Results 61 to 70 of about 575,728 (172)

Comparison of efficacy of Diaskintest®, a skin test with a recombinant tuberculosis allergen, used for 10 years and Mantoux tuberculin sensitivity test used for 110 years

open access: yesБиопрепараты: Профилактика, диагностика, лечение, 2018
The article compares results reported in national and foreign literature concerning tuberculosis detection by various in vivo (skin tests such as the Mantoux test and Diaskintest® (a skin test with a recombinant tuberculosis allergen)) and in vitro ...
L. V. Slogotskaya   +3 more
doaj  

Design of a Novel Peptide‐Based Vaccine Targeting Streptococcus mutans SpaP Antigen for Dental Caries Prevention

open access: yesInternational Journal of Dentistry, Volume 2026, Issue 1, 2026.
Objective Dental caries is a widespread oral health issue affecting both children and adults. Streptococcus mutans (S. mutans) is a key bacterium responsible for its development. The Antigen I/II (Ag I/II; SpaP) protein of S. mutans is a promising target for a caries vaccine.
Fazilat Khademi   +3 more
wiley   +1 more source

Do successful tuberculosis vaccines need to be immunoregulatory rather than merely Th1-boosting? [PDF]

open access: yes, 2005
Tuberculosis vaccine candidates are entering clinical studies in areas where BCG fails. This is a high-risk strategy. We suggest that geographical variation in the efficacy of BCG is related to the presence in developing countries of a cross-reactive ...
Rook, GAW, Dheda, K, Zumla, A
core  

Construction, stability and immunogenicity of recombinant BCG expressing HIV-1 subtype C gag under the control of MtrA promoter, with or without the leader sequences [PDF]

open access: yes, 2011
This study aimed to compare recombinant mycobacteria expressing HIV-1 gag under the control of different promoters and leader sequences. This was done to determine whether the genetic stability of the recombinant mycobacteria could be improved by ...
Lebeko, Maribanyana R
core   +1 more source

Clinical and Epidemic Characteristics in Children with Newly Diagnosed Post-Tuberculosis Changes

open access: yesТуберкулез и болезни лёгких
The objective: to study clinical and epidemic characteristics in children with newly diagnosed post-tuberculosis changes.Subjects and Methods. Medical records of 78 children with newly diagnosed post-tuberculosis changes were analyzed; all those children
N. E. Khoroshilova   +2 more
doaj   +1 more source

EFFICIENCY OF USING TUBERCULOUS RECOMBINANT ALLERGEN FOR SCREENING FOR TUBERCULOUS INFECTION IN CHILDREN AND ADOLESCENTS IN STAVROPOL KRAY

open access: yesТуберкулез и болезни лёгких, 2016
Goal of the study: to define efficiency ofthe screening with the tuberculous recombinant allergen (TRA) in children and adolescents with the purpose of tuberculosis detection and defining the groups of the advanced risk of developing tuberculosis ...
O. D. Baronova   +3 more
doaj   +1 more source

Polysaccharide Adjuvants as Innate Immune Trainers: Bridging Pattern Recognition Receptor (PRR) Activation and Metabolic Reprogramming for Synthetic Vaccine Design

open access: yesAdvanced Science, Volume 12, Issue 48, December 29, 2025.
Polysaccharides modulate immune responses by engaging pattern recognition receptors (PRRs) to induce T‐cell activation. In vaccine design, their particle size critically influences lymph node targeting and activation mechanisms. By engineering structural complexity and multivalent PRR engagement, polysaccharides enable precise modulation of immune ...
Jeong Hyun Moon   +8 more
wiley   +1 more source

ACTUAL ISSUES OF TUBERCULOSIS IN ADOLESCENTS EXPOSED TO TUBERCULOSIS INFECTION

open access: yesТуберкулез и болезни лёгких, 2018
The article characterizes respiratory tuberculosis in adolescents exposed to tuberculous infection. Exposure to tuberculosis in the family or when contacting close relatives makes the biggest contribution into development of the disease unless the ...
E. S. Ovsyankina   +4 more
doaj   +1 more source

Label‐Free Electrochemical Impedance Spectroscopy for Biosensing: Evolving Interfaces and Mechanistic Insights

open access: yesSmall Science, Volume 5, Issue 12, December 2025.
Electrochemical impedance spectroscopy‐based label‐free biosensors offer rapid, direct, and sensitive analyte detection by measuring impedance changes in real time. Innovations in nanoengineered electrode surfaces and biorecognition elements have enhanced their performance facilitating point‐of‐care applications, despite ongoing challenges in ...
Nandhinee Radha Shanmugam   +4 more
wiley   +1 more source

The Place of Surgery in the Diagnosis of Genitourinary Tuberculosis

open access: yesТуберкулез и болезни лёгких
The objective: to determine the place of surgery in the diagnosis of genitourinary tuberculosis (GUTB).Subjects and Methods. We retrospectively analyzed the surgical protocols and medical records of 174 patients who underwent surgery in Extrapulmonary ...
M. P. Korchagin, M. A. Prokopovich
doaj   +1 more source

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