Results 151 to 160 of about 229,253 (309)
Advanced Science, EarlyView.The Tuta absoluta salivary effector TaCRVP subverts tomato immunity by hijacking host catalase SlCAT2. Through a sophisticated dual mechanism, TaCRVP simultaneously promotes SlCAT2 tetramerization for activation and blocks its SlAdBiL‐mediated degradation for stabilization.
Jianquan Yan +9 more
wiley +1 more source
Report ... Presented to both Houses of Parliament by command of His Majesty.
, 1904 Chairman: Esher.At head of title: War Office (Reconstitution) Committee.Viscount Esher, chairman.Known as the "Esher Committee".(Cd.
Esher, Reginald Baliol Brett, Viscount, 1852-1930. +1 more
core
A Synthetic Platform for Antibody Junctional Diversification Beyond Natural Constraints
Advanced Science, EarlyView.ARESEC is a synthetic platform that reconstructs functional V(D)J recombination in HEK293T cells. By introducing RSS elements and co‐expressing RAG1/2 and TdT across all three antibody CDRs, it enables programmable junctional diversification and direct generation of high‐affinity variants targeting PD‐1/PD‐L1, overcoming the evolutionary constraints of
Wang Liu +3 more
wiley +1 more source
Advanced Science, EarlyView.Chemotherapy leverages tumor‐cell autophagy to reshape the colorectal cancer immune microenvironment. Autophagy degrades FBXW2 to promote C/EBPβ‐mediated TIMP‐2 transcription and MMP‐9 suppression, driving intra‐tumoral CD8+ T‐cell infiltration. Targeting MMP‐2/9 or restoring TIMP‐2 overcomes chemo‐resistance in autophagy‐deficient tumors. ABSTRACT The
Bing Cheng +12 more
wiley +1 more source
Reconstitution des prototypes de Poleni : cabestan
, 2014 Reconstitution par les étudiants de BTS Développement Bois lycée Elorn (Landerneau). Responsable projet : Alain Monot.
Céline Le Gall
core
Advanced Science, EarlyView.Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Shaocong Wang +10 more
wiley +1 more source
<i>In Vivo</i> Dynamics of Immunoregulatory Lymphocyte Reconstitution: A Seven-year Longitudinal Study of Sustained Remission in Class IV Lupus Nephritis Following Rituximab Therapy. [PDF]
In VivoHung SJ +6 more
europepmc +1 more source
Macrophage PABPC4‐SPP1 Axis Orchestrates Immunosuppression in Colorectal Cancer
Advanced Science, EarlyView.In the CRC microenvironment, macrophage PABPC4 binds to the 3′UTR of SPP1 mRNA to stabilize its expression, thereby sustaining M2‐like immunosuppressive macrophage polarization. Concurrently, this axis suppresses CD8+ T cell effector functions via CD44 signaling, collectively fostering an immunosuppressive niche that drives tumor progression.
Meng Wang +14 more
wiley +1 more source
Haploidentical and MHC-identical cells exhibit broadly similar immune reconstitution kinetics, with some compartment-specific differences, following hematopoietic cell transplantation in a murine model of severe combined immunodeficiency. [PDF]
Front ImmunolHidalgo I, Björklund M, Pronk CJ.
europepmc +1 more source