Results 251 to 260 of about 810,282 (282)

Recombinant therapeutic antibodies

Applied Microbiology and Biotechnology, 2007
Recombinant antibody technology has revolutionized the development of antibody therapeutics. This minireview offers an overview of enabling technologies and future prospects of this rapidly progressing field.
openaire   +2 more sources

Recombinant antibody fragments

Current Opinion in Biotechnology, 1998
Recombinant antibodies and their fragments now represent over 30% of all biological proteins undergoing clinical trials, which recently culminated in FDA approval for the first engineered cancer therapeutic antibody. Other successful applications include both the effective enhancement of the human immune response for cancer therapy and the reduction of
openaire   +2 more sources

Recombinant antibody fragment production

Methods, 2017
Recombinant antibodies are now very important in both therapeutics and diagnostics and offer significant advantages over conventional antibodies. The generation of a single-chain variable antibody fragment (scFv) (a common and important recombinant antibody format) is used to demonstrate the construction of a recombinant antibody library. An immunotube-
H, Ma, R, O'Kennedy
openaire   +2 more sources

Generation of Recombinant Antibodies

Molecular Biotechnology, 1999
Recombinant antibody technology is opening new perspectives for the development of novel therapeutic and diagnostic agents. In this review we focus on advances in the generation of both genetically engineered humanized and fully human monoclonal antibodies. Methods for their production in different expression systems are also discussed.
S M, Kipriyanov, M, Little
openaire   +2 more sources

Monoclonal Antibodies Against Recombinant AtHOS15

Hybridoma, 2012
Histone modifications are important components of transcriptional regulation and chromatin-based regulatory processes. In addition, WD40-repeat protein and several other components are involved in these functions. Here we present the development of monoclonal antibodies (MAbs) against Arabidopsis HOS15, a WD40-repeat protein.
Siyoung, Lee, Hyeong Cheol, Park, Suyoung, Bae, Jaewoo, Hong, Jida, Choi, Kwangwon, Hong, Hyunjhung, Jhun, Kangchang, Kim, Eusom, Kim, Seounghyun, Jo, Woe-Yeon, Kim, Dae-Jin, Yun, Soohyun, Kim   +12 more
openaire   +2 more sources

Production systems for recombinant antibodies

Frontiers in Bioscience, 2008
Recombinant antibodies are the fastest growing class of therapeutic proteins. Furthermore, antibodies are key detection reagents in research and diagnostics. The increasing demand for antibodies with regards to amount and quality resulted in the development of a variety of recombinant production systems employing gram-negative and gram-positive ...
Thomas, Schirrmann, Laila, Al-Halabi, Stefan, Dübel, Michael, Hust   +3 more
openaire   +2 more sources

Recombinant Antibodies in Cancer Therapy

Current Protein & Peptide Science, 2006
The application of recombinant immunotoxin and radioimmunoconjugate in Cancer therapy has revived the "magic bullet" concept predicted a century ago. Many of the recombinant antibodies have received FDA approval for various indication of cancer in recent years and numerous others are in clinical trials.
M S, Nayeem, Rizwan H, Khan
openaire   +2 more sources

Recombinant monoclonal antibody technology

Transfusion Clinique et Biologique, 2002
With the development of murine hybridoma technology over a quarter century ago, the ability to produce large quantities of well-characterized monoclonal antibody preparations revolutionized diagnostic and therapeutic medicine. For many applications in transfusion medicine, however, the production of serological reagents in mice has certain biological ...
openaire   +2 more sources

Manufacture of recombinant polyclonal antibodies

Biotechnology Letters, 2007
Polyclonal antibody therapy in the form of hyper-immune serum has for more than a century been used for treatment of many infectious diseases. However, with the emergence of first antibiotics and later recombinant monoclonal antibody therapy, the use of hyper-immune serum has declined.
S K, Rasmussen, L K, Rasmussen, D, Weilguny, A B, Tolstrup   +3 more
openaire   +2 more sources

Recombinant antibodies for environmental analysis

Analytical and Bioanalytical Chemistry, 2003
Initial steps of antibody engineering in the late eighties revolutionized the technology of antibody production, particularly in the area of immunotherapy and diagnostics. Hallmarks that seemed to be out of reach for a long time are now the state of the art, e.g.
K, Kramer, B, Hock
openaire   +2 more sources