Results 121 to 130 of about 508,275 (214)

Stramenopile microalgae as "green biofactories" for recombinant protein production. [PDF]

World J Microbiol Biotechnol, 2021
de Grahl I, Reumann S.
europepmc   +1 more source

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

Escherichia coli BL21 adapts its central carbon metabolism to recombinant protein production and oxygen limitation. [PDF]

Microb Cell Fact
Rane DV, Haaland KL, Refsnes Å, Skuggedal H, Øverbø SR, Bruheim P, García-Calvo L.   +6 more
europepmc   +1 more source

Fusion Tag Design Influences Soluble Recombinant Protein Production in Escherichia coli. [PDF]

Int J Mol Sci, 2022
Köppl C, Lingg N, Fischer A, Kröß C, Loibl J, Buchinger W, Schneider R, Jungbauer A, Striedner G, Cserjan-Puschmann M.   +9 more
europepmc   +1 more source

Adipocyte‐Derived Leptolin Enhances Energy Expenditure and Prevents Obesity

Advanced Science, EarlyView.
We identified a novel adipokine, which we named leptolin. In humans, leptolin levels in white adipose tissue were positively correlated with exercise and negatively associated with body mass index. We observed elevated leptolin in serum from athletes and lower leptolin in serum from obese individuals.
Jiarui Liu, Bingwei Wang, Zhijie Su, Xiaoxv Han, Miao He, Yun Zhao, Yujia Hou, Daotong Li, Weiguang Zhang, Lihua Qin, Ke Wang, Yanchun Li, Yi Yan, Siwang Yu, Xiaoshuai Huang, Tairan Yuwen, Jianyuan Luo, Ruimao Zheng   +17 more
wiley   +1 more source

Enhancing CHO cell recombinant protein production using a perfusion-directed host evolution approach. [PDF]

Biotechnol Prog
Amaya P, Mistry RK, Sou S, Hess S, Khanal B, Schaeffer Z, Zhu J, Chakrabarti L.   +7 more
europepmc   +1 more source

The Effect of Recombinant Protein Production in Lactococcus lactis Transcriptome and Proteome. [PDF]

Microorganisms, 2022
Monteiro GA, Duarte SOD.
europepmc   +1 more source

Agnuside Stabilizes the Complex I Assembly Factor NDUFAF6 to Reinforce Mitochondrial Efficiency and Thermogenic Responsiveness

Advanced Science, EarlyView.
ABSTRACT Brown and beige adipocytes dissipate energy as heat, yet effective strategies to enhance their mitochondrial efficiency remain limited. Here, we identify Agnuside (AGN) as a selective stabilizer of the complex I assembly factor NDUFAF6. AGN directly binds cytosolic NDUFAF6, suppresses its ubiquitination, prolongs its half‐life, and facilitates
Qingwen Zhao, Li Xie, Qianzhuo Wang, Shuying Dai, Bei Li, Yingjuan Zhang, Zhe Sun, Yue Gao   +7 more
wiley   +1 more source

Engineering the green algae Chlamydomonas incerta for recombinant protein production. [PDF]

PLoS One
Kang K, Santo ÉDE, Diaz CJ, Oliver A, Saxton L, May L, Mayfield S, Molino JVD.   +7 more
europepmc   +1 more source

Advances in Cell Engineering of the Komagataella phaffii Platform for Recombinant Protein Production. [PDF]

Metabolites, 2022
Bustos C, Quezada J, Veas R, Altamirano C, Braun-Galleani S, Fickers P, Berrios J.   +6 more
europepmc   +1 more source