Results 1 to 10 of about 236,590 (143)

Effectiveness of a Bivalent Recombinant Vaccine on the Production of Neutralizing Antibodies Against BoNT/C, BoNT/D, BoNT/CD e BoNT/DC in Bovines [PDF]

Vaccines
Background/Objectives. Bovine botulism, although relatively rare, presents significant economic losses due to high mortality rates and restrictions on livestock product trade.
Ilenia Drigo, Luca Zandonà, Elena Tonon, Katia Capello, Luca Bano   +4 more
doaj   +2 more sources

Fast antibody responses by immuno-targeting and nanotechnology strategies versus HBsAg vaccine [PDF]

Iranian Journal of Basic Medical Sciences, 2021
Objective(s): Though immunization with HBsAg has been routine since the 1980s, it has numerous limitations such as low or none humoral immune responses. Today, nanotechnology is used in vaccinology to achieve higher potency.
Mahsa Rezaei, Seyed Nezamedin Hosseini, Ramazan Ali Khavari-Nejad, Farhood Najafi, Mehdi Mahdavi   +4 more
doaj   +1 more source

Development of an Adeno-Associated Virus-Vectored SARS-CoV-2 Vaccine and Its Immunogenicity in Mice

Frontiers in Cellular and Infection Microbiology, 2022
Owing to the outbreak of the novel coronavirus (SARS-CoV-2) worldwide at the end of 2019, the development of a SARS-CoV-2 vaccine became an urgent need.
Xi Qin, Shanhu Li, Xiang Li, Dening Pei, Yu Liu, Youxue Ding, Lan Liu, Hua Bi, Xinchang Shi, Ying Guo, Enyue Fang, Fang Huang, Lei Yu, Liuqiang Zhu, Yifang An, C. Alexander Valencia, Yuhua Li, Biao Dong, Yong Zhou   +18 more
doaj   +1 more source

Potentiation of the therapeutic effect of intravesical BCG through synthetic and biogenic selenium nanoparticles in a nitrosamine-induced bladder cancer mouse model

Advances in Cancer Biology - Metastasis, 2022
Introduction: Intravesical Mycobacterium Bovis bacillus Calmette-Guérin (BCG) therapy for non-muscle invasive bladder cancer has been successfully applied to prevent metastasis and disease progression.
Ramak Ajideh, Mohammad Reza Pourmand, Mohammad Ali Faramarzi, Zargham Sepehrizadeh, Gholamreza Pourmand, Seyed Mehdi Hassanzadeh, Mehdi Mahdavi, Ahmad Reza Shahverdi, Mohammad Hossein Yazdi   +8 more
doaj   +1 more source

Construction of a recombinant avipoxvirus expressing the env gene of Zika virus as a novel putative preventive vaccine

Virology Journal, 2021
Background Zika virus (ZIKV) has been declared a public health emergency that requires development of an effective vaccine, as it might represent an international threat. Methods Here, two novel DNA-based (pVAXzenv) and fowlpox-based (FPzenv) recombinant
Carlo Zanotto, Francesca Paolini, Antonia Radaelli, Carlo De Giuli Morghen   +3 more
doaj   +1 more source

Generation and evaluation of specific activity and authenticity of recombinant vaccine designed preventing against Pseudomonas aeruginosa

Инфекция и иммунитет, 2021
The aim of the study was to obtain and characterize a recombinant vaccine for the immunoprophylaxis of infections caused by Pseudomonas aeruginosa. A set of two highly immunogenic P. aeruginosa recombinant proteins was used to create related vaccine. The
A. A. Kaloshin, E. M. Zimina, E. O. Kalinichenko, N. A. Mihailova   +3 more
doaj   +1 more source

Safety and Immunogenicity of a Recombinant Tetanus Vaccine in Healthy Adults in China: A Randomized, Double‐Blind, Dose Escalation, Placebo‐ and Positive‐Controlled, Phase 1/2 Trial

Advanced Science, 2021
Tetanus is a fatal but vaccine‐preventable disease. The currently available tetanus vaccines are tetanus toxoid (TT)‐based. Although these vaccines are generally effective, challenges in vaccine development and access remain.
Xiaowei Xu, Rui Yu, Lanlan Xiao, Jie Wang, Meihong Yu, Junjie Xu, Yajun Tan, Xiao Ma, Xiaoxin Wu, Jiangshan Lian, Kaizhou Huang, Xiaoxi Ouyang, Sheng Bi, Shipo Wu, Xiaoyan Wang, Jiandi Jin, Ling Yu, Huafen Zhang, Qi Wei, Jinfa Shi, Wei Chen, Lanjuan Li   +21 more
doaj   +1 more source

Comparison of Immune Responses Elicited by SARS-CoV-2 mRNA and Recombinant Protein Vaccine Candidates

Frontiers in Immunology, 2022
After the outbreak of COVID-19, billions of vaccines with different types have been administrated, including recombinant protein vaccines and mRNA vaccines.
Yixin Wu, Huicong Zhang, Liuxian Meng, Fusheng Li, Fusheng Li, Changyuan Yu   +5 more
doaj   +1 more source

Prevention and control of chicken coccidiosis construction of recombinant Lactococcus lactis expressing chicken IL-4 and IL-2 fusion protein and its immune synergistic effect on chicken coccidia live vaccine

Poultry Science, 2023
: Intestinal mucosa injury and loss of weight gain are unavoidable while using live vaccine strain to prevent chicken coccidiosis. In this study, recombinant Lactococcus lactis NZ3900/pNZ8149-IL-4-IL-2, expressing the fusion protein of chicken IL-4 and ...
Longlong Zheng, Li Zhang, Fan Tan, Chen Wang, Xiaoling Lv, Rui Bai, Nairui Huo, Mingxue Zheng   +7 more
doaj   +1 more source

Safety and Immunogenicity of a novel three-dose recombinant nanoparticle rabies G protein vaccine administered as simulated post exposure immunization: A randomized, comparator controlled, multicenter, phase III clinical study

Human Vaccines & Immunotherapeutics, 2021
Background Rabies vaccines are lifesaving in human post animal exposure. However, the compliance to the complete course of vaccine is found to be only 60%.
Ravish H S, Akash Khobragade, Durga Satapathy, Monica Gupta, Surendra Kumar, Vinay Bhomia, Ramasubramanian V, Maharshi Desai, Ashok Dilipkumar Agrawal   +8 more
doaj   +1 more source