Results 141 to 150 of about 131,465 (263)

Transcription factor Sp2: Molecular characterization and generation of Sp2 gene targeted mice [PDF]

, 2005
Summary The Sp family of transcription factors is characterised by its DNA-binding domain, an array of three conserved C2H2 zinc fingers. As a consequence of the conserved DNA binding motif, Sp members recognize GC (GGGGCGGGG) and GT (GGTGTGGGG) boxes
Baur, Frank, Renkawitz-Pohl, Renate (Prof. Dr.)   +1 more
core   +1 more source

A portable fluorescence-based recombinase polymerase amplification assay for the detection of mal secco disease by Plenodomus tracheiphilus

Crop Protection
In this ...
Ermes Ivan Rovetto, M. Garbelotto, Salvatore Moricca, Marcos Amato, F. La Spada, S. O. Cacciola   +5 more
semanticscholar   +1 more source

ZNF384‐Driven Fibulin‐1 Exacerbates Vascular Stiffness via TGF‐β/Smad3‐Mediated Senescence and Fibrosis

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
This article elucidates the regulatory molecular mechanisms of Fibulin‐1 (Fbln1) in vascular stiffness and explores potential therapeutic interventions. Zinc Finger Protein 384 (ZNF384) binds to the Fbln1 promoter, driving its expression. Fbln1 activates the TGF‐β/Smad3 axis, promoting vascular smooth muscle cell (VSMC) senescence and collagen ...
Dan Yan, Tianyi ji, Xiaolu Liang, Mandi Luo, Yi Huang, Pengcheng Luo, Zhen Yang, Le Zhang, Tao Li, Yong Ping Bai, Cuntai Zhang, Lei Ruan   +11 more
wiley   +1 more source

A portable device for nucleic acid quantification powered by sunlight, a flame or electricity. [PDF]

, 2018
A decentralized approach to diagnostics can decrease the time to treatment of infectious diseases in resource-limited settings. Yet most modern diagnostic tools require stable electricity and are not portable.
Cesarman, Ethel, Duru, Jens, Erickson, David, Gardner, Andrea, Kopparthy, Varun Lingaiah, Martin, Jeffrey, Maurer, Toby, Semeere, Aggrey, Snodgrass, Ryan   +8 more
core   +1 more source

RB loss contributes to aggressive tumor phenotypes in MYC-driven triple negative breast cancer [PDF]

, 2015
Triple negative breast cancer (TNBC) is characterized by multiple genetic events occurring in concert to drive pathogenic features of the disease. Here we interrogated the coordinate impact of p53, RB, and MYC in a genetic model of TNBC, in parallel with
Ertel, Adam, FORTINA, PAOLO, Franco, Jorge, Kathleen McClendon, A., Knudsen, Erik S, Witkiewicz, Agnieszka K.   +5 more
core   +1 more source

NOTCH3 CADASIL Variant Receptor Aggregation Requires NOTCH3 Wild‐Type Receptors: Identification of Highly Selective Inhibitors That Block the Process

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
CADASIL is the major cause of early‐onset stroke and cognitive dysfunction, including dementia. It is caused by mutations in the NOTCH3 receptor that result in the formation of protein aggregates in the small vessel walls of the brain. We demonstrated that NOTCH3 CADASIL variant receptor aggregation is strictly dependent on interactions with NOTCH3 ...
Haijiang Wang, Xinxin Liu, Gido Gravesteijn, Alessia Atella, Jin Liu, Julie W. Rutten, Peter ten Dijke, Manuel A. F. V. Gonçalves, Saskia A. J. Lesnik Oberstein, David A. Baker   +9 more
wiley   +1 more source

iLABMED: A Translational Medical Journal Embracing a New Era

iLABMED, EarlyView.
Tetsuya Asakawa, Yi‐Wei Tang, Hongzhou Lu   +2 more
wiley   +1 more source

Rapid Decentralized Prostate Cancer Risk Stratification by Portable Liquid Biopsy Analysis within a Clinical Biosensor Validation Framework

Advanced Science, Volume 13, Issue 13, 3 March 2026.
In this work, we showcased two significant scientific advances in (i) developing a portable biosensor technology for rapid decentralized prostate cancer urinary biomarker testing and reporting, with superior performance to current clinical testing practice; and (ii) proposing a clinical validation framework (for our biosensor development) which can be ...
Kevin M. Koo, Grant Phillips, Sriganesh Srihari, Áine Farrell, Binny Jaradi, Kira J. Fitzpatrick, John W. Yaxley, Hemamali Samaratunga, Paul N. Mainwaring, Ke‐lin Ru, Darren J. Korbie, Scott A. Tomlins, Matthew J. Roberts, Robert A. Gardiner, Matt Trau   +14 more
wiley   +1 more source

Targeting DNA‐LNPs to Endothelial Cells Improves Expression Magnitude, Duration, and Specificity

Advanced Science, Volume 13, Issue 14, 9 March 2026.
Attaching antibodies against endothelial cell surface proteins redirects the delivery and expression of DNA‐lipid nanoparticles to organs of interest. Our targeted nanoparticles enable organ‐selective DNA expression in the endothelium of the lungs, brain, or spleen, providing a therapeutic platform for dozens of endothelial‐centric diseases.
Nicolas Marzolini, Taylor V. Brysgel, Ryan J. Rahman, Eno‐Obong Essien, Saw Y. Nwe, Jichuan Wu, Aparajeeta Majumder, Manthan N. Patel, Sachchidanand Tiwari, Carolann L. Espy, Fengyi Dong, Sabrina A. Santos‐De León, Anit Shah, Vladimir V. Shuvaev, Elizabeth D. Hood, Liam S. Chase, Drew Weissman, Jeremy B. Katzen, David B. Frank, Mariko L. Bennett, Oscar A. Marcos‐Contreras, Jacob W. Myerson, Vladimir R. Muzykantov, Sahily Reyes‐Esteves, Jacob S. Brenner   +24 more
wiley   +1 more source

Development of real-time recombinase polymerase amplification assay for rapid and sensitive detection of canine parvovirus 2

BMC Veterinary Research, 2017
Background Canine parvovirus 2, a linear single-stranded DNA virus belonging to the genus Parvovirus within the family Parvoviridae, is a highly contagious pathogen of domestic dogs and several wild canidae species.
Yunyun Geng, Jianchang Wang, Libing Liu, Yan Lu, Ke Tan, Yan-Zhong Chang   +5 more
doaj   +1 more source