Results 211 to 220 of about 75,972 (251)
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Recombinant human growth hormone.
ANNA journal, 1994Recombinant human growth hormone was initially used as replacement therapy in children with short stature. As rhGH has become more readily available, it has been tested in a variety of other individuals who have delayed growth. Children with ESRD experience significant problems with delayed growth, thus replacement therapy with rhGH has been used in ...
B, Wise, B, Case
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Use of Recombinant Human Growth Hormone in Children with Thalassemia
Hormone Research in Paediatrics, 2009<i>Background:</i> Growth failure occurs in children with chronic anemias and, in particular, in approximately 30% of those with thalassemia. <i>Methods:</i> We assessed recombinant human growth hormone (rhGH) use in a large cohort of children with thalassemia enrolled in the Pfizer International Growth Study Database (KIGS ...
Mitchell E, Geffner, Hanna, Karlsson
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Expanded spectrum of recombinant human growth hormone therapy
Current Opinion in Pediatrics, 2002The efficacy of recombinant human growth hormone in the treatment of growth hormone deficiency is well established. In recent years, the use of recombinant human growth hormone as a therapeutic modality has greatly increased and has expanded beyond the realm of replacement for growth hormone deficiency.
Maria J, Henwood +2 more
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Supercritical Fluids Processing of Recombinant Human Growth Hormone
Drug Development and Industrial Pharmacy, 2005The aim of the study was to investigate the feasibility of precipitating recombinant human growth hormone (hGH) from aqueous solutions using conventional and modified techniques of solution-enhanced dispersion (SEDS) by supercritical fluids. The study investigated the effect on hGH stability of adding isopropanol either as a cosolvent with the original
Sitaram P, Velega, Johan, Carlfors
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Recombinant Human Growth Hormone for Children With Renal Failure
Advances in Renal Replacement Therapy, 1996The pathogenesis of growth retardation in children with chronic renal failure (CRF) is clearly multifactorial. A major breakthrough in the understanding of the pathogenesis of uremic growth failure was achieved only recently by a more detailed analysis of the growth hormone (GH)/insulinlike growth factor (IGF) axis.
B, Tönshoff, R N, Fine
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Safety of High Doses of Recombinant Human Growth Hormone
Hormone Research in Paediatrics, 1998Recombinant human growth hormone (r-hGH) is given as substitution therapy to growth hormone-deficient children at 0.01–0.025 mg/kg/day. Higher doses are used for short stature due to Turner’s syndrome and for idiopathic short stature (approximately 0.05 mg/kg/day).
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Recombinant human growth hormone: old and novel uses
The American Journal of Medicine, 1998Recent studies of the growth hormone insulinlike growth factor I (IGFI) axis suggest that these hormones are involved in several physiologic processes, in addition to growth. Thus, several lines of evidence indicate an increasingly important role for recombinant human growth hormone as a part of the modern therapeutic armamentarium.
N A, Tritos, C S, Mantzoros
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Recombinant Human Growth Hormone
BioDrugs, 2008The role of hormonal and metabolic alterations in HIV-associated lipodystrophy syndrome is not yet clear. In patients with HIV-1 undergoing antiretroviral treatment, lipodystrophy is associated with peripheral fat wasting and central adiposity, dyslipidemia, insulin resistance, and increased intramuscular fat accumulation. In HIV lipodystrophy, changes
S. Benedini +3 more
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Crystallization of Authentic Recombinant Human Growth Hormone
Nature Biotechnology, 1987Large single crystals of natural–sequence recombinant human growth hormone (r–hGH) have been grown from a medium containing polyethylene glycol and a non–ionic detergent, β–octyl glucoside. The identity of the crystals was confirmed by gel electrophoresis and anion exchange chromatography.
Noel D. Jones +3 more
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Clinical Experience with Authentic Recombinant Human Growth Hormone
Acta Paediatrica, 1986ABSTRACT. Studies of authentic recombinant human growth hormone (rhGH) began very recently in Germany. In this study, one group of patients with hGH deficiency is naïve (no previous hGH treatment), and the second group has been treated with pituitary hGH.
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