Results 141 to 150 of about 532,969 (259)

m6A‐Mediated Glycolysis by IL‐37 Drives T Cell Metabolic Reprogramming to Regulate Colitis

Advanced Science, EarlyView.
This study identifies an IL‐37/SIGIRR‐METTL14 regulatory axis that suppresses global m6A modification in CD4+ T cells. IL‐37 signaling, mediated through SIGIRR, inhibits IRAK4 and JNK phosphorylation, leading to downregulation of the methyltransferase METTL14.
Xiaoyan Wang, Jiadong Yu, Guolin Li, Ya Li, Fanlian Zeng, Jing Hu, Yifan Zhou, Chengcheng Yue, Qixiang Zhao, Chen Zhang, Hong Zhou, Fulei Zhao, Yawen Hu, Pei Zhou, Linna Gu, Yuting Feng, Mingxiang He, Shishi Huang, Xiaochi Sun, Xinmeng Wang, Jie Tang, Xinyu Zeng, Wenling Wu, Nongyu Huang, Xinai Cui, Kaijun Cui, Jiong Li   +26 more
wiley   +1 more source

The development of a canine single-chain phage antibody library to isolate recombinant antibodies for use in translational cancer research. [PDF]

Cell Rep Methods
Lisowska M, Worrall EG, Zavadil-Kokas F, Charlton K, Murray E, Mohtar MA, Krejcir R, Hrabal V, Brydon J, Urionabarrenetxea AG, Saliba DG, Grima M, Kalathiya U, Muller P, Krejci A, Vojtesek B, Ball KL, Fahraeus R, Argyle DJ, Parys M, Hupp TR.   +20 more
europepmc   +1 more source

Continuous capture of recombinant antibodies by ZnCl ₂ precipitation without polyethylene glycol. [PDF]

Eng Life Sci, 2020
Dutra G, Komuczki D, Jungbauer A, Satzer P.   +3 more
europepmc   +1 more source

Genome‐Wide In Vivo RNAi Screening Identifies HOXD4 as a Tumor Metastasis Suppressor in Colorectal Cancer

Advanced Science, EarlyView.
Metastasis remains a major challenge in colorectal cancer. Using an in vivo shRNA screening system, this study identifies Homeobox D4 as a key metastasis suppressor. Reduced Homeobox D4 expression is associated with aggressive tumor features. Functional and mechanistic analyses show that it inhibits epithelial‐mesenchymal transition by repressing ...
Zhi‐hua Ye, Wen‐jing Luo, Lu Li, Wen‐di Shuai, Ling Zhou, You‐fa Duan, Xue Chen, Jun‐kai Zhang, Wenlin Huang, Ran‐yi Liu   +9 more
wiley   +1 more source

Expression and characterization of recombinant antibodies against H7 subtype avian influenza virus and their diagnostic potential. [PDF]

Front Microbiol
Wang S, Zhang Y, Zhou X, Ma Y, Shi J, Jiang Y, Li Y, Tian G, Wang X.   +8 more
europepmc   +1 more source

Recombinant Antibodies with Unique Specificities Allow for Sensitive and Specific Detection of Uncarboxylated Osteocalcin in Human Circulation. [PDF]

Calcif Tissue Int, 2020
Arponen M, Brockmann EC, Kiviranta R, Lamminmäki U, Ivaska KK.   +4 more
europepmc   +1 more source

FGF13 Deficiency Ameliorates Paclitaxel‐Induced Neuropathic Pain by Inhibiting VASH1‐Mediated Microtubule Detyrosination to Promote Mitophagy

Advanced Science, EarlyView.
FGF13 is upregulated in DRG neurons of PIPNP model mice. DRG neuron‐specific knockout of FGF13 ameliorates PIPNP symptoms. Mechanistically, FGF13 potentiates microtubule detyrosination by promoting VASH1 binding to microtubules. FGF13 knockout suppresses VASH1‐mediated microtubule detyrosination and promotes α‐tubulin tyrosination.
Yiming Dong, Yidan Wang, Simeng Lv, Zishan Dong, Kaixi Zhi, Xiuhua Guo, Xuyan Li, Ruoxi Yu, Yiyi Zhang, Siyuan Cheng, Chuan Wang   +10 more
wiley   +1 more source

Development of Recombinant Antibodies and Its Application in Immunomagnetic Separation-Based Rapid Detection of Vibrio cholerae in Aquatic Environments. [PDF]

J Microbiol Biotechnol
Zhang H, Wang Q, Zhuang H, Lin Q, Wang W, Ye F, Nawaz S, Hu J, Huang C, Yin H, Sun W, Han X, Jiang W.   +12 more
europepmc   +1 more source

Single‐Cell Dissection of Therapy‐Induced Remodeling Uncovers a Fibroblast‐Driven Immunosuppressive Niche and Targetable Vulnerabilities in Lethal Prostate Cancer

Advanced Science, EarlyView.
Single‐cell longitudinal profiling reveals that androgen‐deprivation therapy induces a DPT+ fibroblast‐complement axis that suppresses macrophage inflammation and drives CD8+ T cell exhaustion in prostate cancer. Concurrently, resistant epithelial subpopulations persist and engage TSPAN1‐ and NRXN1‐mediated programs promoting CRPC and neuroendocrine ...
Yang Chen, Dandan Dong, Jinling Liao, Naikai Liao, Mengqi Liu, Qin Zhang, Siting Chen, Qi Liu, Ying Lu, Tianyu Li, Chunlin Zou, Qiong Song, Qiuyan Wang, Jian Liang, Qiji Xie, Chengyang Li, Mengyun Wang, Jiwen Cheng, Zengnan Mo, Gong‐Hong Wei   +19 more
wiley   +1 more source

Exploring Gluten Assessment in Marketed Products through a Sandwich ELISA Methodology Based on Novel Recombinant Antibodies. [PDF]

Foods
Garcia-Calvo E, García-García A, Rodríguez S, Martín R, García T.   +4 more
europepmc   +1 more source