Results 221 to 230 of about 1,327,803 (301)

A novel HVEM-Fc recombinant protein for lung cancer immunotherapy. [PDF]

J Exp Clin Cancer Res
Yao Y, Li B, Wang J, Chen C, Gao W, Li C.   +5 more
europepmc   +1 more source

Potent Liver‐Tropic mRNA Lipid Nanoparticles: ApoE‐Mediated Delivery Through a Low‐Density Lipoprotein Receptor Independent Uptake Mechanism

Advanced Materials, EarlyView.
Helper and ionizable lipids play a crucial role in determining ApoE binding and subsequent liver tropism and LDLR‐mediated uptake. Ionizable lipids primarily govern the LDLR‐independent uptake pathway. This complementary interplay between lipid components ultimately governs LNP delivery performance and therapeutic efficacy in the liver.
Ashish Sarode, Christian Ortiz, Tadeh Derstepanian, Natalia Vargas‐Montoya, Priyal Patel, Nikita Khadse, Saikat Manna, Ryan Landis, Joseph Skaleski, Lianne Boeglin, Hongfeng Deng, Anusha Dias, Hong Wang, Debora Barreiros Petropolis, Barak Yahalom, Shrirang Karve, Frank DeRosa   +16 more
wiley   +1 more source

Advancing recombinant protein expression in Komagataella phaffii: opportunities and challenges. [PDF]

FEMS Yeast Res
Lv W, Cai M.
europepmc   +1 more source

Directed Functionalization of Recombinant Spider Silk Nonwoven Membranes with Antibodies Using Non‐Canonical Amino Acids

Advanced Materials, EarlyView.
A recombinant spider silk protein was functionalized by incorporating genetically encoded bio‐orthogonal reactive azido‐groups. The azido‐functionalized proteins were produced in a scalable biotechnological process, and particles, films, as well as nanofibers were established as anchorage for fully functional antibodies via site‐specific bio‐orthogonal
Claudia Lacombe, Charlotte Leonhardt, Martin Humenik, Birgit Wiltschi, Thomas Scheibel   +4 more
wiley   +1 more source

Effect of recombinant protein production and release on microalgal fitness and the impact of environmental conditions for localized therapeutic delivery. [PDF]

J Biol Eng
Carvajal F, Vargas-Torres V, Becerra D, González-Quezada N, Egaña JT.   +4 more
europepmc   +1 more source

Mistletoe‐ and Mussel‐Inspired Fabrication of Hierarchically Structured Protein‐Cellulose Scaffolds From Biomolecular Condensates

Advanced Materials, EarlyView.
Merging materials processing tricks inspired by mussel and mistletoe fiber fabrication, solutions of cationic mussel byssus proteins were mixed with modified anionic nanocrystalline cellulose, producing distinctive core‐shell condensates. Simple processing of condensate suspensions using freeze‐drying produced hierarchically structured porous protein ...
Hamideh R. Alanagh, Seyed Mohammad Amin Ojagh, Arman Jafari, Xinyu Zhan, Tara Sprules, Alexandre Poulhazan, Houman Savoji, Adam G. Hendricks, Theo G.M. van de Ven, Matthew J. Harrington   +9 more
wiley   +1 more source

Analysis of antibody markers as immune correlates of risk of severe COVID-19 in the PREVENT-19 efficacy trial of the NVX-CoV2373 recombinant protein vaccine. [PDF]

Clin Infect Dis
Fong Y, Huang Y, Huang Y, Woo W, McGarry A, Áñez G, Dunkle LM, Cho I, Houchens CR, Martins K, Jayashankar L, Castellino F, Petropoulos CJ, Leith A, Haugaard D, Webb W, Lu Y, Yu C, Carpp LN, Randhawa AK, Andrasik MP, Kublin JG, Hutter J, Keshtkar-Jahromi M, Beresnev TH, Rodriguez CA, Tapia M, Turley CB, Zorrilla CD, Cohen SH, Kline SE, Barranco E, Corey L, Neuzil KM, Follmann D, Ake JA, Gay CL, Kotloff KL, Jones T, Koup RA, Donis RO, Gilbert PB.   +41 more
europepmc   +1 more source

Cancer Cells Traverse Faster in Confined Space by Modifying Vimentin filaments With Nuclear Deformation and Promoting the Growth of Desired Tumor Spheroids

Advanced Materials Interfaces, EarlyView.
This study demonstrates how the Vimentin intermediate (VIM) filaments distribution/density regulates the attainment of different migration modes through cytoskeleton rearrangement and controls the nuclear morphology in migrating cells under physical confinement, which facilitates the faster traversing of those cells and the growth of post‐migration ...
Md Kowsar Alam, Jiao Zhai, Heng Zou, Yu Chen, Michael Yang   +4 more
wiley   +1 more source

Enhancing recombinant protein production through Cre-loxP mediated chromosomal rearrangement evolution in Kluyveromyces marxianus. [PDF]

Commun Biol
Ren H, Zou Q, Song K, Yu Y, Zhou J, Mo W, Lu H.   +6 more
europepmc   +1 more source

The Vegan Villain Sets Out to The End of Summer: Functionalized Coatings as Biohybrid UV‐Sensors

Advanced Materials Interfaces, EarlyView.
This study introduces biohybrid coatings incorporating E. coli biomass expressing photoconvertible fluorescent proteins as UV‐A responsive elements. Upon irradiation at 400 nm, the coatings exhibit an irreversible fluorescence shift from green to red within 15 min. Notably, the photoconversion capability is retained after >1 year of storage.
Amelie Skopp, Matea Marosevic, Broder Rühmann, Volker Sieber   +3 more
wiley   +1 more source