Results 141 to 150 of about 12,905,954 (250)

Consequences of growth hormone deficiency in adults and the benefits and risks of recombinant human growth hormone treatment. A review paper

, 1995
Growth hormone deficiency (GHD) in adults is now recognized as a specific clinical syndrome with characteristic symptoms and signs. Thus, the patients are overweight, have an abnormal body composition (excess body fat and a decrease in the extracellular ...
Johansson, J O, Bengtsson, B A, Rosén, T, Johannsson, Gudmundur,   +3 more
core  

Regulatory harmonization: Evolution, globalization and future directions

British Journal of Clinical Pharmacology, EarlyView.
Regulatory harmonization has become an increasingly important and accepted approach to streamline regulatory review processes and expedite access to safe, effective and high‐quality medicines globally. This review explores the evolution and current status of regulatory harmonization, convergence and reliance initiatives.
Orin Chisholm, Elaine Y. L. Blair, Christine Y. Lu   +2 more
wiley   +1 more source

Growth hormone deficiency in adults: a new indication for recombinant human growth hormone [PDF]

Journal of Internal Medicine, 1996
openaire   +2 more sources

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

Biomaterials for modulating cellular responses of endogenous tendon stem/progenitor cells: A promising avenue for tendon regeneration

BMEMat, EarlyView.
This review comprehensively summarizes emerging biomaterial‐based strategies and underlying mechanisms for modulating endogenous tendon stem/progenitor cells (TSPCs). It offers the most recent insights into TSPC physiology and potential applications of tissue engineering and regenerative medicine in tendons.
Zeyu Zhu, Renwang Sheng, Mumin Cao, Ludvig J. Backman, Yucheng Gao, Hao Wang, Cheng Zhang, Jialin Chen, Wei Zhang, Yunfeng Rui   +9 more
wiley   +1 more source

Cost-effectiveness of a connected injection device for daily somatropin therapy in pediatric growth hormone deficiency in Spain: a scenario-based microsimulation analysis using real-world data

Journal of Comparative Effectiveness Research
Aim: Growth hormone deficiency (GHD) in pediatric patients is characterized by impaired growth and reduced quality of life. Recombinant human growth hormone therapy requires consistent daily administration, yet adherence remains challenging. Electronic
Antonio de Arriba, Claudia Roeder, Emilia Nivelle, Paula van Dommelen, Jose J Alcon Saez, Cristina Latre Gorbe, Heidi de los Santos Real, Irene Sánchez-Collado, Falko Boehm, Cristina Masseria   +9 more
doaj   +1 more source

Bridging the translational gap in clinical nanomedicine: From rational design to clinical reality

BMEMat, EarlyView.
Nanotechnology offers a multi‐faceted approach to modern healthcare, encompassing high‐sensitivity diagnostic imaging, innovative vaccine delivery, and targeted therapeutics. This review explores how these nanomedicine applications address critical challenges in cancer recurrence and the treatment of neurologic and respiratory diseases to combat rising
Ahmed H. Ghonaim, Marwa Ahmed El‐Naka, Wedad M. Nageeb, Atta Ullah Khan, Noura M. Seleem, Aliaa Abdelghafar, Doaa Zamel, Yang Liu, Qigai He, Wentao Li   +9 more
wiley   +1 more source

Increased chromosome fragility in lymphocytes of short normal children treated with recombinant human growth hormone

, 1993
A few years ago it was reported that some growth-hormone-deficient children had developed leukemia following therapy with human growth hormone. This raised concern that this therapy may stimulate tumor development.
VERNOLE, PATRIZIA, Boscherini, B, Vernole, P, Tedeschi, B, Cianfarani, S, Sanna, ML, Boscherini, B., Spadoni, GL, CIANFARANI, STEFANO, Caporossi, D, Nicoletti, B   +10 more
core  

Harnessing bacterial extracellular vesicles for bone and cartilage organoids

BMEMat, EarlyView.
This review presents bacterial extracellular vesicles (BEVs) as programmable bioactive regulators for bone and cartilage organoids by delivering functional cargos that modulate skeletal remodeling. It highlights key engineering strategies and future directions to advance next‐generation organoid models for bone aging related diseases.
Han Liu, Xukun Lv, Ting Cheng, Lei Yan, Yuxiao Lai, Keying Guo, Yingying Jing, Hao Shen, Jiacan Su   +8 more
wiley   +1 more source

Adult Growth Hormone Deficiency. What does the newest hormone replacement therapy do?

, 2001
All patients with known pituitary or hypothalamic disease, or surgery or radiation treatment to the area could have growth hormone deficiency. Growth hormone deficiency in adults is an approved indication for recombinant growth hormone treatment in ...
Wallace, J. D., Wallace, Jennifer D., Cuneo, Ross C., Cuneo, R. C.   +3 more
core