Results 51 to 60 of about 12,905,954 (250)

Hyperinsulinemic Hypoglycemia and Growth Hormone Deficiency Secondary to 20p11 Deletion

Case Reports in Endocrinology, 2023
Hypoglycemia is concerning for neurological complications in infants and children. Determining the cause of hypoglycemia is essential in providing appropriate treatment.
Erica Wee, John Herriges, Kavitha Dileepan, Sarah L. Tsai, Joseph T. Alaimo, Emily Paprocki   +5 more
doaj   +1 more source

Reduced Effectiveness and Comparable Safety in Biweekly vs. Weekly PEGylated Recombinant Human Growth Hormone for Children With Growth Hormone Deficiency: A Phase IV Non-Inferiority Threshold Targeted Trial

Frontiers in Endocrinology, 2021
ContextLong-acting recombinant human growth hormone (rhGH) has transformed growth hormone deficiency (GHD) treatment. However, the possibility and rationality for flexible time regimen are pending.ObjectiveWe studied the efficacy of biweekly versus ...
Chengjun Sun, Biao Lu, Yu Liu, Yaqin Zhang, Haiyan Wei, Xu Hu, Pei Hu, Qian Zhao, Yanling Liu, Kan Ye, Kan Wang, Zaiyan Gu, Zheng Liu, Jin Ye, Hongxiao Zhang, Hong Zhu, Zhihong Jiang, Yanjie Liu, Naijun Wan, Chengming Yan, Jianying Yin, Lirong Ying, Feng Huang, Qingjin Yin, Li Xi, Feihong Luo, Ruoqian Cheng   +26 more
doaj   +1 more source

Efficacy of needle‐free administration of recombinant human growth hormone in adults with growth hormone deficiency [PDF]

British Journal of Clinical Pharmacology, 2006
AimNeedle‐free administration of recombinant human growth hormone (rhGH) is effective in the treatment of growth hormone deficiency (GHD) in children, but has not been studied in adult patients. Therefore, we evaluated the efficacy of needle‐free administration of rhGH in adults with GHD.MethodsInsulin‐like growth factor‐I (IGF‐I) concentrations were ...
Pereira, Alberto M., van der Klaauw, Agatha A., Koppeschaar, Hans P. F., Smit, Jan W. A., van Thiel, Sjoerd W., van Doorn, Jaap, Biermasz, Nienke R., Roelfsema, Ferdinand, Romijn, Johannes A.   +8 more
openaire   +3 more sources

Loss of LCN2 Function Ameliorates Glucocorticoid‐Induced Muscle Atrophy via Remodeling the Extracellular Matrix

Advanced Science, EarlyView.
Glucocorticoids transcriptionally activate LCN2 expression via GR nuclear translocation. Secreted LCN2 binds MMP9 to degrade skeletal muscle ECM collagen, blocks integrin‐mediated mechanotransduction, bidirectionally disrupts muscle protein homeostasis, and reveals a novel target for steroid‐induced muscle atrophy.
Hongwei Shi, Xiaojing Hao, Yi Yan, Fengyang Li, Yaru Zhang, Zixin Li, Wenjuan Xie, Jiayin Lu, Xiaomao Luo, Yanjun Dong, Haidong Wang, Juan Wang   +11 more
wiley   +1 more source

Influence of pH on recombinant human growth hormone production by Pichia pastoris

, 2010
BACKGROUND: Effect of pH on recombinant human growth hormone (rhGH) production by Pichia pastoris hGH-Mut(+) was investigated at pH = 4.2, 5.0, 5.5, and 6 ...
Özdamar, T.H., Inankur, B., Inankur, Bahar, Taşpinar, H., Ozdamar, Tuncer H., Yilmaz, Remziye, Yılmaz, Remziye, Çalık, Pınar, Acik, Eda, Bayraktar, E., Şahin, M., Taspinar, Hatice, Çalik, P., Bayraktar, Eda, Soyaslan, Elif S., Açik, E., Sahin, Merve, ÇALIK, PINAR, Soyaslan, E.Ş.   +18 more
core   +1 more source

Growth Hormone Deficiency

, 2022
Short stature is a common reason for a child to visit the endocrinologist, and can be a variant of normal or secondary to an underlying pathologic cause. Pathologic causes include growth hormone deficiency (GHD), which can be congenital or acquired later.
Colleen O\u27Neill, Mariam Gangat, Colleen O'Neill, Sally Radovick   +3 more
core   +1 more source

SPARC Drives Podocyte Mitochondrial Damage and Ferroptosis in Diabetic Kidney Disease Following Klotho Deficiency

Advanced Science, EarlyView.
Klotho deficiency promotes podocyte mitochondrial dysfunction and ferroptosis through activation of the PKCα/CUX1/SPARC/TGFβ‐RII axis. SPARC emerges as a key mediator linking Klotho loss to podocyte injury in DKD and other kidney injury models, suggesting broader implications for CKD progression.
Qing Yang, Huimin Jiang, Chenyang Xiong, Xindi Zhou, Qinqin Tan, Han Xiao, Lan Qiu, Chun Gan, Yaxi Chen, Haiping Yang, Wei Jiang, Qiu Li   +11 more
wiley   +1 more source

Methanol feeding strategy design enhances recombinant human growth hormone production by Pichia pastoris

, 2016
BACKGROUND: The effects of designed methanol and co-substrate feeding strategies on fed-batch recombinant human growth hormone (rhGH) production by Pichia pastoris hGH-Mut(+) were ...
Özge Ata, Gunes, Hande, Boy, Erdem, Ata, Ozge, Gül H Zerze, Tunçer H Özdamar, Zerze, Gul H., Hande Güneş, Erdem Boy, Ozdamar, Tuncer H., Pınar Çalık, Çalık, Pınar, ÇALIK, PINAR   +12 more
core   +1 more source

Targeting the NR1D1–IGF2BP2–V‐ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis‐Induced Immunosuppression

Advanced Science, EarlyView.
Sepsis disrupts immune‐cell rhythms and weakens bacterial clearance. Biomimetic nanovesicles combining erythrocyte and inflammation‐activated macrophage membranes deliver siNR1D1 to dysfunctional macrophages, restoring the NR1D1–IGF2BP2–V‐ATPase pathway, circadian regulation, phagolysosomal acidification, and antimicrobial defense.
Lang Chen, Wenyi Lin, Lang Jiang, Xuehui Gao, Chenyan Yu, Jili Han, Zhenping Liu, Xuefeng Li, Mei He, Chang Li, Qilan Li, Chaoying Song, Jiqian Xu, You Shang   +13 more
wiley   +1 more source

Adult growth hormone deficiency: academic extravagance or real clinical entity for the internist?

Italian Journal of Medicine, 2013
The Growth Hormone (GH) continues to act lifelong: it has been described, in fact, an Adult Growth Hormone Deficiency (AGHD) syndrome, involving several organs and functions, whose clinical aspects greatly improve with the administration of human ...
Giovanni Scanelli, Luca Catapano, Beatrice Traverso, Claudia Aimoni   +3 more
doaj   +1 more source