Results 261 to 270 of about 574,921 (308)
Some of the next articles are maybe not open access.
Recombinant Monoclonal Antibodies
2007Recombinant antibody technology is a rapidly evolving field that enables the study and improvement of antibody properties by means of genetic engineering. Moreover, the functional expression of antibody fragments in Escherichia coli has formed the basis for antibody library generation and selection, a powerful method to produce human antibodies for ...
Mariel, Donzeau, Achim, Knappik
openaire +2 more sources
Recombinant Antibodies for the Generation of Antibody Arrays
2011Affinity proteomics, mainly represented by antibody microarrays, has in recent years been established as a powerful tool for high-throughput (disease) proteomics. The technology can be used to generate detailed protein expression profiles, or protein maps, of focused set of proteins in crude proteomes and potentially even high-resolution portraits of ...
Carl A K, Borrebaeck, Christer, Wingren
openaire +2 more sources
Recombinant antibody fragments
Current Opinion in Biotechnology, 1998Recombinant antibodies and their fragments now represent over 30% of all biological proteins undergoing clinical trials, which recently culminated in FDA approval for the first engineered cancer therapeutic antibody. Other successful applications include both the effective enhancement of the human immune response for cancer therapy and the reduction of
openaire +2 more sources
Recombinant therapeutic antibodies
Applied Microbiology and Biotechnology, 2007Recombinant antibody technology has revolutionized the development of antibody therapeutics. This minireview offers an overview of enabling technologies and future prospects of this rapidly progressing field.
openaire +2 more sources
Production systems for recombinant antibodies
Frontiers in Bioscience, 2008Recombinant antibodies are the fastest growing class of therapeutic proteins. Furthermore, antibodies are key detection reagents in research and diagnostics. The increasing demand for antibodies with regards to amount and quality resulted in the development of a variety of recombinant production systems employing gram-negative and gram-positive ...
Thomas, Schirrmann +3 more
openaire +2 more sources
Recombinant Antibodies in Cancer Therapy
Current Protein & Peptide Science, 2006The application of recombinant immunotoxin and radioimmunoconjugate in Cancer therapy has revived the "magic bullet" concept predicted a century ago. Many of the recombinant antibodies have received FDA approval for various indication of cancer in recent years and numerous others are in clinical trials.
M S, Nayeem, Rizwan H, Khan
openaire +2 more sources
Engineering recombinant antibodies for immunotherapy
Cell Biophysics, 1995Recombinant antibody fragments binding with high affinity to their target can be obtained either from hybridomas or directly from antibody libraries on filamentous phage. These fragments are devoid of any activity other than antigen binding, and have to be processed and functionalized in order to be suitable for clinical applications.
D, Neri, H, Petrul, G, Roncucci
openaire +2 more sources
The use of recombinant antibodies in proteomics
Current Opinion in Biotechnology, 2000Recombinant antibodies are becoming increasingly important in the field of proteomics. Recent advances include the development of large phage-antibody libraries that contain high-affinity binders to almost any target protein, and new methods for high-throughput selection of antibody-antigen interactions.
L J, Holt +3 more
openaire +2 more sources
Recombinant antibodies for environmental analysis
Analytical and Bioanalytical Chemistry, 2003Initial steps of antibody engineering in the late eighties revolutionized the technology of antibody production, particularly in the area of immunotherapy and diagnostics. Hallmarks that seemed to be out of reach for a long time are now the state of the art, e.g.
K, Kramer, B, Hock
openaire +2 more sources
Recombinant antibody fragment production
Methods, 2017Recombinant antibodies are now very important in both therapeutics and diagnostics and offer significant advantages over conventional antibodies. The generation of a single-chain variable antibody fragment (scFv) (a common and important recombinant antibody format) is used to demonstrate the construction of a recombinant antibody library. An immunotube-
H, Ma, R, O'Kennedy
openaire +2 more sources