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Management of Recombinant Human Growth Hormone Therapy at Puberty
Hormone Research in Paediatrics, 1998Treatment modalities for growth hormone (GH) substitution in GH-deficient children at puberty is still a matter of debate. Although circulating GH levels increase during puberty, it has not been proven that the increase of exogenous GH is necessary for a normal pubertal growth spurt.
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Recombinant DNA Synthesis of Human Growth Hormone
1986Human growth hormone (hGH) is a polypeptide of approximately 22,000 daltons in size that is synthesized in the pituitary. Mature hGH has been produced in Escherichia coli bacteria using recombinant DNA technology(1) using the scheme outlined in Fig. 1. The process involved cloning of cDNA to the pituitary hGH mRNA(2) and the subsequent adapting of the ...
Michael J. Ross +4 more
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Pediatric Nephrology, 1996
Many of the metabolic actions of growth hormone (GH) are mediated through insulin-like growth factors or somatomedins. Recombinant human insulin-like growth factor-I (rhIGF-I) has a dichotomous insulin-like and GH-like action when used in different clinical situations in humans.
N, Mauras, M W, Haymond
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Many of the metabolic actions of growth hormone (GH) are mediated through insulin-like growth factors or somatomedins. Recombinant human insulin-like growth factor-I (rhIGF-I) has a dichotomous insulin-like and GH-like action when used in different clinical situations in humans.
N, Mauras, M W, Haymond
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Introduction: Discovery of Growth Hormone and Synthesis of Recombinant Human Growth Hormone
2016The most famous likely growth hormone (GH)-deficient individual was Charles S. Stratton (born February 4, 1838), nicknamed General Tom Thumb by P.T. Barnum who discovered him at age of 10. He was born to parents of normal height who were first cousins. His birth weight was nine and a half pounds, and he grew steadily until age 18 months. Thereafter, he
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Zhonghua yi xue za zhi = Chinese medical journal; Free China ed, 1994
This study was to evaluate the efficacy, safety and immunogenicity of recombinant human growth hormone (rhGH) in treatment of children with growth hormone deficiency (GHD).We selected 15 children with GHD for a 12-month clinical trial and separated them into three groups with each 5 patients receiving one of the 3 tested rhGH (Saizen by Serono, Aubonne,
K C, Shih +6 more
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This study was to evaluate the efficacy, safety and immunogenicity of recombinant human growth hormone (rhGH) in treatment of children with growth hormone deficiency (GHD).We selected 15 children with GHD for a 12-month clinical trial and separated them into three groups with each 5 patients receiving one of the 3 tested rhGH (Saizen by Serono, Aubonne,
K C, Shih +6 more
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Whither Recombinant Human Growth Hormone?
Annals of Internal Medicine, 1996Christos S. Mantzoros, Alan C. Moses
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[How safe is the recombinant human growth hormone?]
Revista medica del Instituto Mexicano del Seguro Social, 2018In this paper, several aspects related to the safety of the use of biosynthetic human growth hormone are reviewed. For example, its classification as a biosynthetic drug, the phases that need to be performed in Mexico to verify its safety (obtaining, purification, preclinical studies, clinical trials, and finally observational clinical studies), as ...
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[Use of recombinant Human Growth Hormone (rHGH)].
Revista medica del Instituto Mexicano del Seguro Social, 2018Recombinant human growth hormone, synthesized in E.coli or mammalian cells cultures, is since 1985, a useful therapeutic resource to increase growth velocity and final height. In this paper are discussed the four phases (aims, security and efficacy, utility and efficiency) indispensables to define the start of treatment, as well as the absolute ...
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