Results 81 to 90 of about 1,131,005 (248)
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Campbell Systematic ReviewsThis is the protocol for a Campbell systematic review. The objectives are as follows: (1) What kinds of mutual‐help organizations for drug use disorders have been studied with evidence available in the empirical literature?
Emily A. Hennessy +5 more
doaj +1 more source
Avian Conservation and Ecology, 2018 The Platte River Recovery Implementation Program (PRRIP) and its partners invested substantial resources in creating and managing off-channel nesting habitat for Interior Least Terns (Sternula antillarum athalassos) and Piping Plovers (Charadrius melodus)
Patrick D. Farrell +3 more
doaj +1 more source
Community Colleges: The Next Frontier of Recovery Support at Institutions of Higher Education
, 2018 In 2016, TYR could identify only six community colleges offering recovery support programs and services. Based on this finding, TYR identified a need for pilot programs to better understand programmatic models that may be effective for supporting ...
Jones, Erin K
core +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Impact of water content on minimum miscibility pressure during CO2 flooding in high water-cut reservoirs [PDF]
E3S Web of ConferencesThis study focused on the X block stratum oil, specifically addressing the application of CO2 displacement technology in enhancing oil recovery under high water content conditions.
Zhao Fajun +6 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
From acceptance to graduation: Supporting students in recovery throughout their college experience
, 2018 Students entering universities while in recovery from addiction face unique challenges, such as transitioning from a high school to a university, adapting to life after treatment, and/or transferring from a junior college or different university setting.
Singer, Leah J, Shiflet, John A
core +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source