Results 51 to 60 of about 1,270,897 (309)

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Expression of the murine cytomegalovirus glycoprotein H by recombinant vaccinia virus [PDF]

, 1994
The sequence of the gene encoding glycoprotein H (gH) of murine cytomegalovirus (MCMV) strain Smith was determined and compared with the sequence of the gH of MCMV strain K181. Transcriptional analysis showed that gH is encoded by a large mRNA of 5.0 kb,
Rapp, Maria, Koszinowski, Ulrich H., Lucin, Pero, Messerle, Martin, Loh, Lambert C.   +4 more
core   +1 more source

Targeted drug delivery using nanobodies to deliver effective molecules to breast cancer cells: the most attractive application of nanobodies

Cancer Cell International
Targeted drug delivery is one of the attractive ways in which cancer treatment can significantly reduce side effects. In the last two decades, the use of antibodies as a tool for accurate detection of cancer has been noted. On the other hand, the binding
Mohadeseh Haji Abdolvahab, Pegah Karimi, Nasrin Mohajeri, Mohammad Abedini, Hamed Zare   +4 more
doaj   +1 more source

Dual blockade of CD47 and CD24 signaling using a novel bispecific antibody fusion protein enhances macrophage immunotherapy

Molecular Therapy: Oncolytics, 2023
CD47 and its receptor signal regulatory protein α (SIRPα) act as a dominant antiphagocytic, “don’t eat me” signal. Recent studies reveal CD24 as a novel target for cancer immunotherapy by macrophages in ovarian cancer and breast cancer.
Yun Yang, He Wu, Yan Yang, Yan Kang, Runjia He, Bei Zhou, Huaizu Guo, Jing Zhang, Jianqin Li, Chunpo Ge, Tianyun Wang   +10 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Production, characterization, and antigen specificity of recombinant 62-71-3, a candidate monoclonal antibody for rabies prophylaxis in humans [PDF]

, 2013
Rabies kills many people throughout the developing world every year. The murine monoclonal antibody (mAb) 62-71-3 was recently identified for its potential application in rabies postexposure prophylaxis (PEP).
Both, L, Bulmer-Thomas, B., Banyard, AC, Selden, D., Altmann, F, Craig van Dolleweerd (406086), David Selden (4911475), Selden, D, Ashley C Banyard (16267520), Both, L., Banyard, A.C., Edward Wright (4468198), Bulmer-Thomas, B, Fooks, AR, Friedrich Altmann (33138), Wright, E, van Dolleweerd, C., Fooks, A.R., Ma, J.K.C., Julian K C Ma (16267529), Leonard Both (16267517), van Dolleweerd, C, Ma, JK, Wright, E., Altmann, F., Anthony R Fooks (16267526), Bianca Bulmer-Thomas (16267523)   +26 more
core   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Investigation into the pharmacodynamics and pharmacokinetics of recombinant human interferon alfa-2b vaginal suppository following process optimization in chinese rhesus macaque

Scientific Reports
Recombinant human interferon Alfa-2b vaginal suppository is a gynecological preparation mainly made of interferon, commonly used to treat diseases related to viral infections such as cervical erosion. As a recombinant protein drug, it is important to pay
Xueyan Zhang, Baisong Zhou, Yihan Gong, Yulin Liu   +3 more
doaj   +1 more source

Recombinant Newcastle Disease Virus (NDV) Expressing Sigma C Protein of Avian Reovirus (ARV) Protects against Both ARV and NDV in Chickens

Pathogens, 2019
Newcastle disease (ND) and avian reovirus (ARV) infections are a serious threat to the poultry industry, which causes heavy economic losses. The mesogenic NDV strain R2B is commonly used as a booster vaccine in many Asian countries to control the disease.
Deep Prakash Saikia, Kalpana Yadav, Dinesh C. Pathak, Narayan Ramamurthy, Ajai Lawrence D’Silva, Asok Kumar Marriappan, Saravanan Ramakrishnan, Vikram N. Vakharia, Madhan Mohan Chellappa, Sohini Dey   +9 more
doaj   +1 more source

Unwinding to Recombine [PDF]

Molecular Cell, 2012
The MCM proteins are best known for their role in DNA replication, MCM2-7 forming the replicative helicase. Now, two reports in this issue of Molecular Cell, Nishimura et al. (2012) and Lutzmann et al. (2012) show the less well understood MCM8 and MCM9 to be crucial for effective homologous recombination.
Guilbaud, Guillaume, Sale, Julian E.
openaire   +2 more sources