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Recombination genes and proteins
Current Opinion in Genetics & Development, 1994The recombination of DNA takes place by a multistep process involving numerous gene products. In the past year, studies using bacterial proteins have led to a number of significant advances in our understanding of the enzymes of recombination and of the reactions that they catalyze.
H J, Dunderdale, S C, West
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Recombination Proteins in Yeast
Annual Review of Genetics, 2004▪ Abstract The process of homologous recombination promotes error-free repair of double-strand breaks and is essential for meiosis. Central to the process of homologous recombination are the RAD52 group genes (RAD50, RAD51, RAD52, RAD54, RDH54/TID1, RAD55, RAD57, RAD59, MRE11, and XRS2), most of which were identified by their requirement for the ...
Berit Olsen, Krogh +1 more
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Recombinant proteins for therapy
Trends in Pharmacological Sciences, 1996Recombinant therapeutic proteins have become increasingly important over the past ten years. Numerous products derived from 20 different proteins are already on the market. In this review Peter Buckel discusses the issues surrounding the use of recombinant proteins as therapeutic agents.
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Recombinant Protein Production in Yeasts
Molecular Biotechnology, 2005Recombinant DNA (rDNA) technologies (genetic, protein, and metabolic engineering) allow the production of a wide range of peptides, proteins, and biochemicals from naturally nonproducing cells. These technologies, now approx 25 yr old, have become one of the most important technologies developed in the twentieth century.
PORRO, DANILO +3 more
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Recombinant Protein Production in Yeasts
2011Recombinant protein production is a multibillion-dollar market. The development of a new product begins with the choice of a production host. While one single perfect host for every protein does not exist, several expression systems ranging from bacterial hosts to mammalian cells have been established.
Mattanovich, D +5 more
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Recombinant Protein Production in Yeasts
2004Recombinant DNA (rDNA) technologies (genetic, protein, and metabolic engineering) allow the production of a wide range of peptides, proteins, and biochemicals from naturally nonproducing cells. This technology, now approx 25 yr old, is becoming one of the most important technologies developed in the 20th century.
Porro, D, Mattanovich, D
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Insights on the Formulation of Recombinant Proteins
2019Recombinant proteins are large and complex molecules, whose therapeutic activity highly depends on their structure. Formulation of biopharmaceuticals aims at stabilizing protein conformation, promoting its efficacy, and preventing safety concerns, such as immunogenicity. Currently, the rational design of formulations is possible due to the availability
Ribeiro, Rita +4 more
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Overview of the Characterization of Recombinant Proteins
Current Protocols in Protein Science, 1995AbstractThis overview provides guidelines for the characterization of recombinantly expressed proteins (e.g., verifying primary structure and appropriate post‐translational modifications), along with methodologies for characterizing the proteins according to size, X‐ray structure, absorbance, biological activity, and subunit structure.
Denslow, Nancy D. +2 more
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Overproduction of recombinant proteins in plants
Plant Science, 2012Recombinant protein production in microbial hosts and animal cell cultures has revolutionized the pharmaceutical and industrial enzyme industries. Plants as alternative hosts for the production of recombinant proteins are being actively pursued, taking advantage of their unique characteristics.
Erin, Egelkrout +2 more
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Capillary electrophoresis of recombinant proteins
Journal of Chromatography B: Biomedical Sciences and Applications, 1997Many naturally occurring proteins which are used therapeutically have been cloned and expressed in large quantities in bacterial, yeast or mammalian systems. Purification of these proteins by column chromatography generates high purity products with low levels of host protein contaminants.
K A, Denton, S A, Tate
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