Results 241 to 250 of about 229,253 (309)

High-dimensionality approaches to the understanding and therapeutic manipulation of autoimmunity. [PDF]

NPJ Autoimmun
Chellamuthu VR, Zhao Y, Albani S.
europepmc   +1 more source

Modulation of the TGF‐β/Smad Signaling Pathway by a Bioactive Oxidized Polygonati Rhizoma Polysaccharide Crosslinked Chitosan Hydrogel as Therapeutic Carrier for Parkinson's Disease Treatment

Advanced Science, EarlyView.
An injectable, self‐healing COPRP hydrogel integrates structurally defined oxidized Polygonati rhizoma polysaccharide with carboxymethyl chitosan through dynamic Schiff‐base crosslinking. The bioactive matrix scavenges reactive oxygen species, suppresses neuroinflammation, protects dopaminergic neurons, and supports sustained levodopa release.
Peng Dai, Jikuang Zhao, Chang Xue, Kailei Xu, Liang Yong, Zhuangwei Zhang, Yi Huang, Jianwei Shuai, Xianzhen Chen, Sheng Nie, Junpeng Xu   +10 more
wiley   +1 more source

Functional Reconstitution of Mitochondrial Respiratory Supercomplexes. [PDF]

J Vis Exp
Padavannil A, Liu P, Letts JA.
europepmc   +1 more source

ROS/pH‐Responsive Phenylboronic Acid–Chitosan Nanoparticles Improve Silymarin‐Mediated Hepatoprotection After Hepatectomy With Gut‐Liver Axis‐Associated Responses

Advanced Science, EarlyView.
Bioactive phenylboronic acid–chitosan nanoparticles enable responsive silymarin delivery for post‐hepatectomy liver protection. The nanoplatform integrates antioxidant and antibacterial functions, improves hepatic recovery, and is associated with coordinated shifts in gut microbiota, metabolites, cytokines, and hepatic proteomic pathways, suggesting a ...
Jinjin Tong, Chaochao Luo, Zezheng Liu, Xinyan Zhang, Daixu Jia, Yang Sun, Zhaonan Zhang, Haoran Shi, Jianfang Wang, Hua Zhang   +9 more
wiley   +1 more source

Increased Output of Recent Thymic Emigrants Contributes to Reconstitution of T-Cell Pool During Recovery From COVID-19. [PDF]

Eur J Immunol
Huang X, Jokiranta ST, Nowlan K, Nguyen NA, Heikkilä N, Tola L, Kantele A, Pekkarinen PT, Hästbacka J, Vapalahti O, Heinonen S, Paajanen J, Strandin T, Kekäläinen E.   +13 more
europepmc   +1 more source

Nuclear Translocation of PFKFB3 Promotes Disuse‐Induced Muscle Atrophy via Scaffolding Nedd4‐Mediated JunB Ubiquitination

Advanced Science, EarlyView.
Disuse‐induced muscle atrophy is driven by a non‐metabolic, nuclear function of the enzyme PFKFB3. Acting as a scaffold, PFKFB3 facilitates Nedd4‐mediated ubiquitination and degradation of the anti‐atrophy transcription factor JunB. Inhibiting this novel PFKFB3–Nedd4–JunB signaling axis stabilizes JunB and alleviates muscle wasting, revealing a highly ...
Mengjun Ma, Yinliang Liu, Wangchang Wu, Biao Yang, Jiahao Zhuang, Haoye Yu, Rujia Mi, Yixuan Lu, Wen Yang, Hanting Yi, Chenglong Yuan, Yinfeng Gu, Hongyu Li   +12 more
wiley   +1 more source

Immune reconstitution and tolerance-inducing therapies as promising therapeutic approaches in multiple sclerosis. [PDF]

Neurol Sci
Maal AB, Arki MK, Nabavi SM, Rezaei-Tavirani M, Rismani E, Vosough M, Azizi G, Hossein-Khannazer N.   +7 more
europepmc   +1 more source

Rapid recovery from near-fatal immune reconstitution inflammatory syndrome and acute respiratory distress syndrome following neutropenic recovery by cytokine adsorption. [PDF]

BMC Pulm Med
Bihlmaier K, Vonbrunn L, Schmid A, Herbst L, Bujok K, Büstgens FA, Wätzig R, Waibel H, Schiffer M, Willam C.   +9 more
europepmc   +1 more source

Powder Handling and Frozen Texture of a Reconstitutable Strawberry-Oat Sorbet Premix After Sucrose Replacement. [PDF]

J Texture Stud
Dos Santos Lima C, da Silva Lannes SC.
europepmc   +1 more source

Co-receptor usage in distinct phylogenetic clusters of HIV-1 CRF01_AE is associated with differential immune reconstitution after antiretroviral therapy. [PDF]

Microbiol Spectr
Liu Y, Lu J, Qiu T, Hu Z, Li W, Li X, Du G, Zhao M, Ma H, Wei P, Yang D, Ge Y.   +11 more
europepmc   +1 more source