Results 51 to 60 of about 15,000 (182)
De Novo Synthesis in Cancer Immunotherapy: Applications and Prospects
De novo protein design creates novel structures for cancer immunotherapy, integrating rational design principles like modularity and specificity. Leveraging computational tools, it optimizes cytokine engineering, adoptive cellular therapy, and checkpoint regulation to enhance antitumor immunity.
Yang Jin, Yanfeng Wu, Jianhua Luo
wiley +1 more source
ORIGINAL PAPER
Erythropoietin therapy in chronic renal failure patients prior to hemodialysis
The human recombinant erythropoietin (hrEpo) is crucial in anemia treatment options in chronic renal failure patients undergoing regular hemodialysis therapy.
Jacek Rysz +2 more
doaj
ABSTRACT This report describes a 25‐year‐old, intact male brown bear (Ursus arctos) presenting with weight loss, diarrhea, melena, apathy, and a 12% hematocrit. Ultrasound showed proximal duodenal wall thickening with submucosal cysts and a large, heterogeneous, highly vascularized mass in the descending duodenum, containing small gas pockets and ...
Mariana Giendruczak de Souza +8 more
wiley +1 more source
Biological evaluation of recombinant human erythropoietin in pharmaceutical products
The potencies of mammalian cell-derived recombinant human erythropoietin pharmaceutical preparations, from a total of five manufacturers, were assessed by in vivo bioassay using standardized protocols.
A.S. Ramos +5 more
doaj +1 more source
ABSTRACT Despite the transformative impact of cancer immunotherapies such as immune checkpoint blockade, durable clinical responses remain limited. Increasing evidence indicates that antitumor immunity is governed not only by the tumor microenvironment, but also by systemic immune regulation mediated by peripheral immune organs. Among these, the spleen
Yuehua Liu, Xiaoqian Nie, Xiaofei Gao
wiley +1 more source
We investigate blood flow velocity at ischemia/reperfusion early stages and at its human recombinant erythropoietin correction. Transient hyperemia absence after ischemia/reperfusion at early stages was determined.
S. A. Alehin +7 more
doaj
Porcine kidney xenotransplantation: From primate models to clinical reality
In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo +3 more
wiley +1 more source
The orphan cytokine receptor-like factor 3 (CRLF3) was identified as a neuroprotective erythropoietin receptor in locust neurons and emerged with the evolution of the eumetazoan nervous system.
Nina Hahn +8 more
doaj +1 more source
Validation of isoelectric focusing method for recombinant erythropoietin detection in human urine
Erythropoietin (EPO) is a substance that stimulates red blood cell production, increasing muscle oxygenation and is secreted naturally by the body and excreted in urine in low concentrations.
Ana Sofia Rodrigues Tavares
doaj +1 more source
Background and Aims Erythropoietin (EPO) is a glycoprotein hormone which is required to regulate the production of red blood cells. Deficiency of EPO is known to cause anemia in chronically infected renal patients and they require regular blood ...
Kausar Humera +8 more
doaj +1 more source

