Results 91 to 100 of about 1,131,005 (248)

The association of painful and non-painful morbidities with frailty: a cross sectional analysis of a cohort of community dwelling older people in England

BMC Geriatrics
Introduction The association between chronic pain and frailty might indicate that pain is an independent driver of frailty but might alternatively be explained by inclusion within frailty identification tools of morbidities that commonly lead to chronic ...
W. J. Chaplin, H. R. Lewis, S. M. Shahtaheri, B. S. Millar, D. F. McWilliams, J. R. F. Gladman, D. A. Walsh   +6 more
doaj   +1 more source

New Solvent for Polyamide 66 and Its Use for Preparing a Single-Polymer Composite-Coated Fabric

International Journal of Polymer Science, 2018
Polyamides (PAs) are one of the most important engineering polymers; however, the difficulty in dissolving them hinders their applications. Formic acid (FA) is the most common solvent for PAs, but it has industrial limitations.
Mostafa Jabbari, Mikael Skrifvars, Dan Åkesson, Mohammad J. Taherzadeh   +3 more
doaj   +1 more source

A single session of exercise increases connectivity in sensorimotor-related brain networks: A resting-state fMRI study in young healthy adults

Frontiers in Human Neuroscience, 2014
Habitual long term physical activity is known to have beneficial cognitive, structural and neuro-protective brain effects, but to date there is limited knowledge on whether a single session of exercise can alter the brain’s functional connectivity, as ...
Ahmad Saeed Rajab, Ahmad Saeed Rajab, David E Crane, Laura E Middleton, Laura E Middleton, Andrew eRobertson, Michelle eHampson, Bradley J MacIntosh, Bradley J MacIntosh   +8 more
doaj   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Growth and protein content of Cupriavidus necator on organic acids derived from fermented grey starch

Applied Microbiology and Biotechnology
Grey starch (GS) is a byproduct of potato processing and is conventionally valorised as low-grade animal feed or for biogas generation. In this manuscript, we systematically investigate the mixed culture fermentation of GS to organic acids and their ...
Martin Struk, Myrsini Sakarika, Ángel Estévez, Ramon Ganigué, Korneel Rabaey   +4 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Oil recovery from fractured reservoirs using in situ and preformed particle gels in micromodel structures

Journal of Petroleum Exploration and Production Technology, 2019
Oil extraction often accompanied with relatively large amounts of water production causes several environmental and mechanical problems, particularly in oil-fractured reservoirs. One way to alleviate this problem is to use gels as a blockage agent.
Samira Heidari, Maryam Ahmadi, Feridun Esmaeilzadeh, Dariush Mowla   +3 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source