Results 181 to 190 of about 1,270,897 (309)

Cross Kingdom Metabolic Engineering Paradigm Elevating Sustainable Protein Production

Advanced Science, EarlyView.
ABSTRACT Confronting the dual crisis of escalating global protein demand and unsustainable agriculture necessitates transformative solutions. Here, we pioneer evolutionary insights from maize nitrogen optimization via asparagine synthetase (ASNS) to rewire metabolism in Pichia pastoris.
Yuanyuan Du, Changyu Pi, Kai Hong, Le Gao, Xin Wu   +4 more
wiley   +1 more source

Construction of Recombinant <i>Mycobacterium smegmatis</i> Expressing the Pro-Apoptotic Protein BIK and Its Impact on Macrophage Apoptosis. [PDF]

Pathogens
Pang Y, Bi J.
europepmc   +1 more source

A 3D Human Bone and Bone Marrow‐on‐a‐Chip Model for In Vitro Bone Remodeling and Immune Cell Maintenance

Advanced Science, EarlyView.
This study presents a human Bone (and Bone Marrow)‐on‐a‐Chip model based on native human bone scaffolds and autologous cells. Dynamic perfusion and sequential cell seeding replicate the physiological bone remodeling process in vitro, enabling the long‐term culture of functional, mature bone marrow immune subpopulations.
Nina Stelzer, Melanie‐Jasmin Ort, Kristian Händler, Emely Bortel, Ioanna Maria Dimitriou, Martin Textor, Georg N. Duda, Janosch Schoon, Uwe Marx, Uwe Kornak, Annika Winter, Bernhard Hesse, Stefanie Donner, Sebastian Hardt, Oliver Klein, Simon Reinke, Malte Spielmann, Sven Geißler   +17 more
wiley   +1 more source

Protocol for efficient purification of endotoxin-free human recombinant tau protein. [PDF]

STAR Protoc
Karabova MK, Del Ser-Badia A, James WS, Cowley SA.   +3 more
europepmc   +1 more source

PRC2.1 Coordinates Peri‐Nucleolar H3K27me3‐Enriched Heterochromatin Organization and NPM1 Pentamerization to Maintain Nucleolar Integrity

Advanced Science, EarlyView.
PRC2.1(PCL2)‐coordinated H3K27me3‐enriched PNH establishes a spatial scaffold crucial for nucleolar integrity. As a crucial coordinator, PCL2 links PRC2.1 to chromatin organization and NPM1 assembly. This network‐based model reveals how chromatin modifications and nucleolar components cooperatively maintain nucleolar architecture, revealing novel ...
Lina Zhu, Wenqin Wang, Shuyun Chen, Gangyi Zhu, Zhen Wu, Yue Gu, Jingwen Xiong, Xu Zhang, Heng Liu, Kyoichi Isono, Youming Zhang, Jingjing Cao, Xiangzhi Li   +12 more
wiley   +1 more source

An engineered and scalable human cell-derived extracellular matrix demonstrates advantages over recombinant collagen in biomimicry and wound healing. [PDF]

Front Bioeng Biotechnol
Guo X, Ran X, Zhang Y, Liu B, Wen Z, Liu Y, Zhou M, Zang M, Wang J, Xu T.   +9 more
europepmc   +1 more source

Understanding: Recombination

The American Biology Teacher, 2003
openaire   +1 more source

Chemoproteomic Identification of AKT2 as a Paclitaxel‐Binding Protein via C─C Bond‐Linked Probe PTX‐4 in Paclitaxel‐Resistant Breast Cancer

Advanced Science, EarlyView.
ABSTRACT Breast cancer remains one of the most prevalent malignancies among women, and taxane‐based chemotherapies such as paclitaxel and docetaxel are central to standard treatment regimens. However, drug resistance in breast cancer limits therapeutic efficacy and contributes to recurrence and metastasis.
Kai Wang, Yuqing Yuan, Wei Shen, Xiuxiu Yang, Xiaokang Wu, Haihua Zhou, Yi Hu, Qing Zhu   +7 more
wiley   +1 more source

Single Radial Immunodiffusion (SRID) Assay for Quantitative Determination of Recombinant SOD Protein in a Brucellosis Vaccine Candidate: Method Development and Validation. [PDF]

Methods Protoc
Nakhanova G, Chervyakova O, Shorayeva K, Zhakypbek A, Moldagulova S, Ulankyzy A, Omurtay A, Shayakhmetov Y, Baiseit T, Absatova Z, Issabek A, Shynybekova G, Sadikaliyeva S, Nakhanov A, Jekebekov K, Kossylganova A, Zhaparkulova K, Kalykova A, Bekezhanova T, Atakanova A, Yershebulov Z, Zhugunissov K.   +21 more
europepmc   +1 more source

Molecular characterization of adenovirus from an ongoingmulti-centric keratoconjunctivitis study in India

Journal of Infection in Developing Countries, 2020
Ferdinamarie Sharmila Philomenadin, Mini Pritam Singh, Jayanti Shastry, Anil Chandra Phukan, Muruganandam Nagarajan, Subashini Kaliaperumal, Radha Kanta Ratho, Jagat Ram, Madhav Jagannath Sathe, Avinash Ingole, Darshana Babubhai Rathod, Benjamin Nongrum, Rehnuma Parvez, Vineeta Malik, Rahul Dhodapkar   +14 more
doaj   +1 more source