Results 51 to 60 of about 12,361,119 (285)
Ten years' clinical experience with biosimilar human growth hormone: a review of efficacy data [PDF]
, 2017 In 2006, the European Medicines Agency (EMA) approved Omnitrope(®) as a biosimilar recombinant human growth hormone (rhGH), on the basis of comparable quality, safety, and efficacy to the reference medicine (Genotropin(®), Pfizer).
Zabransky, Markus +11 more
core +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Journal of International Medical ResearchLinear growth delay is common in children with systemic lupus erythematosus. There have been scattered reports of using recombinant human growth hormone in these children, but safety remains a major concern.
Fujuan Liu +8 more
doaj +1 more source
Optical Detection of Cellular Signals at Material Interfaces
Advanced Healthcare Materials, EarlyView.Emerging functional materials are transforming optical detection of cellular signals. This review highlights optical techniques that exploit the unique optical properties of diverse materials to detect and quantify cellular electrical, chemical, and mechanical signals, and discusses key opportunities and challenges.
Xuchen Ren +5 more
wiley +1 more source
Frontiers in Endocrinology, 2022 Jintrolong® is a long-acting PEGylated recombinant human growth hormone (PEG-rhGH) developed for weekly injection in patients with pediatric growth hormone deficiency (PGHD). Although PEG modification of therapeutic proteins is generally considered safe,
Wei Wu +15 more
doaj +1 more source
Advanced Science, EarlyView.Single‐cell longitudinal profiling reveals that androgen‐deprivation therapy induces a DPT+ fibroblast‐complement axis that suppresses macrophage inflammation and drives CD8+ T cell exhaustion in prostate cancer. Concurrently, resistant epithelial subpopulations persist and engage TSPAN1‐ and NRXN1‐mediated programs promoting CRPC and neuroendocrine ...
Yang Chen +19 more
wiley +1 more source
Health-Related Quality of Life of Young Adults Treated with Recombinant Human Growth Hormone during Childhood. [PDF]
, 2015 BACKGROUND Since recombinant human growth hormone (rhGH) became available in 1985, the spectrum of indications has broadened and the number of treated patients increased.
Dagmar l'Allemand +24 more
core +3 more sources
Advanced Science, EarlyView.This study reveals that NF‐κB1‐driven TRAIP upregulation in ALD correlates with disease severity. Mechanistically, TRAIP directly binds β‐catenin via its CC domain and promotes its K48‐linked ubiquitination and degradation, which is independent of the GSK3β/β‐TrCP pathway.
Zhan Wu +13 more
wiley +1 more source
The Korean herbal formulation Yukmijihwangtang stimulates longitudinal bone growth in animal models
BMC Complementary and Alternative Medicine, 2017 Background Yukmijihwangtang (YJT) is a traditional Korean medicine that has been used to treat kidney-yin deficiency symptoms such as dizziness and tinnitus.
Sung-Min Cho +6 more
doaj +1 more source
Osteosarcoma associated with diamond-blackfan anaemia: a case of a child receiving growth hormone therapy [PDF]
, 2004 Purpose: Diamond–Blackfan anaemia (DBA) is a rare pure congenital red cell aplasia, usually presenting in infancy or early childhood. The literature suggests a predisposition to haemopoietic malignancy but in addition solid tumours have been reported ...
Briggs, TW +4 more
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