Results 1 to 10 of about 3,360,844 (180)

A high-resolution map of non-crossover events reveals impacts of genetic diversity on mammalian meiotic recombination

Nature Communications, 2018
During meiotic recombination, homologue-templated repair of programmed DNA double-strand breaks (DSBs) produces relatively few crossovers and many difficult-to-detect non-crossovers.
Ran Li, E. Bitoun, Nicolas Altemose, R. Davies, B. Davies, S. Myers   +5 more
semanticscholar   +1 more source

The genetic architecture of genome‐wide recombination rate variation in allopolyploid wheat revealed by nested association mapping

The Plant Journal, 2018
Summary Recombination affects the fate of alleles in populations by imposing constraints on the reshuffling of genetic information. Understanding the genetic basis of these constraints is critical for manipulating the recombination process to improve the
K. Jordan, Shichen Wang, Fei He, S. Chao, Y. Lun, E. Paux, P. Sourdille, J. Sherman, Alina Akhunova, N. Blake, M. Pumphrey, K. Glover, J. Dubcovsky, L. Talbert, E. Akhunov   +14 more
semanticscholar   +1 more source

Refined genetic maps reveal sexual dimorphism in human meiotic recombination at multiple scales

Nature Communications, 2017
In humans, males have lower recombination rates than females over the majority of the genome, but the opposite is usually true near the telomeres. These broad-scale differences have been known for decades, yet little is known about differences at the ...
Claude Bhérer, Christopher L. Campbell, A. Auton   +2 more
semanticscholar   +1 more source

Conserved Genetic Architecture Underlying Individual Recombination Rate Variation in a Wild Population of Soay Sheep (Ovis aries)

Genetics, 2016
Meiotic recombination breaks down linkage disequilibrium (LD) and forms new haplotypes, meaning that it is an important driver of diversity in eukaryotic genomes.
S. Johnston, C. Bérénos, J. Slate, J. Pemberton   +3 more
semanticscholar   +1 more source

Genetic Recombination Is Targeted towards Gene Promoter Regions in Dogs [PDF]

PLoS Genetics, 2013
The identification of the H3K4 trimethylase, PRDM9, as the gene responsible for recombination hotspot localization has provided considerable insight into the mechanisms by which recombination is initiated in mammals.
A. Auton, Ying Rui Li, J. Kidd, K. Oliveira, Julie Nadel, J. K. Holloway, J. J. Hayward, P. Cohen, J. Greally, Jun Wang, C. Bustamante, A. Boyko, Ian Henderson   +12 more
semanticscholar   +1 more source

Variation in Recombination Rate and Its Genetic Determinism in Sheep Populations

Genetics, 2017
Recombination is a complex biological process that results from a cascade of multiple events during meiosis. Understanding the genetic determinism of recombination can help to understand if and how these events are interacting.
M. Petit, J. Astruc, J. Sarry, L. Drouilhet, S. Fabre, Carole R Moreno, B. Servin   +6 more
semanticscholar   +1 more source

Pan-cancer landscape of homologous recombination deficiency

Nature Communications, 2020
Homologous recombination deficiency (HRD) results in impaired double strand break repair and is a frequent driver of tumorigenesis. Here, we develop a genome-wide mutational scar-based pan-cancer Classifier of HOmologous Recombination Deficiency (CHORD ...
Luan Nguyen, John W M Martens, Arne van Hoeck, E. Cuppen   +3 more
semanticscholar   +1 more source

The Genetic Architecture of Natural Variation in Recombination Rate in Drosophila melanogaster

PLoS Genetics, 2016
Meiotic recombination ensures proper chromosome segregation in many sexually reproducing organisms. Despite this crucial function, rates of recombination are highly variable within and between taxa, and the genetic basis of this variation remains poorly ...
C. Hunter, Wen Huang, T. Mackay, Nadia D Singh   +3 more
semanticscholar   +1 more source

The coronavirus proofreading exoribonuclease mediates extensive viral recombination

bioRxiv, 2020
Coronaviruses (CoVs) emerge as zoonoses and cause severe disease in humans, demonstrated by the SARS-CoV-2 (COVID-19) pandemic. RNA recombination is required during normal CoV replication for subgenomic mRNA (sgmRNA) synthesis and generates defective ...
J. Gribble, A. Pruijssers, Maria L. Agostini, J. Anderson-Daniels, J. Chappell, Xiaotao Lu, Laura J. Stevens, Andrew L. Routh, M. Denison   +8 more
semanticscholar   +1 more source

Cattle Sex-Specific Recombination and Genetic Control from a Large Pedigree Analysis

PLoS Genetics, 2015
Meiotic recombination is an essential biological process that generates genetic diversity and ensures proper segregation of chromosomes during meiosis. From a large USDA dairy cattle pedigree with over half a million genotyped animals, we extracted 186 ...
Li Ma, J. O’Connell, P. Vanraden, Botong Shen, A. Padhi, Chuanyu Sun, D. Bickhart, J. Cole, D. Null, G. Liu, Y. Da, G. Wiggans   +11 more
semanticscholar   +1 more source