Results 111 to 120 of about 4,894,740 (406)

Rectal Cancer [PDF]

Clinics in Colon and Rectal Surgery, 2015
James W, Fleshman, Warren E, Lichliter
  +5 more sources

Deacetylation of ACLY Mediates RNA M6A‐Modification of NOXA and Promotes Chemoresistance of Colorectal Cancer

Advanced Science, EarlyView.
This study investigates the deacetylation of ACLY at K978 acts as a novel risk in colorectal cancer chemoresistance. The deacetylation of K978 induces ACLY relocation to the nucleus and promotes its binding to RBM15, a m6A methylation modification “writer”.
Jun Wen, Mengqin Shen, Haitao Zhao, Liu Liu, Qian Hua, Xiaoping Zhao, Jianjun Liu, Haizhong Feng, Gang Huang   +8 more
wiley   +1 more source

Does ursodeoxycholic acid change the proliferation of the colorectal mucosa? A randomized, placebo-controlled study [PDF]

, 2003
Background: In animal models ursodeoxycholic acid (UDCA) showed a chemoprotective effect against colon cancer. To explain this, a reduced proliferation of the colorectal mucosal proliferation was suggested.
Diebold, J., Göke, B., Hay, U., Marsteller, I., Ochsenkühn, Thomas, Paumgartner, Gustav, Sackmann, M.   +6 more
core   +1 more source

High Expression of VSTM2L Induced Resistance to Chemoradiotherapy in Rectal Cancer through Downstream IL-4 Signaling

Journal of Immunology Research, 2021
Background. Preoperative chemoradiotherapy (pCRT) is a common and essential therapeutic strategy for patients with locally advanced rectal cancer (LARC), but poor tumor response and therapeutic resistance to chemoradiotherapy have appeared usually among ...
Hao Liu, Zhenzhan Zhang, Peilin Zhen, Meijuan Zhou   +3 more
doaj   +1 more source

Long-term Oncological and Functional Outcomes of Chemoradiotherapy Followed by Organ-Sparing Transanal Endoscopic Microsurgery for Distal Rectal Cancer: The CARTS Study

JAMA Surgery, 2019
Importance Treatment of rectal cancer is shifting toward organ preservation aiming to reduce surgery-related morbidity. Short-term outcomes of organ-preserving strategies are promising, but long-term outcomes are scarce in the literature.
Rutger C. H. Stijns, E. D. de Graaf, C. Punt, I. Nagtegaal, J. Nuyttens, E. van Meerten, P. Tanis, I. D. de Hingh, G. P. van der Schelling, Y. Acherman, J. Leijtens, A. Bremers, G. Beets, C. Hoff, C. Verhoef, C. Marijnen, J. D. de Wilt   +16 more
semanticscholar   +1 more source

Onion‐Mitochondria Inhibit Lipopolysaccharide‐Induced Acute Lung Injury by Shaping Lung Macrophage Mitochondrial Function

Advanced Science, EarlyView.
Proposed model of orally administered onion mitochondria (O‐Mit) uptake by lung macrophages and fuse with macrophage mitochondria (M‐Mit). This fusion reprograms the metabolism of dysfunctional M‐Mit in lipopolysaccharide‐induced murine acute lung injury by modulating dynamin‐related protein 1 (DRP1) phosphorylation and cardiolipin peroxidation ...
Qingbo Xu, Yun Teng, Yinan Huang, Jingyao Mu, Lucy Teng, Hongjia Qian, Qiming Huang, Minmin Liu, Yi Zou, Lifeng Zhang, Michael L Merchant, Xiang Zhang, Jun Yan, Huang‐Ge Zhang   +13 more
wiley   +1 more source

Enhanced recovery after surgery [PDF]

, 2015
Enhanced Recovery or Fast Track Recovery after Surgery protocols (ERAS) have significantly changed perioperative care following colorectal surgery and are promoted as reducing the stress response to surgery.
Horgan, Paul G., McMillan, Donald C., McSorley, Stephen T., Watt, David G.   +3 more
core   +1 more source

Laparoscopic training workshop to assess medical students’ skill acquisition and interest in surgical careers

BMC Medical Education
Background With its minimally invasive approach, laparoscopic surgery has transformed the medical landscape. As the demand for these procedures escalates, there is a pressing need for adept surgeons trained in laparoscopic techniques.
Pin-Chun Chen, Po-Wen Yang, Yi-Kai Kao, Chia-Hung Chen, Chih-Jong Tsai, Yi-Chieh Chen, Ling-Chiao Song, Kai Lung Tsai, Richard C. Wu, Chih-I Chen   +9 more
doaj   +1 more source

Tissue-associated bacterial alterations in rectal carcinoma patients revealed by 16S rRNA community profiling

Frontiers in Cellular and Infection Microbiology, 2016
Sporadic and inflammatory forms of colorectal cancer (CRC) account for more than 80% of cases. Recent publications have shown mechanistic evidence for the involvement of gut bacteria in the development of both CRC-forms.
Andrew Maltez Thomas, Andrew Maltez Thomas, Andrew Maltez Thomas, Eliane Camargo de Jesus, Eliane Camargo de Jesus, Ademar Lopes, Samuel Aguiar Junior, Maria Dirlei Begnami, Rafael Malagoli Rocha, Paola Avelar Carpinetti, Anamaria Aranha Camargo, Christian Hoffmann, Helano Carioca Freitas, Helano Carioca Freitas, Israel Tojal da Silva, Diana Noronha Nunes, Joao Carlos Setubal, Joao Carlos Setubal, Emmanuel Dias-Neto, Emmanuel Dias-Neto   +19 more
doaj   +1 more source

Vinburnine Sensitizes Radiotherapy Efficacy in Nasopharyngeal Carcinoma by Triggering Pyroptosis and Immune Responses via Activation of EDAR‐NFκB Pathway

Advanced Science, EarlyView.
This study demonstrates that vinburnine, an approved cerebrovascular drug, synergizes with radiotherapy in nasopharyngeal carcinoma (NPC) by modulating EDAR‐NFκB signaling through directly binding to EDAR, leading to triggering apoptosis/pyroptosis, and amplifying CCL5/CX3CL1‐driven T‐cell cytotoxicity.
Jing Chen, Nian Liu, Qian Tao, Jie Wu, Jinyu Huang, Can Lu, Qiuqiu Li, Liangfang Shen, Xiang Chen, Cong Peng   +9 more
wiley   +1 more source