Results 71 to 80 of about 4,845,209 (387)

Neoadjuvant Modified FOLFOX6 With or Without Radiation Versus Fluorouracil Plus Radiation for Locally Advanced Rectal Cancer: Final Results of the Chinese FOWARC Trial

Journal of Clinical Oncology, 2019
PURPOSE In the multicenter, open-label, phase III FOWARC trial, modified infusional fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) plus radiotherapy resulted in a higher pathologic complete response rate than fluorouracil plus radiotherapy in ...
Yanhong Deng, P. Chi, P. Lan, Lei Wang, Weiqing Chen, L. Cui, Daoda Chen, Jie Cao, Hongbo Wei, Xiang Peng, Zonghai Huang, Guanfu Cai, R. Zhao, Zhongcheng Huang, Lin Xu, Hongfeng Zhou, Yisheng Wei, Hao Zhang, Jian Zheng, Yan Huang, Zhi-yang Zhou, Yue Cai, L. Kang, Meijin Huang, Xiaojian Wu, J. Peng, D. Ren, Jianping Wang   +27 more
semanticscholar   +1 more source

Comprehensive profiling of lncRNAs and mRNAs enriched in small extracellular vesicles for early noninvasive detection of colorectal cancer: diagnostic panel assembly and extensive validation

Molecular Oncology, EarlyView.
Small extracellular vesicles are a promising source of diagnostic molecules. We conducted a comprehensive study, including transcriptome profiling and RT‐qPCR validation on large cohorts of samples. Diagnostic panels enabling sensitive detection of colorectal cancer and precancerous lesions were established. Some molecules were differentially expressed
Petra Vychytilova‐Faltejskova, Marketa Pavlikova, Lucie Pifkova, Robin Jugas, Tana Machackova, Lenka Radova, Milana Sachlova, Renata Bartosova, Tetiana Samoilenko, Zuzana Feckova, Jana Orlickova, Erika Slamova, Elleni Ponechal Michu, Dagmar Al Tukmachi, Michaela Ruckova, Martina Vodinska, Jan Kotoucek, Tina Catela Ivkovic, Marie Boudna, Lucia Bohovicova, Teodor Stanek, Jana Halamkova, Martin Svoboda, Vladimir Prochazka, Tomas Grolich, Zdenek Kala, Ondrej Slaby   +26 more
wiley   +1 more source

Transitional impact of short‐ and long‐term outcomes of a randomized controlled trial to evaluate laparoscopic versus open surgery for colorectal cancer from Japan Clinical Oncology Group Study JCOG0404

Annals of Gastroenterological Surgery, 2019
Background The JCOG0404 randomized controlled trial conducted to compare laparoscopic surgery (LAP) with open surgery (OP) for stage II/III colon cancer showed better short‐term outcomes and equal long‐term outcomes of LAP versus OP.
Shoichi Fujii, Tomonori Akagi, Masafumi Inomata, Hiroshi Katayama, Junki Mizusawa, Mitsuyoshi Ota, Shuji Saito, Yusuke Kinugasa, Shigeki Yamaguchi, Takeo Sato, Seigo Kitano, The Japan Clinical Oncology Group   +11 more
doaj   +1 more source

Possible role of human ribonuclease dicer in the regulation of R loops

FEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik, Paulina Krzeminska, Anna Kurzynska‐Kokorniak   +2 more
wiley   +1 more source

RhoA and Rac1 as Mechanotransduction Mediators in Colorectal Cancer

Advanced Biology, EarlyView.
Analysing RhoA and Rac1 protein levels in Colorectal cancer (CRC) samples under mechanical strain highlights their potential as diagnostic markers. Monitoring their activity could offer valuable insights into how cancer spreads, paving the way for new approaches to better understand and diagnose colorectal cancer.
Sharda Yadav, Sanjaya KC, Mark A. T. Blaskovich, Cu‐tai Lu, Alfred K Lam, Nam‐Trung Nguyen   +5 more
wiley   +1 more source

Biologically‐Inspired Melt Electrowriting for the Generation of Highly Biomimetic Functional Myocardium

Advanced Functional Materials, EarlyView.
In this work, melt electrowriting is used to fabricate a 3D printed scaffold design that generates engineered cardiac tissues with in‐plane contraction, mimicking natural myocardium. It is shown that these tissues display advanced maturation and functionality.
Olalla Iglesias‐García, María Flandes‐Iparraguirre, Pilar Montero‐Calle, Ricardo M. Rosales, Asier Ullate‐Agote, Andrea Sánchez‐Bueno, Eduardo Larequi, Ilazki Anaut‐Lusar, Nicolás Laita, Aida Oliván‐Viguera, Elena Iglesias, Gloria Abizanda, Patxi San Martín‐Úriz, Paula Aguirre‐Ruiz, Xabier L. Aranguren, Manuel García de Yébenes, Juan José Gavira, Miguel Ángel Martínez, Estefanía Peña, Manuel Doblaré, Elena M. de‐Juan‐Pardo, Esther Pueyo, Felipe Prosper, Manuel M. Mazo Vega   +23 more
wiley   +1 more source

Laparoscopy for Rectal Cancer [PDF]

Clinics in Colon and Rectal Surgery, 2017
It is evident that the use of laparoscopy in the management of rectal cancer has gained popularity in the last few years. It is still, however, not widely accepted as the standard of care. Multiple randomized trials have shown that short-term outcomes and perioperative morbidity and mortality of laparoscopic proctectomy are equivalent to open surgery ...
Chady Atallah, Jonathan E. Efron
openaire   +3 more sources

Transanal total mesorectal excision for rectal cancer has been suspended in Norway

British Journal of Surgery, 2019
Transanal total mesorectal excision (TaTME) for rectal cancer has emerged as an alternative to the traditional abdominal approach. However, concerns have been raised about local recurrence.
H. Wasmuth, A. Faerden, T. Myklebust, F. Pfeffer, F. Pfeffer, S. Norderval, R. Riis, O. C. Olsen, J. Lambrecht, H. Kørner, H. Kørner, S. Larsen, H. Forsmo, O. Baekkelund, S. Lavik, Jens-Christian Knapp, O. Sjo, G. Rashid   +17 more
semanticscholar   +1 more source

The current multidisciplinary management of rectal cancer

Annals of Gastroenterological Surgery
Multidisciplinary management of rectal cancer has rapidly evolved over the last several years. This review describes recent data surrounding total neoadjuvant therapy, organ preservation, and management of lateral pelvic lymph nodes. It then presents our
Neal Bhutiani, Oliver Peacock, Abhineet Uppal, Y. Nancy You, Brian K. Bednarski, John M. Skibber, Craig Messick, Michael G. White, George J. Chang, Tsuyoshi Konishi   +9 more
doaj   +1 more source

Transanal endoscopic cooperative surgery as a less invasive resection technique for anorectal tumors extending beyond the dentate line: Case series

Endoscopy International Open
Endoscopic submucosal dissection (ESD) and surgical local excision pose particular challenges for anorectal tumors extending beyond the dentate line, making technique selection difficult.
Kohei Shigeta, Kazunori Takada, Kinichi Hotta, Kenichiro Imai, Sayo Ito, Junya Sato, Yoichi Yamamoto, Masao Yoshida, Yuki Maeda, Noboru Kawata, Hirotoshi Ishiwatari, Hiroyuki Matsubayashi, Akio Shiomi, Hiroyasu Kagawa, Manabe Shoichi, Yusuke Yamaoka, Shunsuke Kasai, Yusuke Tanaka, Yasuyuki Hirashima, Ayako Mochizuki, Shusuke Yoshikawa, Arata Tsutsumida, Wataru Omata, Takuma Oishi, Hiroyuki Ono   +24 more
doaj   +1 more source