor Systems of the Basal Ganglia

Receptors
Astrocytes are increasingly recognized as active participants of synaptic communication, yet their role in the basal ganglia circuitry remains poorly defined.
Aleksandar Tushevski, Linus Happe, Elena Stocco, Raffaele De Caro, Veronica Macchi, Andrea Porzionato, Aron Emmi   +6 more
doaj   +1 more source

Origin and diversification of steroids: Co-evolution of enzymes and nuclear receptors [PDF]

, 2010
Recent sequencing of amphioxus and sea urchin genomes has provided important data for understanding the origins of enzymes that synthesize adrenal and sex steroids and the receptors that mediate physiological response to these vertebrate steroids ...
Michael E. Baker
core  

L1CAM binds ErbB receptors through Ig-like domains coupling cell adhesion and neuregulin signalling. [PDF]

, 2012
During nervous system development different cell-to-cell communication mechanisms operate in parallel guiding migrating neurons and growing axons to generate complex arrays of neural circuits.
Carmen Grijota-Martinez (152374), Luis Garcia-Alonso, Sigrid Baars (152383), Cabedo, H, Emanuelle Donier, Carmen Grijota-Martinez, Gomez-Sanchez, JA, Lakomá, J, Emanuelle Donier (152367), Garcia-Alonso, L, Jose Antonio Gomez-Sanchez (152369), Jarmila Lakomá, Donier, E, Jarmila Lakomá (152379), Luis Garcia-Alonso (152388), Grijota-Martinez, C, Baars, S, Hugo Cabedo, Jose Antonio Gomez-Sanchez, Hugo Cabedo (152396), Sigrid Baars, Garcia Alonso, Luis, García-Alonso, L., Grijota Martínez, María Carmen, García-Alonso, Luis, Donier, Emanuelle, Garcia-Alonso Luis, Cabedo, Hugo, Baars Sigrid, Baars, Sigrid, Donier Emanuelle, Cabedo Hugo, Gomez Sanchez, Jose Antonio, Grijota-Martinez Carmen, Grijota Martínez, María del Carmen, Gómez-Sánchez, José A., Lakomá, Jarmila, Gomez-Sanchez Jose Antonio, Lakomá Jarmila   +38 more
core   +1 more source

Language, Culture, and Cancer: Qualitative Insights Into Communication Disparities Among Spanish‐Speaking Caregivers of Children With Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Latino children are projected to make up nearly one‐third of United States (US) children by 2060, and many of their caregivers speak Spanish. Prior survey research has documented communication difficulties for Spanish‐speaking caregivers of children with cancer, but contemporary qualitative data are limited.
Jenny Ruiz, Alejandra Curbelo‐Paz, Sonia Morales, Elizabeth Contreras, Amy Houtrow, Scott H. Maurer, Judy C. Chang   +6 more
wiley   +1 more source