Results 51 to 60 of about 262,160 (309)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Novel Biopesticides Based on Recombinant Avidin for Protection of Crops Against Insect Pests [PDF]

, 2012
Farmers are required to increase their food productivity to meet the demand from a continually enlarging population. A major constraint on meeting this requirement is the damage created by insect pests.
HINCHLIFFE, GARETH
core  

Fusing the 3’UTR of seed storage protein genes leads to massive recombinant protein accumulation in seeds

Scientific Reports, 2023
The demand for recombinant proteins is rising dramatically, and effective production systems are currently being developed. The production of recombinant proteins in plants is a promising approach due to its low cost and low risk of contamination of the ...
Masatake Kanai, Masaya Sugiyama, Maki Kondo, Kenji Yamada, Mikio Nishimura, Shoji Mano   +5 more
doaj   +1 more source

Antigenicity and Immunogenicity Analysis of the E. coli Expressed FMDV Structural Proteins; VP1, VP0, VP3 of the South African Territories Type 2 Virus

Viruses, 2021
An alternative vaccine design approach and diagnostic kits are highly required against the anticipated pandemicity caused by the South African Territories type 2 (SAT2) Foot and Mouth Disease Virus (FMDV).
Guoxiu Li, Ashenafi Kiros Wubshet, Yaozhong Ding, Qian Li, Junfei Dai, Yang Wang, Qian Hou, Jiao Chen, Bing Ma, Anna Szczotka-Bochniarz, Susan Szathmary, Yongguang Zhang, Jie Zhang   +12 more
doaj   +1 more source

Obtaining of the recombinant Rhil7-Cbd fusion protein

Faktori eksperimental'noi evolucii organizmiv, 2020
Aim. The purpose was to obtain the recombinant fusion protein based on the human interleukin-7 (rhIL7) and cellulose binding domain (CBD). Methods. The DNA sequences encoding rhIL-7 and CBD were subcloned into the pET24a(+). Vector containing the 6His-tag sequence for further chromatographic purification of the target protein. The cells of E.
M. O. Usenko, O. B. Gorbatiuk, O. V. Okunev, D. M. Irodov, M. V. Koval’chuk, V. A. Kordium   +5 more
openaire   +2 more sources

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Functional analysis of the Bunyamwera orthobunyavirus Gc glycoprotein [PDF]

, 2009
The virion glycoproteins Gn and Gc of Bunyamwera orthobunyavirus (BUNV, family Bunyaviridae) are encoded by the M RNA genome segment and have roles in both viral attachment and membrane fusion.
Elliott, Richard Michael, Goli, J., Shi, X., Clark, Gordon, Clark, G., Brauburger, Kristina, Brauburger, K., Shi, Xiaohong, Goli, Josthna, Elliott, R.M.   +9 more
core   +1 more source

DEVELOPMENT OF FUSION RECOMBINANT PROTEINS BASED ON VP6 AND VP8 OF HUMAN ROTAVIRUS A

Инфекция и иммунитет, 2014
Rotaviruses are the most frequent cause of children enteritis. This infection often leads to severe dehydration of organism. Many infectious diseases are accompanied by fluid loss being the most common cause of death.
I. V. Dukhovlinov, E. G. Bogomolova, E. A. Fedorova, A. S. Simbirtsev   +3 more
doaj   +1 more source

The temperature of growth and sporulation modulates the efficiency of spore-display in Bacillus subtilis

Microbial Cell Factories, 2020
Background Bacterial spores displaying heterologous antigens or enzymes have long been proposed as mucosal vaccines, functionalized probiotics or biocatalysts.
Claudia Petrillo, Stefany Castaldi, Mariamichela Lanzilli, Anella Saggese, Giuliana Donadio, Loredana Baccigalupi, Ezio Ricca, Rachele Isticato   +7 more
doaj   +1 more source

Maltose-Binding Protein (MBP), a Secretion-Enhancing Tag for Mammalian Protein Expression Systems. [PDF]

PLoS ONE, 2016
Recombinant proteins are commonly expressed in eukaryotic expression systems to ensure the formation of disulfide bridges and proper glycosylation. Although many proteins can be expressed easily, some proteins, sub-domains, and mutant protein versions ...
Raphael Reuten, Denise Nikodemus, Maria B Oliveira, Trushar R Patel, Bent Brachvogel, Isabelle Breloy, Jörg Stetefeld, Manuel Koch   +7 more
doaj   +1 more source