Results 191 to 200 of about 12,905,954 (250)

Multisystem developmental abnormalities and insulin resistance in ADTKD‐HNF1B with the p.E105K variant: A clinical conundrum

Diabetic Medicine, EarlyView.
Abstract Aims HNF1B variants cause autosomal dominant tubulointerstitial kidney disease (ADTKD‐HNF1B), but the phenotypic spectrum of variants of uncertain significance (VUS) remains incompletely defined. We aimed to characterise the multisystem phenotype associated with the HNF1B p.E105K variant and to examine the mechanism underlying insulin ...
YunZe Wang, KangChun Xu, PengFei Liu, Bin Wang, Yan Yang, ShanZhai Wei   +5 more
wiley   +1 more source

New insights into β‐cell vulnerability in type 1 diabetes—Lessons from nature

Diabetic Medicine, EarlyView.
Abstract Type 1 diabetes results from an autoimmune‐mediated destruction of pancreatic β‐cells, yet considerable heterogeneity exists regarding disease onset, progression and severity. Emerging evidence suggests that this variability reflects not only differences in immune responses, but also differences in the architecture and immune landscape of the ...
Kathryn Murrall, Teifion Luckett, Christiana Lekka, Stephanie L. Hunter, Sylvie Agnello, Peter Ferris, Emma Haxton, Christine S. Flaxman, Abirami Kannan, Xinpeng Dun, Sarah J. Richardson   +10 more
wiley   +1 more source

Dental resin composites generate microparticles and impact on gingival keratinocytes—In vitro study

European Journal of Oral Sciences, EarlyView.
Abstract Along with our increased understanding of the spread of microplastic pollution, the awareness of microparticle release from medical and dental materials has increased. Still, their effects on human health are largely unknown. As the use of resin composite materials in dentistry continues to increase, it is essential to understand the formation
Ella Pullinen, Saara V. Sirkiä, Johan Nyman, Pekka K. Vallittu, Vuokko Loimaranta   +4 more
wiley   +1 more source

Clinical comparison of mouthrinse and orodispersible film containing cystatins and a statherin‐derived peptide against initial dental erosion

European Journal of Oral Sciences, EarlyView.
Abstract This randomized crossover in vivo study compared the anti‐erosive efficacy of solution and orodispersible film (ODF) formulations containing three cystatins (CaneCPI‐5, MaquiCPI‐3, and CsinCPI‐2) combined with a statherin‐derived peptide (StN15pSpS).
Marília Afonso Rabelo Buzalaf, Even Akemi Taira, Gustavo Cassalate da Silva, Mariana Miranda de Brito, Talita Mendes Oliveira Ventura, Flávio Henrique‐Silva, João Guilherme Medeiros, Thiago Saads Carvalho, Andrea Soares da Costa Fuentes, Karina Fan, Reinaldo Marchetto, Adrian Lussi, Vinícius Taioqui Pelá   +12 more
wiley   +1 more source

Tankyrase‐2 regulates adipocyte differentiation through AMPK/mTOR signaling

The FEBS Journal, EarlyView.
Tankyrase 2 (TNKS2), a PARP family member, underpins adipocyte differentiation. TNKS2 controls LKB1 protein level, and consequently, the activity of the mTOR/AMPK system and adipocyte differentiation through a layered process. Pharmacological inhibition of TNKS2 leaves other PARPs and DNA repair active and therefore represents a novel target in ...
Boglarka Rauch, Gyula Ujlaki, Szilard Poliska, Nakayi Murahwa, Patrik Kovacs, Aladar Pettko‐Szandtner, Karen Uray, Peter Bai   +7 more
wiley   +1 more source

GSK3α‐mediated regulation of the RNA demethylase fat mass and obesity‐associated protein (FTO) during murine spermatogenesis

The FEBS Journal, EarlyView.
FTO regulates mRNA stability and translational efficiency through its m6A‐demethylation activity. GSK3 functions as an upstream regulator of FTO, leading to its inhibition via phosphorylation. In male germ cells, FTO activity is kept in check by GSK3α.
Neha Choudhari, Budheswar Dehury, Rounak Roy, Radhakrishnan Periyasamy, Indrashis Bhattacharya, Mahesh Sahare, Srinivasan Vijayraghavan, Souvik Dey   +7 more
wiley   +1 more source

From productive coupling to catalytic commitment: An evolutionarily tuned interdomain connector in Leishmania Aha1 orchestrates Hsp90 activation

The FEBS Journal, EarlyView.
LbAha1 activates LbHsp90 through a multistep mechanism in which productive N‐domain docking precedes ATP‐driven rearrangement and linker ordering. The LbAha1 linker transitions from a flexible to helical state, stabilizing an asymmetric, catalytically competent closed complex.
Paulo Roberto Dores‐Silva, Thiago Vargas Seraphim, Karine Minari, Izabella Rodrigues Fonseca da Silva, Winston Pinheiro Claro Gomes, Leijiane Figueira de Sousa, Arthur Moraes Franco da Rocha, Leandro Ramos Souza Barbosa, Jeremiah Stanson Joseph, Júlio César Borges   +9 more
wiley   +1 more source

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Recombinant human growth hormone.

Clinics in endocrinology and metabolism, 1986
All batches of Met-hGH examined stimulated statural growth to approximately the same extent. The growth rates measured partly exceeded the results obtained in previous studies with pituitary preparations in the same dosage. Under treatment with SI, i.e.
L M, Fryklund, J R, Bierich, M B, Ranke
openaire   +2 more sources

NAEVOCYTE TRIGGERING BY RECOMBINANT HUMAN GROWTH HORMONE

The Journal of Pathology, 1996
The influence of growth hormone and insulin-like growth factor I on human melanocytes is being increasingly recognized. Clinical evidence has shown that when recombinant human growth hormone (hGH) is administered to children of short stature, the growth of melanocytic naevi is boosted. This study was conducted on 56 hGH-triggered naevi and nine similar
Pierard, Gérald, Pierard-Franchimont, Claudine, Nikkels, Arjen, Tassoudji, Nazli, Arrese Estrada, Jorge, Bourguignon, Jean-Pierre   +5 more
openaire   +3 more sources

Recombinant human growth hormone and Gitelman's syndrome

American Journal of Kidney Diseases, 1999
Gitelman's syndrome is a primary renal tubular disorder with hypokalemic metabolic alkalosis, hypocalciuria, and magnesium deficiency. Short stature is one of clinical manifestations in children. The pathogenesis of short stature in Gitelman's syndrome is not known.
C W, Ko, J H, Koo
openaire   +2 more sources