Results 271 to 280 of about 399,275 (342)

Balanced Expression of the Diiron Oxygenase BioE Is Essential for Biotin Homeostasis in Elizabethkingia meningoseptica

Advanced Science, EarlyView.
BioE is a new diiron oxygenase that catalyzes the conversion of long‐chain acyl groups into pimeloyl thioester, initiating biotin synthesis. The overexpression of EmBioE disrupts lipid metabolic homeostasis, requiring repressor BioL to maintain a balance between long‐chain fatty acids and biotin synthesis.
Meng Zhang, Ying‐ying Fu, Xiaoqiang Yang, Qiuying Qin, Xinyu Su, Jiaming Fang, Yanhua Kang, Qingwen He, Zhi Ruan, Yongchang Xu   +9 more
wiley   +1 more source

Recombinant Production, SpeciesSpecific Activity at the TRPA1 Channel, and Significance of the N-Terminal Residue of ProTx-I Toxin from Thrixopelma Pruriens Tarantula Venom. [PDF]

Acta Naturae
Shulepko MA, Zhang M, Zhivov EA, Kulbatskii DS, Paramonov AS, Che Y, Kuznetsov AV, Popov AV, Kirpichnikov MP, Shenkarev ZO, Lyukmanova EN.   +10 more
europepmc   +1 more source

PARPi Combining Nanoparticle LIN28B siRNA for the Management of Malignant Ascites

Advanced Science, EarlyView.
This study demonstrates that co‐inhibition of LIN28B and PARP using siLin28b/DSSP@lip‐PEG‐FA nanoparticles in combination with the PARP inhibitor BMN673 effectively suppresses the accumulation of malignant ascites associated with advanced cancers.
Yan Fang, Qian Shen, Yao Lin, Jing Zhu, Xiaolan Zhu, Rui Huang, Yijia Wu, Feiyang Shen, Qian Li, Guopei Zheng, Zhe Zhang, Qian Chu, Junhao Hu, Jianfeng Shen   +13 more
wiley   +1 more source

Protective effects of an Fc-engineered PD-L1 fusion protein in a spontaneous abortion model and a Th17 cell-induced pregnancy loss model. [PDF]

Front Pharmacol
Li G, Wang T, Tan D, Jin Y, Zhou X, Ai H, Zheng X, Ren X, Hu S, Lei C, Fu W.   +10 more
europepmc   +1 more source

p16Ink4a‐Positive Hepatocytes Drive Liver Fibrosis Through Activation of LIFR Family Pathway

Advanced Science, EarlyView.
This study found that, following the long‐term CCl4 treatment, p16high hepatocytes appeared in zone 3, spatially co‐localizing with fibrotic areas. A specific cluster of p16high hepatocytes upregulated CTF1/LIF expression which induced HSC activation and further liver fibrosis, as revealed by single cell transcriptomic analysis.
Koji Nishikawa, Teh‐Wei Wang, Satoshi Kawakami, Shota Tanimoto, Kiyoshi Yamaguchi, Taketomo Kido, Masamichi Kimura, Tsunekazu Hishima, Yuki T. Okamura, Satotaka Omori, Takumi Iritani, Toshikaze Chiba, Takehiro Jimbo, Michio Katano, Kansuporn Kamataki, Ryoichi Yokoyama, Eigo Shimizu, Kiminori Kimura, Satoshi Yamzaki, Seiya Imoto, Yoichi Furukawa, Atsushi Miyajima, Yoshikazu Johmura, Makoto Nakanishi   +23 more
wiley   +1 more source

Optimization of thrombopoietin mimetic peptide fusion proteins with albumin-binding domain for enhanced bioactivity and extended half-life. [PDF]

Sci Rep
Ying J, Zheng Y, Xu X, Yang J, Hu A, Gao G.   +5 more
europepmc   +1 more source

The Efficacy, Immunogenicity and Safety of a Recombinant Tetrameric GE-FC Fusion Protein Vaccine for Herpes Zoster in Adults 40 Years of Age or Older: A Multicentre, Randomised, Double-Blind, Placebo-Controlled, Phase 3 Trial

Pengfei Jin, Yaru Quan, Xuefen Gao, Mingwei Wei, Xiang Cao, Hongxing Pan, Heng Tao Shen, Qili Zhang, Qing Xu, Zhao Wang, Xiaodong Liu, Jinmei Xu, Kang-Wei Xu, William Wan, Yeqing Tong, Li Zhang, Lin Xu, Jingxin Li, anon Group   +18 more
openalex   +1 more source

Microenvironment Self‐Adaptive Nanoarmor to Address Adhesion‐ and Colonization‐Related Obstacles in Impaired Intestine Promote Bacteriotherapy Against Parkinson's Disease

Advanced Science, EarlyView.
A microenvironment self‐adaptive nanoarmor is developed to effectively address the adhesion‐ and colonization‐related challenges posed by multiple physiological and pathological characteristics in the intestine. L. plantarum@MPN@CS showed significant therapeutic potential in treating Parkinson's disease (PD), a model for extraintestinal disorders, as ...
Limeng Zhu, Yuyu Wu, Yingjie Chen, Xiyi Chen, Xingjie Zan, Yanlong Liu, Wujun Geng   +6 more
wiley   +1 more source

Recombinant <i>lactococcus lactis</i> expressing HPV-16 E6E7 dual antigens for potential cervical cancer treatment enhances dendritic cell vaccines efficacy. [PDF]

Future Microbiol
Li Y, Wei X, Li Y.
europepmc   +1 more source